Detailed information NTG0037602

Bioinformatically predicted

Overview

• Name: comE/blpR
• Type: Regulator
• Locus tag: HMPREF0837_RS03965
• Genome accession: NC_014251
• Coordinates: 754116..754853 (+)
• Length: 245 a.a.
• NCBI ID: WP_001219126.1
• Uniprot ID: A7XHJ0
• Organism: Streptococcus pneumoniae TCH8431/19A
• Function: activate transcription of early competence genes; regulation of comX expression (predicted from homology) Competence regulation

Genomic Context

Location: 749116..759853

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
HMPREF0837_RS03930	-	750092..750286 (-)	195	WP_001808905.1	hypothetical protein	-
HMPREF0837_RS03935 (HMPREF0837_10814)	-	750448..750735 (-)	288	WP_000777760.1	hypothetical protein	-
HMPREF0837_RS03940 (HMPREF0837_10815)	-	750745..751155 (-)	411	WP_001278301.1	HIT family protein	-
HMPREF0837_RS03945 (HMPREF0837_10816)	pptA	751223..751954 (+)	732	WP_000889923.1	ABC transporter ATP-binding protein	Regulator
HMPREF0837_RS03950 (HMPREF0837_10817)	-	751951..753000 (+)	1050	WP_000653752.1	ABC transporter permease	-
HMPREF0837_RS03955 (HMPREF0837_10818)	-	753168..753497 (-)	330	WP_000132575.1	hypothetical protein	-
HMPREF0837_RS03960 (HMPREF0837_10819)	-	753773..754111 (+)	339	WP_000682122.1	LytTR family DNA-binding domain-containing protein	-
HMPREF0837_RS03965 (HMPREF0837_10820)	comE/blpR	754116..754853 (+)	738	WP_001219126.1	response regulator transcription factor	Regulator
HMPREF0837_RS03970 (HMPREF0837_10821)	-	754866..756206 (+)	1341	WP_000275284.1	sensor histidine kinase	-
HMPREF0837_RS03975 (HMPREF0837_10822)	-	756446..757792 (-)	1347	WP_001821303.1	IS1380-like element ISSpn5 family transposase	-
HMPREF0837_RS03980 (HMPREF0837_10823)	blpC	757959..758114 (-)	156	WP_000358814.1	quorum-sensing system pheromone BlpC	-
HMPREF0837_RS03985 (HMPREF0837_10824)	-	758171..759532 (-)	1362	WP_001069099.1	bacteriocin secretion accessory protein	-

Sequence

Protein

• Length: 245 a.a.
• Molecular weight: 28752.92 Da
• Isoelectric Point: 6.2357

>NTDB_id=37602 HMPREF0837_RS03965 WP_001219126.1 754116..754853(+) (comE/blpR) [Streptococcus pneumoniae TCH8431/19A]
MRIFVLEDDFSQQTRIETTIEKLLKAHHIIPSSFEVFGKPDQLLAEVHEKGAHQLFFLDIEIRNEEMKGLEVARKIREQD
PYALIVFVTTHSEFMPLSFRYQVSALDYIDKALSAEEFESRIETALLYANSQDSKSLAEDCFYFKSKFAQFQYPFKEVYY
LETSPRPHRVILYTKTDRLEFTASLEEVFKQEPRLLQCHRSFLINPANVVHLDKKEKLLFFPNGGSCLIARYKVREVSEA
INNLH

Nucleotide

• Length: 738 bp

>NTDB_id=37602 HMPREF0837_RS03965 WP_001219126.1 754116..754853(+) (comE/blpR) [Streptococcus pneumoniae TCH8431/19A]
ATGAGAATATTTGTTTTAGAAGATGATTTTTCCCAACAGACTAGAATTGAAACGACGATTGAGAAACTTTTGAAAGCACA
TCATATCATTCCTAGCTCTTTTGAGGTATTTGGCAAGCCGGACCAACTGCTGGCAGAGGTGCATGAGAAGGGGGCCCATC
AGCTATTCTTTTTGGATATTGAGATTCGAAATGAAGAGATGAAGGGACTGGAAGTGGCTAGAAAGATTCGGGAACAAGAC
CCTTATGCCCTAATCGTCTTTGTGACGACTCACTCGGAGTTTATGCCTCTGTCCTTTCGCTACCAAGTGTCAGCTTTGGA
CTACATTGATAAGGCCCTTTCGGCAGAGGAGTTTGAATCTCGTATCGAGACAGCCCTCCTCTATGCCAATAGTCAAGATA
GTAAAAGTCTGGCGGAAGATTGCTTTTACTTTAAATCAAAATTTGCCCAATTCCAATATCCTTTCAAAGAGGTTTACTAT
CTCGAAACATCCCCAAGACCCCATCGTGTTATTCTCTATACCAAGACGGACAGGCTAGAATTTACGGCGAGTTTAGAGGA
GGTTTTTAAGCAGGAACCCCGTCTCTTGCAGTGCCATCGCTCTTTTCTCATCAATCCTGCAAATGTGGTGCATTTGGATA
AGAAAGAAAAACTCCTTTTCTTTCCCAATGGTGGAAGCTGTCTGATCGCGCGTTATAAGGTCAGGGAAGTGTCTGAGGCT
ATTAATAACTTACACTGA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (3-122)

• LytTr DNA-binding domain (LytTR) (151-241)

3D structure

• AlphaFold DB: A7XHJ0

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE/blpR	Streptococcus mutans UA159	53.909	99.184	0.535
comE/comE1	Streptococcus equinus JB1	43.882	96.735	0.424
comE/comE2	Streptococcus equinus JB1	38.843	98.776	0.384