Detailed information
Bioinformatically predicted
Overview
| Name | ciaH | Type | Regulator |
| Locus tag | GL183_RS07535 | Genome accession | NZ_CP046355 |
| Coordinates | 1451269..1452603 (-) | Length | 444 a.a. |
| NCBI ID | WP_000491790.1 | Uniprot ID | Q7B3G0 |
| Organism | Streptococcus pneumoniae strain 475 | ||
| Function | repress competence development; post-transcriptional repression of CSP production (predicted from homology) Competence regulation |
||
Related MGE
Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.
Gene-MGE association summary
| MGE type | MGE coordinates | Gene coordinates | Relative position | Distance (bp) |
|---|---|---|---|---|
| Prophage | 1433299..1508437 | 1451269..1452603 | within | 0 |
| IS/Tn | 1453485..1454741 | 1451269..1452603 | flank | 882 |
Gene organization within MGE regions
Location: 1433299..1508437
| Locus tag | Gene name | Coordinates (strand) | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| GL183_RS07455 (GL183_07515) | - | 1433299..1434033 (-) | 735 | WP_000140941.1 | amino acid ABC transporter ATP-binding protein | - |
| GL183_RS07460 (GL183_07520) | - | 1434033..1434716 (-) | 684 | WP_001011633.1 | amino acid ABC transporter permease | - |
| GL183_RS07465 (GL183_07525) | - | 1434906..1435136 (+) | 231 | WP_000443573.1 | YkuJ family protein | - |
| GL183_RS07470 (GL183_07530) | clpE | 1435365..1437623 (+) | 2259 | WP_000882517.1 | ATP-dependent Clp protease ATP-binding subunit | Regulator |
| GL183_RS07475 (GL183_07535) | - | 1437830..1438676 (-) | 847 | Protein_1438 | IS630 family transposase | - |
| GL183_RS07480 (GL183_07540) | - | 1438753..1439209 (+) | 457 | Protein_1439 | NUDIX hydrolase | - |
| GL183_RS07485 (GL183_07545) | - | 1439374..1439673 (+) | 300 | WP_000767193.1 | DUF1827 family protein | - |
| GL183_RS07490 (GL183_07550) | tnpB | 1439934..1440257 (+) | 324 | WP_000973421.1 | IS66 family insertion sequence element accessory protein TnpB | - |
| GL183_RS07495 (GL183_07560) | ezrA | 1440986..1442713 (-) | 1728 | WP_000064817.1 | septation ring formation regulator EzrA | - |
| GL183_RS07500 (GL183_07565) | gyrB | 1442795..1444741 (-) | 1947 | WP_000134047.1 | DNA topoisomerase (ATP-hydrolyzing) subunit B | - |
| GL183_RS07505 (GL183_07570) | - | 1444756..1445319 (-) | 564 | WP_001812999.1 | HAD family hydrolase | - |
| GL183_RS07510 (GL183_07575) | - | 1445404..1445958 (-) | 555 | WP_000241398.1 | DJ-1 family glyoxalase III | - |
| GL183_RS07515 (GL183_07580) | - | 1445969..1447192 (-) | 1224 | WP_000830659.1 | FtsW/RodA/SpoVE family cell cycle protein | - |
| GL183_RS07520 (GL183_07585) | - | 1447229..1449679 (-) | 2451 | WP_000848695.1 | bifunctional DnaQ family exonuclease/ATP-dependent helicase | - |
| GL183_RS07525 (GL183_07590) | - | 1449879..1450808 (-) | 930 | WP_000411854.1 | peptidase U32 family protein | - |
| GL183_RS07530 (GL183_07595) | - | 1450948..1451235 (+) | 288 | WP_001145225.1 | DUF3270 domain-containing protein | - |
| GL183_RS07535 (GL183_07600) | ciaH | 1451269..1452603 (-) | 1335 | WP_000491790.1 | two-component system sensor histidine kinase CiaH | Regulator |
| GL183_RS07540 (GL183_07605) | ciaR | 1452593..1453267 (-) | 675 | WP_000590640.1 | two-component system response regulator CiaR | Regulator |
| GL183_RS07545 (GL183_07610) | - | 1453485..1454741 (+) | 1257 | WP_197097732.1 | ISL3-like element IS1167A family transposase | - |
| GL183_RS07550 (GL183_07615) | - | 1454800..1457346 (-) | 2547 | WP_001149118.1 | M1 family metallopeptidase | - |
| GL183_RS07555 (GL183_07620) | - | 1457469..1457909 (-) | 441 | WP_024477922.1 | ASCH domain-containing protein | - |
| GL183_RS07560 (GL183_07625) | - | 1457884..1458753 (-) | 870 | WP_001245817.1 | putative PEP-binding protein | - |
| GL183_RS07565 (GL183_07630) | - | 1458795..1459523 (-) | 729 | WP_000418692.1 | GNAT family N-acetyltransferase | - |
| GL183_RS07570 (GL183_07635) | - | 1459531..1460010 (-) | 480 | WP_024477923.1 | NUDIX hydrolase | - |
| GL183_RS07575 (GL183_07640) | - | 1460021..1460719 (-) | 699 | WP_024477924.1 | 3-oxoacyl-ACP reductase | - |
| GL183_RS07580 (GL183_07645) | - | 1460712..1460948 (-) | 237 | WP_000141921.1 | DUF2829 domain-containing protein | - |
| GL183_RS07585 (GL183_07650) | - | 1461044..1461970 (-) | 927 | WP_024477925.1 | aldo/keto reductase family oxidoreductase | - |
| GL183_RS07590 (GL183_07655) | - | 1462045..1462860 (-) | 816 | WP_024477926.1 | membrane protein | - |
| GL183_RS07595 (GL183_07660) | - | 1462864..1463184 (-) | 321 | WP_000665420.1 | PadR family transcriptional regulator | - |
| GL183_RS11425 | - | 1463274..1463645 (-) | 372 | WP_061454783.1 | hypothetical protein | - |
| GL183_RS07610 (GL183_07670) | metG | 1463695..1465692 (-) | 1998 | WP_024478005.1 | methionine--tRNA ligase | - |
| GL183_RS07615 (GL183_07675) | - | 1465816..1467075 (-) | 1260 | WP_001180430.1 | ABC transporter permease | - |
| GL183_RS07620 (GL183_07680) | - | 1467077..1467778 (-) | 702 | WP_000811482.1 | ABC transporter ATP-binding protein | - |
| GL183_RS07625 (GL183_07685) | - | 1467762..1468961 (-) | 1200 | WP_000728634.1 | efflux RND transporter periplasmic adaptor subunit | - |
| GL183_RS07630 (GL183_07690) | gor | 1469226..1470572 (+) | 1347 | WP_001209571.1 | glutathione-disulfide reductase | - |
| GL183_RS07635 (GL183_07695) | - | 1470738..1471238 (-) | 501 | WP_000727307.1 | hypothetical protein | - |
| GL183_RS07640 (GL183_07700) | - | 1471235..1471858 (-) | 624 | WP_000151029.1 | ATP-binding cassette domain-containing protein | - |
| GL183_RS07645 (GL183_07705) | - | 1471855..1473837 (-) | 1983 | WP_000768912.1 | hypothetical protein | - |
| GL183_RS07650 (GL183_07710) | - | 1473903..1474241 (-) | 339 | WP_000746105.1 | hypothetical protein | - |
| GL183_RS07655 (GL183_07715) | - | 1474667..1475203 (+) | 537 | WP_000709036.1 | biotin transporter BioY | - |
| GL183_RS11430 | - | 1475265..1475411 (+) | 147 | WP_001809980.1 | hypothetical protein | - |
| GL183_RS07665 (GL183_07725) | - | 1475408..1475623 (-) | 216 | WP_000807422.1 | YdbC family protein | - |
| GL183_RS07670 (GL183_07730) | - | 1475721..1476041 (+) | 321 | WP_001216099.1 | hypothetical protein | - |
| GL183_RS07675 (GL183_07735) | - | 1476072..1476410 (-) | 339 | WP_001196049.1 | ATP cone domain-containing protein | - |
| GL183_RS07680 (GL183_07740) | trmD | 1476422..1477141 (-) | 720 | WP_000686921.1 | tRNA (guanosine(37)-N1)-methyltransferase TrmD | - |
| GL183_RS07685 (GL183_07745) | rimM | 1477131..1477649 (-) | 519 | WP_001105899.1 | ribosome maturation factor RimM | - |
| GL183_RS07690 (GL183_07750) | - | 1477719..1478468 (-) | 750 | WP_197097733.1 | alpha/beta hydrolase | - |
| GL183_RS11435 | - | 1478572..1478895 (-) | 324 | Protein_1481 | MazG nucleotide pyrophosphohydrolase domain-containing protein | - |
| GL183_RS07700 (GL183_07760) | kphA | 1479044..1479283 (-) | 240 | WP_000379621.1 | RNA-binding protein KphA | - |
| GL183_RS07705 (GL183_07765) | rpsP | 1479303..1479575 (-) | 273 | WP_000268761.1 | 30S ribosomal protein S16 | - |
| GL183_RS07710 (GL183_07770) | - | 1479745..1479954 (+) | 210 | WP_000953865.1 | hypothetical protein | - |
| GL183_RS07715 (GL183_07775) | - | 1480433..1480654 (+) | 222 | WP_000011699.1 | hypothetical protein | - |
| GL183_RS07720 (GL183_07780) | - | 1480738..1481541 (+) | 804 | WP_000731918.1 | peptidylprolyl isomerase | - |
| GL183_RS07725 (GL183_07785) | - | 1481708..1482964 (+) | 1257 | WP_050229463.1 | ISL3 family transposase | - |
| GL183_RS07730 (GL183_07790) | - | 1483019..1484560 (-) | 1542 | WP_000025400.1 | ABC-F family ATP-binding cassette domain-containing protein | - |
| GL183_RS07735 (GL183_07795) | - | 1484562..1485044 (-) | 483 | WP_000976708.1 | VanZ family protein | - |
| GL183_RS07740 (GL183_07800) | rlmN | 1485044..1485946 (-) | 903 | WP_000804656.1 | 23S rRNA (adenine(2503)-C(2))-methyltransferase RlmN | - |
| GL183_RS07745 (GL183_07805) | - | 1485967..1486497 (-) | 531 | WP_001224351.1 | YutD family protein | - |
| GL183_RS07750 (GL183_07810) | sodA | 1486655..1487260 (-) | 606 | WP_000974746.1 | superoxide dismutase SodA | - |
| GL183_RS07755 (GL183_07815) | holA | 1487401..1488438 (-) | 1038 | WP_000879650.1 | DNA polymerase III subunit delta | - |
| GL183_RS07760 (GL183_07820) | - | 1488472..1489407 (-) | 936 | WP_024477895.1 | dihydroorotate oxidase | - |
| GL183_RS07765 (GL183_07825) | metK | 1489960..1491150 (-) | 1191 | WP_000003936.1 | methionine adenosyltransferase | - |
| GL183_RS07770 (GL183_07830) | - | 1491365..1492708 (-) | 1344 | WP_000011015.1 | DEAD/DEAH box helicase | - |
| GL183_RS07775 (GL183_07835) | - | 1492848..1493663 (-) | 816 | WP_000670830.1 | endonuclease/exonuclease/phosphatase family protein | - |
| GL183_RS07780 (GL183_07840) | - | 1493715..1495895 (-) | 2181 | WP_000974062.1 | PTS transporter subunit IIBC | - |
| GL183_RS07785 (GL183_07845) | - | 1496292..1497245 (+) | 954 | WP_001155339.1 | IS30-like element ISSpn8 family transposase | - |
| GL183_RS07790 (GL183_07850) | ftsX | 1497427..1498353 (-) | 927 | WP_024477896.1 | permease-like cell division protein FtsX | - |
| GL183_RS07795 (GL183_07855) | ftsE | 1498346..1499038 (-) | 693 | WP_000022264.1 | cell division ATP-binding protein FtsE | - |
| GL183_RS07805 (GL183_07865) | - | 1500259..1500915 (-) | 657 | WP_000268677.1 | CBS domain-containing protein | - |
| GL183_RS07810 (GL183_07870) | - | 1501329..1502039 (-) | 711 | WP_000062219.1 | ABC transporter ATP-binding protein | - |
| GL183_RS07815 (GL183_07875) | - | 1502039..1502803 (-) | 765 | WP_001186003.1 | ABC transporter ATP-binding protein | - |
| GL183_RS07820 (GL183_07880) | - | 1502803..1503759 (-) | 957 | WP_000662292.1 | branched-chain amino acid ABC transporter permease | - |
| GL183_RS07825 (GL183_07885) | - | 1503763..1504632 (-) | 870 | WP_000941421.1 | branched-chain amino acid ABC transporter permease | - |
| GL183_RS07830 (GL183_07890) | - | 1504900..1506060 (-) | 1161 | WP_000726146.1 | ABC transporter substrate-binding protein | - |
| GL183_RS07835 (GL183_07895) | - | 1506161..1506409 (-) | 249 | WP_000462126.1 | YlbG family protein | - |
| GL183_RS07840 (GL183_07900) | clpP | 1506488..1507078 (-) | 591 | WP_000613477.1 | ATP-dependent Clp protease proteolytic subunit ClpP | Regulator |
| GL183_RS07845 (GL183_07905) | upp | 1507252..1507881 (-) | 630 | WP_001812010.1 | uracil phosphoribosyltransferase | - |
| GL183_RS07850 (GL183_07910) | - | 1507970..1508437 (-) | 468 | WP_000136976.1 | cytidine/deoxycytidylate deaminase family protein | - |
Sequence
Protein
Download Length: 444 a.a. Molecular weight: 50673.39 Da Isoelectric Point: 9.1661
>NTDB_id=403053 GL183_RS07535 WP_000491790.1 1451269..1452603(-) (ciaH) [Streptococcus pneumoniae strain 475]
MFSKLKKTWYADDFSYFIRNFGVFTLIFSTMTLIILQVMHSSLYTSVDDKLHGLSENPQAVIQLAINRATEEIKDLENAR
ADASKVEIKPNVSSNTEVILFDKDFTQLLSGNRFLGLDKIKLEKKELGHIYQIQVFNSYGQEEIYRVILMETNISSVSTN
IKYAAVLINTSQLEQASQKHEQLIVVVMASFWILSLLASLYLARVSVRPLLESMQKQQSFVENASHELRTPLAVLQNRLE
TLFRKPEATIMDVSESIASSLEEVRNMRFLTTSLLNLARRDDGIKPELAEVPTSFFNTTFTNYEMIASENNRVFRFENRI
HRTIVTDQLLLKQLMTILFDNAVKYTEEDGEIDFLISATDRNLYLLVSDNGIGISTEDKKKIFDRFYRVDKARTRQKGGF
GLGLSLAKQIVDALKGTVTVKDNKPKGTIFEVKIAIQTPSKKKK
MFSKLKKTWYADDFSYFIRNFGVFTLIFSTMTLIILQVMHSSLYTSVDDKLHGLSENPQAVIQLAINRATEEIKDLENAR
ADASKVEIKPNVSSNTEVILFDKDFTQLLSGNRFLGLDKIKLEKKELGHIYQIQVFNSYGQEEIYRVILMETNISSVSTN
IKYAAVLINTSQLEQASQKHEQLIVVVMASFWILSLLASLYLARVSVRPLLESMQKQQSFVENASHELRTPLAVLQNRLE
TLFRKPEATIMDVSESIASSLEEVRNMRFLTTSLLNLARRDDGIKPELAEVPTSFFNTTFTNYEMIASENNRVFRFENRI
HRTIVTDQLLLKQLMTILFDNAVKYTEEDGEIDFLISATDRNLYLLVSDNGIGISTEDKKKIFDRFYRVDKARTRQKGGF
GLGLSLAKQIVDALKGTVTVKDNKPKGTIFEVKIAIQTPSKKKK
Nucleotide
Download Length: 1335 bp
>NTDB_id=403053 GL183_RS07535 WP_000491790.1 1451269..1452603(-) (ciaH) [Streptococcus pneumoniae strain 475]
ATGTTCAGTAAACTTAAAAAAACATGGTATGCGGATGACTTTAGTTATTTTATCCGCAACTTCGGTGTCTTCACCCTGAT
TTTTTCTACAATGACTCTGATTATTTTACAAGTCATGCATTCGAGTCTTTATACTTCGGTGGACGATAAGCTTCATGGAC
TGAGTGAAAATCCTCAAGCAGTTATTCAGCTGGCTATAAATAGGGCAACAGAAGAGATTAAAGATTTAGAAAATGCTAGG
GCGGACGCTAGTAAAGTAGAAATAAAACCTAATGTCAGTTCCAATACGGAAGTCATTCTCTTTGATAAAGACTTTACTCA
ACTTCTTTCTGGAAATCGATTTTTGGGCTTGGATAAGATTAAGTTAGAAAAGAAAGAACTAGGACATATCTACCAGATTC
AGGTTTTTAATAGCTATGGGCAGGAAGAAATCTATCGTGTGATTTTGATGGAGACCAATATTAGTTCGGTTTCAACCAAT
ATCAAGTATGCTGCTGTCTTGATTAATACCAGTCAGTTGGAGCAGGCTAGTCAAAAGCATGAGCAATTGATTGTGGTCGT
GATGGCTAGTTTCTGGATTTTGTCTTTACTTGCCAGTCTCTATCTAGCTAGGGTCAGTGTTAGGCCCCTGCTTGAGAGTA
TGCAGAAGCAACAGTCTTTTGTGGAAAATGCCAGTCATGAGTTACGAACTCCACTCGCAGTTTTGCAAAATCGCTTAGAG
ACCCTTTTTCGTAAGCCAGAAGCTACCATTATGGATGTGAGCGAAAGCATTGCATCGAGTTTGGAAGAAGTCCGAAATAT
GCGTTTTTTAACGACAAGCTTGCTGAACTTAGCTCGGAGAGATGATGGGATTAAGCCGGAGCTTGCAGAAGTTCCAACTA
GCTTTTTTAATACAACTTTCACAAACTATGAGATGATTGCTTCGGAAAATAATCGTGTCTTCCGTTTTGAAAATCGTATC
CATCGAACAATTGTCACAGATCAGCTTCTTCTGAAACAACTGATGACCATTCTTTTCGATAATGCCGTCAAGTATACTGA
GGAGGATGGTGAAATTGATTTTCTTATCTCGGCGACCGATCGCAATCTTTATTTACTTGTTTCTGATAATGGAATCGGTA
TTTCGACAGAAGATAAAAAGAAAATTTTTGACCGTTTTTATCGAGTAGACAAAGCTAGAACCCGGCAAAAAGGTGGTTTT
GGTTTAGGATTATCCCTAGCCAAGCAAATTGTAGATGCTCTAAAAGGAACTGTTACTGTCAAAGATAATAAACCCAAGGG
AACAATCTTTGAAGTGAAGATTGCCATTCAGACACCATCTAAAAAGAAAAAATAA
ATGTTCAGTAAACTTAAAAAAACATGGTATGCGGATGACTTTAGTTATTTTATCCGCAACTTCGGTGTCTTCACCCTGAT
TTTTTCTACAATGACTCTGATTATTTTACAAGTCATGCATTCGAGTCTTTATACTTCGGTGGACGATAAGCTTCATGGAC
TGAGTGAAAATCCTCAAGCAGTTATTCAGCTGGCTATAAATAGGGCAACAGAAGAGATTAAAGATTTAGAAAATGCTAGG
GCGGACGCTAGTAAAGTAGAAATAAAACCTAATGTCAGTTCCAATACGGAAGTCATTCTCTTTGATAAAGACTTTACTCA
ACTTCTTTCTGGAAATCGATTTTTGGGCTTGGATAAGATTAAGTTAGAAAAGAAAGAACTAGGACATATCTACCAGATTC
AGGTTTTTAATAGCTATGGGCAGGAAGAAATCTATCGTGTGATTTTGATGGAGACCAATATTAGTTCGGTTTCAACCAAT
ATCAAGTATGCTGCTGTCTTGATTAATACCAGTCAGTTGGAGCAGGCTAGTCAAAAGCATGAGCAATTGATTGTGGTCGT
GATGGCTAGTTTCTGGATTTTGTCTTTACTTGCCAGTCTCTATCTAGCTAGGGTCAGTGTTAGGCCCCTGCTTGAGAGTA
TGCAGAAGCAACAGTCTTTTGTGGAAAATGCCAGTCATGAGTTACGAACTCCACTCGCAGTTTTGCAAAATCGCTTAGAG
ACCCTTTTTCGTAAGCCAGAAGCTACCATTATGGATGTGAGCGAAAGCATTGCATCGAGTTTGGAAGAAGTCCGAAATAT
GCGTTTTTTAACGACAAGCTTGCTGAACTTAGCTCGGAGAGATGATGGGATTAAGCCGGAGCTTGCAGAAGTTCCAACTA
GCTTTTTTAATACAACTTTCACAAACTATGAGATGATTGCTTCGGAAAATAATCGTGTCTTCCGTTTTGAAAATCGTATC
CATCGAACAATTGTCACAGATCAGCTTCTTCTGAAACAACTGATGACCATTCTTTTCGATAATGCCGTCAAGTATACTGA
GGAGGATGGTGAAATTGATTTTCTTATCTCGGCGACCGATCGCAATCTTTATTTACTTGTTTCTGATAATGGAATCGGTA
TTTCGACAGAAGATAAAAAGAAAATTTTTGACCGTTTTTATCGAGTAGACAAAGCTAGAACCCGGCAAAAAGGTGGTTTT
GGTTTAGGATTATCCCTAGCCAAGCAAATTGTAGATGCTCTAAAAGGAACTGTTACTGTCAAAGATAATAAACCCAAGGG
AACAATCTTTGAAGTGAAGATTGCCATTCAGACACCATCTAAAAAGAAAAAATAA
Similar proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| ciaH | Streptococcus pneumoniae Rx1 |
100 |
100 |
1 |
| ciaH | Streptococcus pneumoniae D39 |
100 |
100 |
1 |
| ciaH | Streptococcus pneumoniae R6 |
100 |
100 |
1 |
| ciaH | Streptococcus pneumoniae TIGR4 |
100 |
100 |
1 |
| ciaH | Streptococcus mutans UA159 |
55.632 |
97.973 |
0.545 |