Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaR   Type   Regulator
Locus tag   HPE50_RS21690 Genome accession   NZ_CP054353
Coordinates   4381700..4382359 (+) Length   219 a.a.
NCBI ID   WP_001221493.1    Uniprot ID   Q3YXL4
Organism   Escherichia coli strain SCU-172     
Function   repress competence development; post-transcriptional repression of CSP production (predicted from homology)   
Competence regulation

Genomic Context

Location: 4376700..4387359
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  HPE50_RS21665 (HPE50_21660) - 4377972..4378181 (-) 210 Protein_4292 TRAP transporter large permease subunit -
  HPE50_RS21675 (HPE50_21670) ygiS 4378911..4380512 (-) 1602 WP_001571929.1 ABC transporter substrate-binding protein -
  HPE50_RS21680 (HPE50_21675) ygiV 4380621..4381103 (-) 483 WP_000183492.1 GyrI-like domain-containing protein -
  HPE50_RS21685 (HPE50_21680) ygiW 4381156..4381548 (-) 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
  HPE50_RS21690 (HPE50_21685) ciaR 4381700..4382359 (+) 660 WP_001221493.1 quorum sensing response regulator transcription factor QseB Regulator
  HPE50_RS21695 (HPE50_21690) qseC 4382356..4383705 (+) 1350 WP_001571931.1 quorum sensing histidine kinase QseC -
  HPE50_RS21700 (HPE50_21695) mdaB 4383815..4384396 (+) 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
  HPE50_RS21705 (HPE50_21700) ygiN 4384427..4384741 (+) 315 WP_000633738.1 putative quinol monooxygenase -
  HPE50_RS21710 (HPE50_21705) - 4384786..4385673 (-) 888 WP_000614943.1 MurR/RpiR family transcriptional regulator -
  HPE50_RS21715 (HPE50_21710) - 4385670..4386617 (-) 948 WP_001296418.1 iron-siderophore ABC transporter substrate-binding protein -

Sequence

Protein


Download         Length: 219 a.a.        Molecular weight: 24687.63 Da        Isoelectric Point: 6.9850

>NTDB_id=398995 HPE50_RS21690 WP_001221493.1 4381700..4382359(+) (ciaR) [Escherichia coli strain SCU-172]
MRILLIEDDMLIGDGIKTGLSKMGFSVDWFTQGRQGKEALYSAPYDAVILDLTLPGMDGRDILREWREKGQREPVLILTA
RDALAERVEGLRLGADDYLCKPFALIEVAARLEALMRRTNGQASNELRHGNVMLDPGKRIATLAGEPLTLKPKEFALLEL
LMRNAGRVLPRKLIEEKLYTWDEEVTSNAVEVHVHHLRRKLGSDFIRTVHGIGYTLGEK

Nucleotide


Download         Length: 660 bp        

>NTDB_id=398995 HPE50_RS21690 WP_001221493.1 4381700..4382359(+) (ciaR) [Escherichia coli strain SCU-172]
ATGCGAATTTTACTGATAGAAGATGACATGCTGATTGGCGACGGCATCAAAACGGGCCTTAGTAAAATGGGTTTTAGCGT
CGACTGGTTTACACAAGGTCGTCAGGGAAAAGAGGCGCTATATAGCGCACCTTATGATGCGGTGATCCTGGATTTAACCT
TACCGGGCATGGATGGTCGCGATATTTTGCGCGAATGGCGAGAAAAAGGTCAGCGTGAGCCGGTTTTGATCCTGACCGCG
CGCGATGCGCTGGCGGAACGTGTAGAAGGGCTGCGTCTGGGAGCTGACGATTATCTGTGTAAACCTTTTGCGTTGATAGA
AGTCGCCGCCAGGCTGGAAGCTCTGATGCGCCGAACCAACGGCCAGGCCAGCAACGAGCTGCGCCACGGCAACGTCATGC
TCGACCCCGGCAAACGTATCGCCACGCTGGCTGGCGAACCCTTAACGCTGAAGCCAAAAGAATTTGCCCTGCTGGAATTA
CTGATGCGTAACGCTGGTCGGGTACTGCCGCGCAAACTGATTGAAGAGAAACTGTATACCTGGGACGAAGAGGTCACCAG
TAATGCCGTTGAAGTGCATGTGCATCATCTGCGACGCAAACTCGGCAGTGATTTTATTCGTACCGTTCATGGTATTGGCT
ACACATTAGGTGAGAAATGA

Domains

Predicted by InterProScan.

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(145-216)

Response regulator receiver domain (Response_reg)

(3-112)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB Q3YXL4

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaR Streptococcus pneumoniae Rx1

38.326

100

0.397
  ciaR Streptococcus pneumoniae D39

38.326

100

0.397
  ciaR Streptococcus pneumoniae R6

38.326

100

0.397
  ciaR Streptococcus pneumoniae TIGR4

38.326

100

0.397
  ciaR Streptococcus mutans UA159

35.874

100

0.365