Detailed information NTG0385862

Bioinformatically predicted

Overview

• Name: crp
• Type: Regulator
• Locus tag: F1539_RS09955
• Genome accession: NZ_CP043772
• Coordinates: 1960332..1961006 (+)
• Length: 224 a.a.
• NCBI ID: WP_005647998.1
• Uniprot ID: Q4QLV0
• Organism: Haemophilus influenzae biotype aegyptius strain HE24/F3037
• Function: promote expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1955332..1966006

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
F1539_RS09920 (F1539_09925)	rpmG	1956249..1956419 (-)	171	WP_005613503.1	50S ribosomal protein L33	-
F1539_RS09925 (F1539_09930)	rpmB	1956431..1956667 (-)	237	WP_005542826.1	50S ribosomal protein L28	-
F1539_RS09930 (F1539_09935)	radC	1956881..1957546 (-)	666	WP_013526173.1	DNA repair protein RadC	-
F1539_RS09935 (F1539_09940)	coaBC	1957709..1958911 (+)	1203	WP_011272308.1	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase CoaBC	-
F1539_RS09940 (F1539_09945)	dut	1958959..1959414 (+)	456	WP_005631431.1	dUTP diphosphatase	-
F1539_RS09945 (F1539_09950)	slmA	1959418..1960074 (+)	657	WP_005648000.1	nucleoid occlusion factor SlmA	-
F1539_RS09950 (F1539_09955)	-	1960096..1960347 (+)	252	WP_005647999.1	YheU family protein	-
F1539_RS09955 (F1539_09960)	crp	1960332..1961006 (+)	675	WP_005647998.1	cAMP-activated global transcriptional regulator CRP	Regulator
F1539_RS09960 (F1539_09965)	rumB	1961371..1961805 (-)	435	Protein_1918	23S rRNA (uracil(747)-C(5))-methyltransferase	-
F1539_RS09965 (F1539_09970)	-	1962398..1963114 (-)	717	WP_013526172.1	S24 family peptidase	-
F1539_RS09970 (F1539_09975)	-	1963290..1963568 (+)	279	WP_041174962.1	helix-turn-helix domain-containing protein	-
F1539_RS09975 (F1539_09980)	-	1963612..1965597 (+)	1986	WP_013526171.1	Mu transposase C-terminal domain-containing protein	-
F1539_RS09980 (F1539_09985)	-	1965608..1966006 (+)	399	WP_032826358.1	hypothetical protein	-

Sequence

Protein

• Length: 224 a.a.
• Molecular weight: 25151.85 Da
• Isoelectric Point: 6.8375

>NTDB_id=385862 F1539_RS09955 WP_005647998.1 1960332..1961006(+) (crp) [Haemophilus influenzae biotype aegyptius strain HE24/F3037]
MSNELTEIDEVVTSSQEEATQRDPVLDWFLTHCHLHKYPAKSTLIHAGEDATTLYYVIKGSVMVSSKDDEGKEMILTYLG
AGQFFGEAGLFDEGSKRSAWVKTKTTCEIAEISYKKYRQLIQANPEILMFLTAQLARRLQNTSRQVTNLAFLDVAGRIAQ
TLMNLAKQPEAMTHPDGMQIKITRQEIGQMVGCSRETVGRIIKMLEDQNLIHAHGKTIVVYGAR

Nucleotide

• Length: 675 bp

>NTDB_id=385862 F1539_RS09955 WP_005647998.1 1960332..1961006(+) (crp) [Haemophilus influenzae biotype aegyptius strain HE24/F3037]
ATGTCAAATGAATTAACCGAAATTGATGAAGTTGTAACCTCCTCTCAAGAAGAAGCAACTCAACGAGATCCCGTTTTAGA
TTGGTTTCTTACTCACTGCCATTTGCATAAATATCCTGCAAAATCAACTTTAATTCATGCTGGGGAAGATGCGACCACGC
TGTATTATGTAATTAAAGGTTCTGTAATGGTATCTTCAAAAGATGATGAAGGCAAAGAGATGATCCTCACTTACTTAGGA
GCAGGACAATTTTTTGGCGAAGCGGGATTATTTGATGAAGGTTCAAAACGATCAGCTTGGGTAAAAACAAAAACAACATG
TGAAATTGCTGAAATTTCCTATAAGAAATATCGCCAGTTGATTCAGGCAAACCCTGAAATCTTAATGTTTCTCACTGCAC
AATTGGCAAGACGTTTGCAAAATACATCACGTCAAGTCACGAATTTGGCATTTTTAGACGTCGCAGGTCGCATCGCTCAA
ACTTTAATGAACTTAGCTAAACAGCCTGAAGCAATGACGCATCCTGATGGTATGCAAATCAAAATTACACGCCAAGAAAT
AGGGCAAATGGTGGGTTGTTCACGAGAAACTGTGGGGCGCATTATTAAGATGTTGGAGGATCAGAATCTTATCCACGCTC
ATGGAAAAACAATCGTTGTATATGGCGCAAGATAA

Domains

Predicted by InterproScan.

• Cyclic nucleotide-binding domain (cNMP_binding) (36-124)

• Crp-like helix-turn-helix domain (HTH_Crp_2) (156-220)

3D structure

• AlphaFold DB: Q4QLV0

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
crp	Haemophilus influenzae Rd KW20	100	100	1
crp	Vibrio cholerae strain A1552	75.49	91.071	0.687
crp	Acinetobacter baumannii D1279779	48.705	86.161	0.42