Detailed information NTG0402979

Bioinformatically predicted

Overview

• Name: comE/blpR
• Type: Regulator
• Locus tag: GLO74_RS08455
• Genome accession: NZ_CP046354
• Coordinates: 1650916..1651653 (-)
• Length: 245 a.a.
• NCBI ID: WP_001219120.1
• Uniprot ID: Q9S1I6
• Organism: Streptococcus pneumoniae strain 310
• Function: activate transcription of early competence genes; regulation of comX expression (predicted from homology) Competence regulation

Genomic Context

Location: 1645916..1656653

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
GLO74_RS08435 (GLO74_08555)	comA/nlmT	1646291..1647934 (+)	1644	WP_078133412.1	peptide cleavage/export ABC transporter	Regulator
GLO74_RS08440 (GLO74_08560)	-	1647945..1649306 (+)	1362	WP_197097175.1	bacteriocin secretion accessory protein	-
GLO74_RS08445 (GLO74_08565)	blpC	1649363..1649491 (+)	129	WP_000358815.1	quorum-sensing system pheromone BlpC	-
GLO74_RS08450 (GLO74_08570)	-	1649562..1650902 (-)	1341	WP_001017642.1	sensor histidine kinase	-
GLO74_RS08455 (GLO74_08575)	comE/blpR	1650916..1651653 (-)	738	WP_001219120.1	response regulator transcription factor	Regulator
GLO74_RS08460 (GLO74_08580)	-	1651658..1651996 (-)	339	WP_000876675.1	LytTR family DNA-binding domain-containing protein	-
GLO74_RS08465 (GLO74_08585)	-	1652272..1652601 (+)	330	WP_000132572.1	hypothetical protein	-
GLO74_RS08470 (GLO74_08590)	-	1652769..1653818 (-)	1050	WP_000653771.1	ABC transporter permease	-
GLO74_RS08475 (GLO74_08595)	pptA	1653815..1654546 (-)	732	WP_000889921.1	ABC transporter ATP-binding protein	Regulator
GLO74_RS08480 (GLO74_08600)	-	1654614..1655024 (+)	411	WP_001278301.1	HIT family protein	-
GLO74_RS08485 (GLO74_08605)	-	1655034..1655321 (+)	288	WP_000777753.1	hypothetical protein	-
GLO74_RS08490 (GLO74_08610)	-	1655483..1655677 (+)	195	WP_001808905.1	hypothetical protein	-

Sequence

Protein

• Length: 245 a.a.
• Molecular weight: 28754.98 Da
• Isoelectric Point: 6.5884

>NTDB_id=402979 GLO74_RS08455 WP_001219120.1 1650916..1651653(-) (comE/blpR) [Streptococcus pneumoniae strain 310]
MRIFVLEDDFSQQTRIETTIEKLLKAHHIIPSSFEVFGKPDQLLAEVHEKGAHQLFFLDIEIRNEEMKGLEVARKIRDRD
PYALIVFVTTHSEFMPLSFRYQVSALDYIDKALSAEEFESRIETALLYANSQDSKSLAEDCFYFKSKFAQFQYPFKEVYY
LETSPRAHRVILYTKTDRLEFTASLEEVFKQEPRLLQCHRSFLINPANVVHLDKKEKLLFFPNGGSCLIARYKVREVSEA
INKLH

Nucleotide

• Length: 738 bp

>NTDB_id=402979 GLO74_RS08455 WP_001219120.1 1650916..1651653(-) (comE/blpR) [Streptococcus pneumoniae strain 310]
ATGAGAATATTTGTTTTAGAGGATGATTTTTCCCAACAGACTAGAATTGAAACGACGATTGAGAAACTTTTGAAAGCACA
TCATATCATTCCTAGCTCTTTTGAGGTATTTGGCAAGCCGGACCAACTGCTGGCTGAAGTGCATGAGAAGGGGGCCCATC
AGCTATTCTTTTTGGATATTGAGATTCGAAATGAAGAGATGAAGGGACTGGAAGTGGCTAGAAAGATTCGGGATCGGGAT
CCTTATGCCCTGATTGTCTTTGTGACGACTCACTCGGAGTTTATGCCCCTGTCTTTTCGCTACCAAGTGTCTGCTTTGGA
CTACATTGATAAGGCCTTGTCAGCAGAGGAGTTTGAATCTCGGATCGAGACAGCCCTCCTCTATGCCAATAGTCAAGATA
GTAAAAGTCTGGCGGAAGATTGCTTTTACTTTAAATCAAAATTTGCCCAATTTCAGTATCCTTTTAAAGAGGTTTACTAT
CTCGAAACGTCGCCCAGAGCCCATCGTGTTATTCTCTATACCAAGACAGACAGGCTGGAATTTACAGCGAGTTTAGAGGA
GGTTTTCAAGCAGGAGCCCCGTCTCTTGCAGTGCCACCGCTCTTTTCTCATCAATCCTGCAAATGTGGTGCATTTGGATA
AGAAAGAAAAACTGCTTTTCTTTCCCAATGGTGGAAGTTGTCTAATCGCCCGTTATAAGGTCAGGGAAGTGTCTGAGGCC
ATCAATAAATTACACTGA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (3-122)

• LytTr DNA-binding domain (LytTR) (151-241)

3D structure

• AlphaFold DB: Q9S1I6

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE/blpR	Streptococcus mutans UA159	54.321	99.184	0.539
comE/comE1	Streptococcus equinus JB1	43.46	96.735	0.42
comE/comE2	Streptococcus equinus JB1	38.017	98.776	0.376
comE	Streptococcus infantis strain Atu-4	35.887	100	0.363