Detailed information    

insolico Bioinformatically predicted

Overview

Name   hexB   Type   Machinery gene
Locus tag   HBA50_RS00640 Genome accession   NZ_CP050133
Coordinates   126379..128322 (+) Length   647 a.a.
NCBI ID   WP_045500183.1    Uniprot ID   -
Organism   Streptococcus cristatus ATCC 51100     
Function   DNA mismatch repair (predicted from homology)   
Homologous recombination

Genomic Context

Location: 121379..133322
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  HBA50_RS00615 (HBA50_00615) argR 122032..122472 (+) 441 WP_045500171.1 arginine repressor -
  HBA50_RS00620 (HBA50_00620) hexA 122546..125095 (+) 2550 WP_045500174.1 DNA mismatch repair protein MutS Machinery gene
  HBA50_RS00630 (HBA50_00630) - 125287..125757 (-) 471 WP_045500176.1 DUF3021 family protein -
  HBA50_RS00635 (HBA50_00635) brsR 125754..126194 (-) 441 WP_045500179.1 LytTR family DNA-binding domain-containing protein Regulator
  HBA50_RS00640 (HBA50_00640) hexB 126379..128322 (+) 1944 WP_045500183.1 DNA mismatch repair endonuclease MutL Machinery gene
  HBA50_RS00645 (HBA50_00645) - 128358..128879 (-) 522 WP_045500186.1 RDD family protein -
  HBA50_RS00650 (HBA50_00650) - 128863..129369 (-) 507 WP_045500189.1 helix-turn-helix domain-containing protein -
  HBA50_RS00655 (HBA50_00655) ruvA 129539..130129 (+) 591 WP_045500192.1 Holliday junction branch migration protein RuvA Machinery gene
  HBA50_RS00660 (HBA50_00660) - 130139..130693 (+) 555 WP_045500195.1 DNA-3-methyladenine glycosylase I -
  HBA50_RS00665 (HBA50_00665) - 130698..131351 (+) 654 WP_045500198.1 CPBP family intramembrane glutamic endopeptidase -
  HBA50_RS00670 (HBA50_00670) - 131435..131992 (+) 558 WP_045500201.1 GNAT family N-acetyltransferase -
  HBA50_RS00675 (HBA50_00675) - 132036..132446 (-) 411 WP_045500205.1 helix-turn-helix domain-containing protein -

Sequence

Protein


Download         Length: 647 a.a.        Molecular weight: 73261.50 Da        Isoelectric Point: 5.2429

>NTDB_id=376856 HBA50_RS00640 WP_045500183.1 126379..128322(+) (hexB) [Streptococcus cristatus ATCC 51100]
MSKIIELPEILANQIAAGEVIERPSSVVKELVENSIDAGASQITIEIEEAGLKSIQVTDNGEGIDHEDVPLALRRHATSK
IKKQADLFRIRTLGFRGEAIPSIASVSRFTIETATEAGQHGTLLVAQGGEIEKHEPTSSPVGTKIKVEDLFFNTPARLKY
MKSQQAELSHIVDVINRLSLAHPEVAFTLISDGREMTRTAGSGNLRQAIAGIYGLATAKKMVEISASDLDFEVSGYVSLP
ELTRANRNYITILINGRYIKNFLLNRAILDGYGSKLMVGRFPLAVINIQIDPYLADVNVHPTKQEVRISKERELMALISQ
AIATSLKEQDLIPDALENLAKSTVKRATKPEQTSLPLKENRLYYDKEQNDFFLKPQVAEQQLSFEELAKPVHQATDEKAE
PQPTSVKFAERKPVSYDQLDHPELDQASLERAVDKLEQEEKSSFPELEYFGQMHGTYLFAQGKGGLYIIDQHAAQERVKY
EYYREKIGDVDNSQQQLLVPYIFEFPADDMLRIKQRMELLEDAGIFLEEYGANQFILREHPIWFKEEEIEAGIYEMCDML
LLTKEVSIKKYRAELAIMMSCKRSIKANHSLDDYSARDLLFQLSQCDNPYNCPHGRPVLVNFTKSDMEKMFRRIQENHTS
LRELGKY

Nucleotide


Download         Length: 1944 bp        

>NTDB_id=376856 HBA50_RS00640 WP_045500183.1 126379..128322(+) (hexB) [Streptococcus cristatus ATCC 51100]
ATGTCAAAAATTATCGAACTTCCAGAAATTCTAGCCAATCAGATTGCGGCAGGTGAGGTCATTGAGCGGCCTAGCAGCGT
GGTCAAGGAGCTAGTGGAAAATTCAATTGATGCGGGTGCTAGTCAGATTACCATCGAAATCGAGGAGGCCGGACTCAAGA
GCATTCAGGTGACGGATAATGGCGAGGGCATAGACCACGAAGATGTCCCTCTGGCCCTCCGCCGCCATGCTACCAGTAAA
ATCAAGAAGCAGGCGGATCTCTTTCGGATTCGGACATTGGGTTTCCGAGGCGAGGCCATTCCTTCCATTGCTTCTGTCTC
GCGTTTTACCATTGAGACAGCGACGGAAGCTGGCCAGCACGGGACTCTGCTGGTTGCGCAGGGTGGCGAGATAGAAAAGC
ACGAACCTACCAGCAGTCCGGTGGGAACGAAAATCAAGGTAGAAGATCTCTTCTTTAATACTCCAGCCCGGCTCAAGTAT
ATGAAGAGCCAGCAGGCTGAGCTATCCCACATCGTTGATGTGATTAATCGGCTTAGTCTGGCCCATCCGGAAGTGGCTTT
CACCCTTATCAGCGACGGCCGCGAAATGACACGGACTGCCGGCAGTGGTAATCTGCGTCAGGCTATTGCAGGAATCTATG
GTTTGGCAACAGCTAAGAAAATGGTGGAAATCTCTGCTTCAGATTTGGACTTTGAAGTGAGCGGCTATGTCAGCCTGCCT
GAGTTGACTCGTGCGAATCGGAATTATATTACGATTCTCATCAACGGCCGCTACATTAAGAATTTCCTGCTCAATCGAGC
TATTTTGGACGGCTACGGCAGCAAGCTGATGGTAGGTCGCTTTCCACTAGCGGTCATCAATATTCAGATTGACCCCTATC
TAGCCGATGTCAATGTCCATCCGACCAAGCAAGAGGTGCGCATTTCTAAAGAACGCGAACTCATGGCCTTGATTTCGCAA
GCCATTGCGACTAGTCTCAAGGAGCAGGACCTTATCCCAGATGCTTTGGAAAATCTAGCCAAATCAACTGTTAAGCGTGC
GACTAAGCCCGAACAGACTAGTCTTCCCCTTAAAGAAAATCGCCTCTACTACGATAAGGAGCAGAATGACTTCTTCCTCA
AGCCGCAGGTGGCCGAGCAGCAACTATCCTTTGAAGAATTAGCAAAGCCTGTTCATCAAGCGACAGATGAAAAAGCAGAA
CCGCAACCGACTTCGGTCAAATTTGCAGAGAGAAAGCCAGTTAGCTATGACCAACTAGACCATCCAGAGCTTGACCAGGC
TAGTCTGGAGCGGGCTGTGGATAAGTTGGAGCAGGAAGAGAAATCAAGCTTCCCAGAGTTAGAATATTTCGGTCAGATGC
ATGGTACTTATCTCTTTGCTCAGGGCAAGGGCGGTCTTTATATTATTGACCAGCATGCTGCCCAAGAGCGGGTCAAGTAT
GAGTATTATCGGGAGAAGATTGGGGATGTGGACAATAGCCAGCAGCAGCTTTTAGTGCCCTATATCTTTGAATTTCCAGC
GGACGATATGCTGCGAATCAAGCAGCGGATGGAGCTATTAGAAGATGCTGGTATATTTTTAGAAGAGTATGGAGCCAATC
AGTTTATCCTCCGTGAGCACCCCATTTGGTTTAAGGAAGAGGAGATTGAGGCAGGCATCTATGAGATGTGTGATATGCTG
CTCTTGACCAAGGAAGTTTCCATCAAGAAATATCGAGCAGAGCTGGCCATTATGATGAGCTGCAAACGCTCCATCAAGGC
CAATCACAGTCTGGATGACTATTCTGCGCGTGACTTGCTCTTTCAGCTGTCCCAGTGTGACAATCCCTATAACTGCCCAC
ACGGCCGGCCGGTCTTGGTCAACTTTACCAAGTCGGATATGGAAAAAATGTTCCGCCGCATTCAGGAAAATCATACTAGC
CTACGGGAGTTGGGGAAATACTAA

Domains

Predicted by InterProScan.

MutL C terminal dimerisation domain (MutL_C)

(449-591)

DNA mismatch repair protein, C-terminal domain (DNA_mis_repair)

(209-326)

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c_3)

(25-116)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  hexB Streptococcus pneumoniae R6

77.812

100

0.781