Detailed information    

insolico Bioinformatically predicted

Overview

Name   codY   Type   Regulator
Locus tag   SPYALAB49_RS07355 Genome accession   NC_017596
Coordinates   1443632..1444414 (-) Length   260 a.a.
NCBI ID   WP_002983278.1    Uniprot ID   A2RCV3
Organism   Streptococcus pyogenes Alab49     
Function   repress the expression of comX (predicted from homology)   
Competence regulation

Genomic Context

Location: 1438632..1449414
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  SPYALAB49_RS07325 (SPYALAB49_001500) gatA 1438844..1440310 (-) 1467 WP_003053823.1 Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatA -
  SPYALAB49_RS07330 (SPYALAB49_001501) gatC 1440310..1440612 (-) 303 WP_012560907.1 Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatC -
  SPYALAB49_RS07340 (SPYALAB49_001502) - 1440858..1441991 (-) 1134 WP_000564846.1 ISAs1-like element IS1548 family transposase -
  SPYALAB49_RS07345 (SPYALAB49_001503) - 1442169..1442393 (-) 225 WP_014635660.1 putative PEP-binding protein -
  SPYALAB49_RS07350 (SPYALAB49_001504) - 1442931..1443485 (-) 555 WP_002988559.1 cysteine hydrolase family protein -
  SPYALAB49_RS07355 (SPYALAB49_001505) codY 1443632..1444414 (-) 783 WP_002983278.1 GTP-sensing pleiotropic transcriptional regulator CodY Regulator
  SPYALAB49_RS07360 (SPYALAB49_001506) - 1444632..1445846 (-) 1215 WP_011184883.1 pyridoxal phosphate-dependent aminotransferase -
  SPYALAB49_RS07365 (SPYALAB49_001507) - 1446077..1446529 (+) 453 WP_002992571.1 universal stress protein -
  SPYALAB49_RS07370 (SPYALAB49_001508) - 1446652..1448040 (-) 1389 WP_009881044.1 Cof-type HAD-IIB family hydrolase -
  SPYALAB49_RS07375 (SPYALAB49_001509) - 1448112..1449077 (+) 966 WP_002992573.1 asparaginase -

Sequence

Protein


Download         Length: 260 a.a.        Molecular weight: 28633.76 Da        Isoelectric Point: 4.5611

>NTDB_id=40427 SPYALAB49_RS07355 WP_002983278.1 1443632..1444414(-) (codY) [Streptococcus pyogenes Alab49]
MPNLLEKTRKITSILQRSVDSLETELPYNTMASRLADIIDCNACIINGGGTLLGYAMKYKTNTDRVEEFFEAKQFPDTYV
KAASRVYDTEANLSVENELTIFPVESKDTYPGGLTTIAPIYGGGMRLGSLIIWRNDNEFSDDDLILVEISSTVVGIQLLN
LQTENLEDTIRKQTAVNMAINTLSYSEMKAVAAILGELDGNEGRLTASVIADRIGITRSVIVNALRKLESAGIIESRSLG
MKGTYLKVINEGIFAKLKEF

Nucleotide


Download         Length: 783 bp        

>NTDB_id=40427 SPYALAB49_RS07355 WP_002983278.1 1443632..1444414(-) (codY) [Streptococcus pyogenes Alab49]
ATGCCTAACTTATTAGAAAAAACTCGTAAAATCACATCTATTTTGCAGCGTTCCGTAGATAGCCTAGAAACAGAATTACC
GTATAACACAATGGCATCTCGCCTAGCAGATATCATTGACTGCAATGCTTGTATTATCAATGGCGGCGGCACACTGCTTG
GTTATGCCATGAAATATAAAACTAACACTGATCGTGTTGAGGAATTTTTTGAAGCTAAACAATTTCCAGATACTTATGTA
AAGGCTGCTAGCCGAGTTTACGATACAGAAGCTAACCTTTCTGTCGAAAATGAATTGACTATATTCCCTGTTGAGTCTAA
AGACACTTATCCAGGAGGTCTAACGACTATTGCGCCGATTTATGGTGGAGGGATGCGCCTTGGATCACTCATTATCTGGC
GTAATGACAATGAGTTTAGTGATGATGATTTGATTTTGGTTGAGATCTCAAGTACTGTTGTGGGGATTCAACTATTAAAT
CTTCAGACAGAAAACTTAGAAGACACCATCCGTAAACAAACAGCGGTCAACATGGCAATTAATACGCTTTCTTATTCAGA
AATGAAAGCTGTTGCAGCAATTCTTGGAGAGTTAGATGGTAACGAAGGACGATTGACAGCTTCTGTTATTGCTGATCGTA
TTGGTATTACCCGTTCTGTTATTGTCAATGCTCTGCGTAAATTAGAAAGTGCAGGGATTATTGAAAGTCGTTCTCTTGGT
ATGAAAGGGACATACCTCAAAGTTATCAACGAAGGTATTTTTGCTAAATTAAAAGAATTTTAA

Domains

Predicted by InterProScan.

CodY helix-turn-helix domain (HTH_CodY)

(202-260)

CodY GAF-like domain (CodY)

(3-182)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A2RCV3

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  codY Lactococcus lactis subsp. lactis strain DGCC12653

66.148

98.846

0.654
  codY Bacillus subtilis subsp. subtilis str. 168

51.373

98.077

0.504

Multiple sequence alignment