Detailed information NTG0402918

Bioinformatically predicted

Overview

• Name: comD/comD2
• Type: Regulator
• Locus tag: GLO74_RS00025
• Genome accession: NZ_CP046354
• Coordinates: 1531..2856 (+)
• Length: 441 a.a.
• NCBI ID: WP_024477997.1
• Uniprot ID: -
• Organism: Streptococcus pneumoniae strain 310
• Function: phosphorylation of ComE (predicted from homology) Competence regulation

Genomic Context

Location: 1..7856

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
GLO74_RS00010 (GLO74_00010)	rlmH	624..1103 (+)	480	WP_000695929.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
GLO74_RS00020 (GLO74_00020)	comC/comC2	1385..1510 (+)	126	WP_000799694.1	competence-stimulating peptide ComC	Regulator
GLO74_RS00025 (GLO74_00025)	comD/comD2	1531..2856 (+)	1326	WP_024477997.1	competence system sensor histidine kinase ComD	Regulator
GLO74_RS00030 (GLO74_00030)	comE	2853..3605 (+)	753	WP_000866065.1	competence system response regulator transcription factor ComE	Regulator
GLO74_RS00045 (GLO74_00045)	-	3848..4390 (-)	543	WP_001158269.1	TetR/AcrR family transcriptional regulator	-
GLO74_RS11365	-	4569..6172 (+)	1604	Protein_6	YhgE/Pip family protein	-

Sequence

Protein

• Length: 441 a.a.
• Molecular weight: 51489.09 Da
• Isoelectric Point: 7.5816

>NTDB_id=402918 GLO74_RS00025 WP_024477997.1 1531..2856(+) (comD/comD2) [Streptococcus pneumoniae strain 310]
MDLLGFGTVIVHFLIISHSYRLICKGRINRKELYIFGAYTLLTEIVLEFSFYLLYLDKIGIERFLFPLGLYSYFRWMKQY
ERDRGLFLSLLLSLLYESTHNFLSVTFSSITGDNFVLQYHFPFFFVVTVLTYFVTLKIIYYFHLELAYFDKDYFYPFLKK
VFFALLLLHIVSFVSDMVSTIKHLNSFGSILSSIVFISLLLTFFAMNSHKVQMEKEIALKQKKFEQKHLQNYTDEIVGLY
NEIRGFRHDYAGMLVSMQMAIDSGNLQEIDRIYNEVLVKANHKLRSDKYTYFDLNNIEDSALRSLVAQSIVYARNNGVEF
TLEVKDTITKLPIELLDLVRIMSVLLNNAVEGSADSYKKQMEVAVIKMETETVMVIQNSCKMTMTPSGDLFALGFSTKGR
NRGVGLNNVKELLDKYNNIILETEMEGSTFRQIIRFKREFE

Nucleotide

• Length: 1326 bp

>NTDB_id=402918 GLO74_RS00025 WP_024477997.1 1531..2856(+) (comD/comD2) [Streptococcus pneumoniae strain 310]
ATGGATTTACTTGGATTTGGGACAGTTATTGTTCATTTTTTAATTATTAGTCACAGTTACCGTTTAATTTGTAAAGGTCG
AATAAATAGAAAAGAATTATACATTTTTGGTGCTTATACATTACTAACTGAAATAGTACTTGAATTTTCCTTTTATCTTC
TATATTTAGATAAAATAGGGATTGAAAGATTTTTATTTCCTTTGGGCTTATATTCCTATTTTCGATGGATGAAACAGTAT
GAGAGGGATAGAGGACTATTCCTAAGTTTACTACTATCTCTTTTATATGAGAGCACTCATAACTTTCTGTCCGTAACTTT
CTCCTCTATAACAGGAGATAATTTTGTTTTACAATATCATTTCCCATTCTTTTTCGTTGTGACGGTGTTAACCTATTTTG
TTACATTAAAAATCATTTATTATTTCCATTTGGAACTAGCCTATTTTGACAAGGACTACTTTTATCCTTTCTTGAAAAAA
GTATTTTTTGCTTTACTATTGCTACATATTGTATCTTTCGTTTCAGATATGGTAAGTACGATTAAACATTTGAATAGTTT
TGGAAGTATTTTGTCATCTATTGTCTTTATCTCTCTCCTTTTGACCTTCTTTGCAATGAATTCTCATAAAGTTCAAATGG
AGAAAGAGATTGCTTTGAAGCAGAAGAAATTTGAACAGAAACATTTACAGAATTACACAGATGAAATTGTTGGTCTGTAT
AATGAAATCCGTGGTTTTCGACATGATTATGCTGGAATGCTTGTCAGCATGCAGATGGCAATTGACAGTGGTAATTTACA
GGAAATTGACAGAATTTACAATGAAGTTTTAGTCAAAGCAAATCATAAATTGCGTTCAGATAAGTACACTTACTTTGATT
TGAACAACATAGAAGACTCAGCTTTACGAAGTTTGGTTGCTCAGTCAATTGTCTATGCTCGAAATAATGGTGTAGAGTTT
ACACTGGAAGTAAAAGATACGATTACCAAGCTTCCAATTGAACTATTGGATTTGGTTCGTATCATGAGCGTTTTATTGAA
TAATGCTGTCGAAGGATCGGCTGATAGCTATAAAAAGCAGATGGAAGTAGCAGTTATTAAGATGGAAACTGAAACAGTTA
TGGTGATTCAGAATTCATGTAAAATGACGATGACTCCTTCAGGAGATCTATTTGCCTTAGGATTCTCCACTAAGGGAAGA
AATCGCGGAGTCGGATTAAATAATGTGAAAGAACTACTAGATAAGTACAACAATATTATTTTAGAAACAGAGATGGAAGG
CAGTACATTTAGACAAATCATTAGATTTAAGAGGGAATTTGAATGA

Domains

Predicted by InterproScan.

• GHKL domain (HATPase_c_5) (334-434)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comD/comD2	Streptococcus pneumoniae TIGR4	99.093	100	0.991
comD/comD1	Streptococcus pneumoniae Rx1	96.372	100	0.964
comD/comD1	Streptococcus pneumoniae D39	96.372	100	0.964
comD/comD1	Streptococcus pneumoniae R6	96.372	100	0.964
comD	Streptococcus mitis SK321	91.61	100	0.916
comD	Streptococcus mitis NCTC 12261	86.395	100	0.864
comD/comD2	Streptococcus gordonii strain NCTC7865	49.202	85.261	0.42
comD/comD1	Streptococcus gordonii str. Challis substr. CH1	49.465	84.807	0.419