Detailed information NTG0376854

Bioinformatically predicted

Overview

• Name: hexA
• Type: Machinery gene
• Locus tag: HBA50_RS00620
• Genome accession: NZ_CP050133
• Coordinates: 122546..125095 (+)
• Length: 849 a.a.
• NCBI ID: WP_045500174.1
• Uniprot ID: -
• Organism: Streptococcus cristatus ATCC 51100
• Function: DNA mismatch repair (predicted from homology) Homologous recombination

Genomic Context

Location: 117546..130095

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
HBA50_RS00595 (HBA50_00595)	-	118796..119314 (+)	519	WP_045500162.1	hypothetical protein	-
HBA50_RS00600 (HBA50_00600)	nrdI	119392..119853 (+)	462	WP_152621717.1	class Ib ribonucleoside-diphosphate reductase assembly flavoprotein NrdI	-
HBA50_RS00605 (HBA50_00605)	-	119900..120166 (-)	267	WP_045500165.1	hypothetical protein	-
HBA50_RS00610 (HBA50_00610)	argS	120218..121906 (-)	1689	WP_045500168.1	arginine--tRNA ligase	-
HBA50_RS00615 (HBA50_00615)	argR	122032..122472 (+)	441	WP_045500171.1	arginine repressor	-
HBA50_RS00620 (HBA50_00620)	hexA	122546..125095 (+)	2550	WP_045500174.1	DNA mismatch repair protein MutS	Machinery gene
HBA50_RS00630 (HBA50_00630)	-	125287..125757 (-)	471	WP_045500176.1	DUF3021 family protein	-
HBA50_RS00635 (HBA50_00635)	brsR	125754..126194 (-)	441	WP_045500179.1	LytTR family DNA-binding domain-containing protein	Regulator
HBA50_RS00640 (HBA50_00640)	hexB	126379..128322 (+)	1944	WP_045500183.1	DNA mismatch repair endonuclease MutL	Machinery gene
HBA50_RS00645 (HBA50_00645)	-	128358..128879 (-)	522	WP_045500186.1	RDD family protein	-
HBA50_RS00650 (HBA50_00650)	-	128863..129369 (-)	507	WP_045500189.1	helix-turn-helix domain-containing protein	-

Sequence

Protein

• Length: 849 a.a.
• Molecular weight: 94895.22 Da
• Isoelectric Point: 4.8975

>NTDB_id=376854 HBA50_RS00620 WP_045500174.1 122546..125095(+) (hexA) [Streptococcus cristatus ATCC 51100]
MAVEKLSPGMQQYLDIKKDYPDAFLLFRMGDFYELFYDDAVNAAQILEISLTSRNKNAENPIPMAGVPYHSAQQYIDVLV
ESGYKVAIAEQMEDPKEAKGVVKREVVQVITPGTVVDSSKPDSANNFLVALDYSDGLYGLAYMDLVTGEFQVTSLEDFAL
VCGEIRNLKAREVVLGYALPEAEEQVLAGQMNLLLSYVQTALDDVQLLGEELSPMERQAAGKLLEYVHRTQMRELSHLKK
AQHYEIKDFLQMDYATKASLDLTENARSGKKHGSLYWLMDETKTAMGSRMLRSWIQRPLIDEARISQRQNVVEVFLDHFF
ERSDLTESLKGVYDIERLASRVSFGKTNPKDLLQLAATLGNVPQIKAILQGIDSPHLARLIEGLDPIPELAGLISSAISP
DAPHIITEGNIIRTGFDETLDQYRLVLREGTGWIAELEVKERANSGISNLKIDYNKKDGYYFHVTNSQLAHVPSHFFRKA
TLKNSERFGTEELARIEGEMLEAREKSANLEYEIFMRIREEAGKYIQRLQALAQTLAAVDVLQSFAAVAEQQHLVRPVFT
AERRLQIEKGRHPVVEKVMGAQSYIPNSILLDQETDIQLITGPNMSGKSTYMRQLAIIVIMAQMGSYVPAQSASLPVFDA
IFTRIGAADDLVSGQSTFMVEMMEANRAIRQASDRSLILFDELGRGTATYDGMALAQAIIEHIHHYTGAKTLFATHYHEL
TALEDSLEHLENVHVATLEKDGQVTFLHKIEPGPADKSYGIHVAKIAGLPEKLLERADSILSHLESQNKGLDSELPDGSL
QKQPQVAEQMSLFAEGSENPVLTELRDLDIYNMTPLEVMAAVAELKKKL

Nucleotide

• Length: 2550 bp

>NTDB_id=376854 HBA50_RS00620 WP_045500174.1 122546..125095(+) (hexA) [Streptococcus cristatus ATCC 51100]
ATGGCAGTAGAAAAGTTATCGCCAGGCATGCAGCAGTATTTGGATATCAAAAAGGACTATCCAGATGCTTTCTTGCTCTT
TCGGATGGGGGATTTCTATGAGTTGTTTTATGATGATGCGGTCAATGCCGCCCAGATTTTAGAGATTTCTCTCACCAGCC
GCAATAAAAATGCAGAAAATCCCATTCCCATGGCTGGAGTTCCCTATCATTCGGCACAGCAATATATTGATGTTTTGGTC
GAATCAGGCTATAAGGTAGCGATTGCGGAGCAGATGGAAGATCCCAAGGAAGCCAAGGGAGTTGTTAAGCGGGAGGTCGT
TCAGGTTATCACGCCGGGAACGGTGGTGGACTCCAGTAAGCCGGACTCTGCTAATAACTTTCTGGTGGCTCTGGATTACT
CAGACGGCCTCTATGGTCTGGCTTATATGGACTTGGTGACTGGTGAGTTTCAGGTGACCAGTTTGGAGGACTTTGCCCTG
GTCTGCGGGGAAATTCGCAATTTGAAAGCTAGGGAAGTTGTGTTGGGCTATGCCTTGCCAGAAGCTGAGGAGCAGGTCTT
GGCTGGACAGATGAACCTCTTACTGTCCTATGTACAGACGGCCTTGGACGATGTCCAGCTGCTGGGCGAGGAGCTGTCTC
CTATGGAGCGTCAGGCAGCAGGGAAATTGCTGGAGTATGTGCACCGGACCCAGATGAGGGAACTCAGCCATTTGAAGAAG
GCCCAGCATTATGAAATTAAGGACTTTCTGCAAATGGATTATGCCACTAAGGCGAGTCTGGATTTGACAGAAAATGCTCG
TTCAGGCAAGAAGCACGGCAGTCTTTATTGGCTGATGGACGAGACCAAGACGGCCATGGGCAGTCGCATGCTGCGCTCTT
GGATCCAGCGTCCGCTGATTGATGAAGCGCGAATTAGCCAGCGGCAGAATGTCGTCGAGGTTTTTCTGGATCATTTCTTT
GAGCGGAGTGATTTGACGGAGAGCCTCAAGGGAGTCTATGATATCGAGCGGCTGGCTAGTCGAGTTTCTTTTGGTAAGAC
CAATCCCAAGGATCTGCTGCAGCTGGCAGCTACATTGGGCAACGTGCCTCAGATTAAGGCTATTCTGCAAGGGATCGACA
GTCCGCATCTAGCTCGTTTGATTGAGGGCTTGGATCCTATTCCAGAGTTGGCGGGCTTGATTAGCTCGGCCATTTCGCCA
GATGCACCTCATATCATCACCGAGGGCAATATCATTCGGACAGGTTTTGATGAGACCTTGGATCAATATCGGCTTGTGCT
GAGGGAGGGGACCGGGTGGATTGCGGAGCTGGAAGTCAAAGAACGTGCCAACAGCGGCATCAGCAATCTGAAGATTGATT
ACAATAAAAAAGATGGTTACTATTTCCACGTGACCAATTCCCAGCTGGCTCATGTGCCTAGCCATTTCTTCCGCAAGGCG
ACCCTGAAAAATTCGGAGCGTTTCGGAACGGAGGAGCTGGCACGAATTGAGGGAGAGATGTTGGAGGCGCGTGAAAAATC
TGCTAATCTGGAATACGAAATTTTCATGCGGATTCGCGAGGAAGCTGGCAAATACATCCAGCGCTTGCAGGCCTTGGCAC
AAACGCTGGCAGCTGTGGATGTCCTGCAGAGTTTTGCTGCGGTGGCAGAACAGCAGCATTTGGTGCGTCCCGTCTTTACT
GCGGAGCGCCGTCTGCAGATTGAAAAAGGCCGCCATCCTGTTGTGGAAAAGGTGATGGGTGCCCAAAGCTACATTCCAAA
TAGTATTCTGCTGGACCAGGAAACGGACATCCAGCTGATTACTGGGCCTAATATGAGTGGGAAATCGACCTATATGCGCC
AGCTGGCTATCATCGTTATTATGGCGCAGATGGGCTCTTATGTGCCCGCCCAGTCTGCCAGTCTGCCAGTATTTGACGCG
ATTTTCACTCGCATCGGTGCAGCGGATGATCTGGTGTCTGGCCAGTCCACCTTTATGGTGGAGATGATGGAGGCCAATCG
GGCCATTCGACAGGCCAGCGATCGTTCGCTCATTCTCTTTGATGAGCTGGGGCGTGGAACGGCGACTTATGATGGGATGG
CGCTGGCTCAAGCCATTATCGAGCATATTCATCATTATACTGGGGCCAAAACCCTCTTTGCCACCCACTATCACGAGCTG
ACAGCCTTGGAGGATAGTCTGGAGCATTTGGAAAATGTCCATGTGGCAACCTTGGAAAAGGACGGGCAGGTGACTTTCCT
GCATAAGATTGAGCCGGGTCCGGCTGACAAGTCCTACGGAATCCATGTAGCGAAGATTGCCGGACTTCCTGAGAAATTAC
TGGAGCGGGCGGATAGCATTTTGAGCCATTTGGAGAGTCAGAATAAAGGACTTGACTCAGAGCTTCCTGATGGAAGCCTA
CAAAAGCAGCCGCAAGTGGCGGAGCAGATGTCTCTTTTTGCAGAAGGATCGGAAAATCCAGTCCTGACTGAACTACGAGA
CTTGGACATCTACAATATGACTCCCCTGGAAGTCATGGCGGCGGTAGCCGAGCTCAAGAAGAAGTTGTAA

Domains

Predicted by InterProScan.

• MutS domain II (MutS_II) (126-239)

• MutS domain I (MutS_I) (8-118)

• MutS domain III (MutS_III) (256-546)

• MutS domain V (MutS_V) (599-785)

• MutS family domain IV (MutS_IV) (415-505)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
hexA	Streptococcus pneumoniae R6	77.385	100	0.774
mutS	Pseudomonas stutzeri strain ATCC 17587	38.856	100	0.392