Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaR   Type   Regulator
Locus tag   HHJ21_RS18335 Genome accession   NZ_CP051753
Coordinates   3895101..3895760 (+) Length   219 a.a.
NCBI ID   WP_001221493.1    Uniprot ID   Q3YXL4
Organism   Escherichia coli strain SCU-102     
Function   repress competence development; post-transcriptional repression of CSP production (predicted from homology)   
Competence regulation

Genomic Context

Location: 3890101..3900760
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  HHJ21_RS18315 (HHJ21_18310) plsC 3890247..3890984 (-) 738 WP_000965712.1 1-acylglycerol-3-phosphate O-acyltransferase -
  HHJ21_RS18320 (HHJ21_18315) parC 3891218..3893476 (-) 2259 WP_001281890.1 DNA topoisomerase IV subunit A -
  HHJ21_RS18325 (HHJ21_18320) ygiV 3894022..3894504 (-) 483 WP_000183504.1 GyrI-like domain-containing protein -
  HHJ21_RS18330 (HHJ21_18325) ygiW 3894557..3894949 (-) 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
  HHJ21_RS18335 (HHJ21_18330) ciaR 3895101..3895760 (+) 660 WP_001221493.1 quorum sensing response regulator transcription factor QseB Regulator
  HHJ21_RS18340 (HHJ21_18335) qseC 3895757..3897106 (+) 1350 WP_000673385.1 quorum sensing histidine kinase QseC -
  HHJ21_RS18345 (HHJ21_18340) mdaB 3897216..3897797 (+) 582 WP_000072420.1 NADPH:quinone oxidoreductase MdaB -
  HHJ21_RS18350 (HHJ21_18345) ygiN 3897828..3898142 (+) 315 WP_000958598.1 putative quinol monooxygenase -
  HHJ21_RS18355 (HHJ21_18350) - 3898187..3899074 (-) 888 WP_000612360.1 MurR/RpiR family transcriptional regulator -
  HHJ21_RS18360 (HHJ21_18355) - 3899071..3900018 (-) 948 WP_001305988.1 iron-siderophore ABC transporter substrate-binding protein -

Sequence

Protein


Download         Length: 219 a.a.        Molecular weight: 24687.63 Da        Isoelectric Point: 6.9850

>NTDB_id=388026 HHJ21_RS18335 WP_001221493.1 3895101..3895760(+) (ciaR) [Escherichia coli strain SCU-102]
MRILLIEDDMLIGDGIKTGLSKMGFSVDWFTQGRQGKEALYSAPYDAVILDLTLPGMDGRDILREWREKGQREPVLILTA
RDALAERVEGLRLGADDYLCKPFALIEVAARLEALMRRTNGQASNELRHGNVMLDPGKRIATLAGEPLTLKPKEFALLEL
LMRNAGRVLPRKLIEEKLYTWDEEVTSNAVEVHVHHLRRKLGSDFIRTVHGIGYTLGEK

Nucleotide


Download         Length: 660 bp        

>NTDB_id=388026 HHJ21_RS18335 WP_001221493.1 3895101..3895760(+) (ciaR) [Escherichia coli strain SCU-102]
ATGCGAATTTTACTGATAGAAGATGACATGCTGATTGGTGACGGCATCAAAACGGGCCTTAGTAAAATGGGTTTTAGCGT
CGACTGGTTTACACAAGGTCGTCAGGGAAAAGAAGCGCTATATAGCGCGCCTTATGATGCGGTGATCCTGGATTTAACCT
TACCAGGCATGGATGGTCGCGATATTTTGCGCGAATGGCGAGAAAAAGGTCAGCGTGAGCCGGTACTGATCCTGACCGCG
CGCGATGCGCTGGCGGAACGTGTAGAGGGGCTGCGTCTGGGAGCTGACGATTATCTGTGTAAACCTTTTGCGTTGATAGA
AGTCGCCGCCAGGCTGGAAGCTCTGATGCGCCGAACCAACGGCCAGGCCAGCAACGAACTGCGCCACGGTAACGTCATGC
TCGACCCCGGCAAACGTATCGCCACGCTGGCTGGCGAACCCTTAACGCTGAAACCAAAAGAATTTGCCCTGCTGGAATTA
CTGATGCGTAACGCTGGTCGGGTACTGCCGCGCAAACTGATTGAAGAGAAACTGTATACCTGGGACGAAGAGGTCACCAG
TAATGCCGTTGAAGTACATGTGCATCATCTGCGACGCAAACTCGGCAGTGATTTTATTCGTACCGTTCATGGTATTGGCT
ACACATTAGGTGAGAAATGA

Domains

Predicted by InterProScan.

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(145-216)

Response regulator receiver domain (Response_reg)

(3-112)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB Q3YXL4

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaR Streptococcus pneumoniae Rx1

38.326

100

0.397
  ciaR Streptococcus pneumoniae D39

38.326

100

0.397
  ciaR Streptococcus pneumoniae R6

38.326

100

0.397
  ciaR Streptococcus pneumoniae TIGR4

38.326

100

0.397
  ciaR Streptococcus mutans UA159

35.874

100

0.365