Detailed information    

insolico Bioinformatically predicted

Overview

Name   hexB   Type   Machinery gene
Locus tag   HRE60_RS00315 Genome accession   NZ_CP054153
Coordinates   53280..55217 (+) Length   645 a.a.
NCBI ID   WP_181670841.1    Uniprot ID   -
Organism   Streptococcus salivarius strain DB-B5     
Function   DNA mismatch repair (predicted from homology)   
Homologous recombination

Genomic Context

Location: 48280..60217
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  HRE60_RS00285 (HRE60_00285) argR 48485..48913 (+) 429 WP_171963651.1 arginine repressor -
  HRE60_RS00290 (HRE60_00290) - 48913..49272 (+) 360 WP_002889586.1 YlbF family regulator -
  HRE60_RS00295 (HRE60_00295) hexA 49265..51823 (+) 2559 WP_181670840.1 DNA mismatch repair protein MutS Machinery gene
  HRE60_RS00300 (HRE60_00300) - 51857..52312 (-) 456 WP_004181953.1 DUF3021 domain-containing protein -
  HRE60_RS00305 (HRE60_00305) - 52309..52746 (-) 438 WP_118189691.1 LytTR family DNA-binding domain-containing protein -
  HRE60_RS00310 (HRE60_00310) - 52925..53230 (+) 306 WP_048674007.1 hypothetical protein -
  HRE60_RS00315 (HRE60_00315) hexB 53280..55217 (+) 1938 WP_181670841.1 DNA mismatch repair endonuclease MutL Machinery gene
  HRE60_RS00320 (HRE60_00320) - 55348..55569 (+) 222 WP_002886321.1 hypothetical protein -
  HRE60_RS00325 (HRE60_00325) ruvA 55727..56317 (+) 591 WP_004181981.1 Holliday junction branch migration protein RuvA Machinery gene
  HRE60_RS00330 (HRE60_00330) - 56326..56880 (+) 555 WP_004181971.1 DNA-3-methyladenine glycosylase I -
  HRE60_RS00335 (HRE60_00335) cinA 56977..58242 (+) 1266 WP_181670842.1 competence/damage-inducible protein A Machinery gene
  HRE60_RS00340 (HRE60_00340) recA 58283..59422 (+) 1140 WP_002886327.1 recombinase RecA Machinery gene
  HRE60_RS00345 (HRE60_00345) spx 59592..59990 (+) 399 WP_002886328.1 transcriptional regulator Spx -

Sequence

Protein


Download         Length: 645 a.a.        Molecular weight: 72288.31 Da        Isoelectric Point: 5.2797

>NTDB_id=397476 HRE60_RS00315 WP_181670841.1 53280..55217(+) (hexB) [Streptococcus salivarius strain DB-B5]
MPKIIELPEVLANQIAAGEVVERPASVVKELVENAIDAGSTQITIEVEESGLSKIQITDNGEGMAQADVAMSLRRHATSK
IKNQGDLFRIRTLGFRGEALPSIASISHLTIVTAADGEAYGTKLVAKGGEIESQDPISTPVGTKITVENLFYNTPARLKY
MKSLQAELAHIVDVVNRLSLAHPEVAFTLLNDGRQLTQTSGTGDLRQAIAGIYGLTTAKKMVEISNSDLDFEVSGYVSLP
ELTRANRNYITILINGRYIKNFLLNRAIFDGYGSKLMVGRFPIAVIDIQIDPYLADVNVHPTKQEVRISKEKELMALISS
AIAQSLREQDLIPDALENLAKSSTRGATKPVQTSLPLKQTNLYYDSSRNDFFVKPETVQEDIKPLVSESPVSSVENKPQP
SVKQAQRSADEGDSEHEKLDYKNKSKMKRMLENLDNEETSTFPELEFFGQMHGTYLFAQGQGGLYIIDQHAAQERVKYEY
YREKIGEVDSSLQQLLVPYLFEFSGSDYISLQEKMSLLNQVGIYLEPYGNNTFILREHPIWMKEEEIESAVYEMCDMLLL
TNEVSVKTYRAELAIMMSCKRSIKANHALDDYSARDLLVQLAQCKNPYNCPHGRPVLVNFTKSDMEKMFRRIQENHTSLR
DLGKY

Nucleotide


Download         Length: 1938 bp        

>NTDB_id=397476 HRE60_RS00315 WP_181670841.1 53280..55217(+) (hexB) [Streptococcus salivarius strain DB-B5]
ATGCCAAAAATCATCGAATTGCCAGAGGTGTTAGCCAACCAGATTGCTGCTGGTGAGGTCGTAGAGCGTCCAGCTAGTGT
TGTCAAAGAGTTGGTGGAAAATGCTATTGATGCAGGTAGCACCCAGATTACCATTGAAGTTGAAGAATCAGGCCTCTCAA
AAATTCAAATAACAGACAATGGTGAAGGAATGGCTCAAGCTGATGTGGCCATGAGTTTGCGCCGTCATGCAACAAGTAAA
ATCAAAAATCAAGGAGATCTCTTTCGTATTCGAACCCTTGGTTTTCGAGGTGAGGCCCTTCCCTCTATAGCTTCTATCAG
TCACCTAACTATTGTGACAGCAGCGGATGGGGAAGCCTACGGGACTAAACTGGTTGCTAAAGGTGGAGAAATTGAGAGTC
AGGACCCTATTTCAACACCAGTTGGAACAAAGATTACCGTTGAAAACCTATTTTATAATACCCCAGCTCGTCTCAAGTAT
ATGAAGAGTTTACAGGCTGAGTTGGCTCATATTGTCGATGTTGTCAATCGTCTGAGTCTAGCTCATCCCGAGGTTGCCTT
TACCTTGCTTAATGATGGTCGTCAGTTGACACAGACATCAGGTACTGGAGACCTCCGTCAAGCTATTGCTGGTATTTATG
GTTTGACAACGGCTAAAAAAATGGTGGAGATTTCAAATTCTGACCTTGATTTTGAAGTTTCTGGTTATGTTAGTCTCCCT
GAGTTGACCCGTGCTAACCGTAATTACATCACGATTCTCATTAACGGACGCTATATTAAAAACTTCCTGCTTAACCGTGC
TATTTTTGATGGTTATGGTTCTAAACTCATGGTAGGACGCTTCCCTATTGCGGTTATTGATATTCAAATTGATCCCTACT
TGGCCGATGTCAATGTTCACCCAACAAAGCAGGAAGTACGTATCTCTAAAGAAAAAGAGCTTATGGCCCTTATCAGCTCT
GCCATTGCTCAAAGCCTTAGAGAGCAGGATTTGATTCCTGATGCTCTTGAAAATCTAGCCAAGTCAAGTACTAGAGGTGC
AACTAAGCCAGTCCAAACCAGTCTCCCACTTAAACAAACCAATCTTTACTATGATAGCAGTCGTAATGATTTCTTTGTCA
AACCAGAGACGGTCCAAGAGGATATCAAACCACTCGTATCAGAGTCTCCAGTTTCATCGGTAGAAAACAAACCGCAACCT
TCTGTTAAACAGGCACAGCGTTCAGCAGATGAAGGTGATAGCGAACACGAAAAACTTGATTATAAAAACAAGTCGAAAAT
GAAGCGCATGCTTGAAAATCTGGACAATGAGGAAACATCAACCTTCCCTGAGTTGGAGTTTTTTGGTCAAATGCATGGAA
CCTATCTCTTTGCGCAAGGACAAGGCGGACTTTACATCATTGACCAGCATGCTGCCCAAGAACGTGTCAAGTATGAGTAC
TATCGCGAAAAGATTGGTGAGGTTGACAGCAGTTTACAGCAGCTTTTGGTTCCCTATCTCTTTGAATTTTCAGGTTCAGA
CTACATTAGTTTACAAGAAAAAATGTCCCTTCTTAACCAGGTTGGTATCTATTTAGAGCCTTATGGGAACAACACTTTCA
TTCTTCGTGAACATCCTATCTGGATGAAGGAAGAAGAGATTGAATCAGCGGTCTATGAAATGTGTGACATGCTTCTTTTG
ACGAATGAAGTGTCTGTTAAGACCTACCGTGCTGAGTTGGCCATCATGATGAGTTGTAAACGTTCAATCAAGGCCAATCA
TGCTCTTGATGATTACTCTGCGCGTGACCTCCTAGTACAGCTTGCACAGTGTAAAAATCCCTACAATTGCCCTCACGGAC
GTCCAGTACTTGTCAACTTTACCAAGTCTGATATGGAAAAAATGTTCCGTCGTATCCAAGAAAATCATACAAGTCTACGT
GACCTAGGGAAGTATTAA

Domains

Predicted by InterProScan.

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c_3)

(25-124)

MutL C terminal dimerisation domain (MutL_C)

(446-589)

DNA mismatch repair protein, C-terminal domain (DNA_mis_repair)

(209-326)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  hexB Streptococcus pneumoniae R6

69.725

100

0.707