Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaR   Type   Regulator
Locus tag   G6Q95_RS15260 Genome accession   NZ_CP049348
Coordinates   3237186..3237845 (+) Length   219 a.a.
NCBI ID   WP_001221502.1    Uniprot ID   B7LGG8
Organism   Escherichia coli strain 3R     
Function   repress competence development; post-transcriptional repression of CSP production (predicted from homology)   
Competence regulation

Genomic Context

Location: 3232186..3242845
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  G6Q95_RS15240 plsC 3232337..3233074 (-) 738 WP_000965712.1 1-acylglycerol-3-phosphate O-acyltransferase -
  G6Q95_RS15245 parC 3233307..3235564 (-) 2258 Protein_3010 DNA topoisomerase IV subunit A -
  G6Q95_RS15250 ygiV 3236109..3236591 (-) 483 WP_000183494.1 GyrI-like domain-containing protein -
  G6Q95_RS15255 ygiW 3236644..3237035 (-) 392 Protein_3012 OB fold stress tolerance protein YgiW -
  G6Q95_RS15260 ciaR 3237186..3237845 (+) 660 WP_001221502.1 quorum sensing response regulator transcription factor QseB Regulator
  G6Q95_RS15265 qseC 3237842..3239191 (+) 1350 Protein_3014 quorum sensing histidine kinase QseC -
  G6Q95_RS15270 ygiZ 3239237..3239569 (-) 333 WP_000912120.1 DUF2645 family protein -
  G6Q95_RS15275 mdaB 3239888..3240469 (+) 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
  G6Q95_RS15280 ygiN 3240500..3240814 (+) 315 WP_000958598.1 putative quinol monooxygenase -
  G6Q95_RS15285 parE 3240862..3242754 (-) 1893 WP_000195292.1 DNA topoisomerase IV subunit B -

Sequence

Protein


Download         Length: 219 a.a.        Molecular weight: 24745.66 Da        Isoelectric Point: 6.6543

>NTDB_id=373772 G6Q95_RS15260 WP_001221502.1 3237186..3237845(+) (ciaR) [Escherichia coli strain 3R]
MRILLIEDDMLIGDGIKTGLSKMGFSVDWFTQGRQGKEALYSAPYDAVILDLTLPGMDGRDILREWREKGQREPVLILTA
RDALEERVEGLRLGADDYLCKPFALIEVAARLEALMRRTNGQASNELRHGNVMLDPGKRIATLAGEPLTLKPKEFALLEL
LMRNAGRVLPRKLIEEKLYTWDEEVTSNAVEVHVHHLRRKLGSDFIRTVHGIGYTLGEK

Nucleotide


Download         Length: 660 bp        

>NTDB_id=373772 G6Q95_RS15260 WP_001221502.1 3237186..3237845(+) (ciaR) [Escherichia coli strain 3R]
ATGCGAATTTTACTGATAGAAGATGACATGCTGATTGGCGACGGCATCAAAACGGGCCTTAGTAAAATGGGTTTTAGCGT
CGACTGGTTTACACAAGGTCGTCAGGGAAAAGAGGCGCTTTATAGCGCGCCTTATGATGCGGTGATCCTGGATTTAACCT
TACCAGGCATGGATGGTCGCGATATTTTGCGCGAATGGCGAGAAAAAGGTCAGCGTGAGCCGGTACTGATCCTGACCGCG
CGCGATGCGCTGGAGGAACGTGTAGAAGGGCTGCGTCTGGGAGCTGACGATTATCTGTGTAAACCTTTTGCGTTGATAGA
AGTCGCCGCCAGGCTGGAAGCTCTGATGCGCCGAACCAACGGCCAGGCCAGCAACGAGCTGCGCCACGGTAACGTCATGC
TCGACCCCGGCAAACGTATCGCCACGCTGGCTGGCGAACCCTTAACACTGAAACCAAAAGAATTTGCCCTGCTGGAATTA
CTGATGCGTAACGCTGGTCGGGTACTGCCGCGCAAACTGATTGAAGAGAAACTGTATACCTGGGACGAAGAGGTCACCAG
TAATGCCGTTGAAGTGCATGTGCATCATCTGCGACGCAAACTCGGTAGTGATTTTATTCGTACCGTGCATGGTATTGGCT
ACACATTAGGTGAGAAATGA

Domains

Predicted by InterProScan.

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(145-216)

Response regulator receiver domain (Response_reg)

(3-112)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB B7LGG8

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaR Streptococcus pneumoniae Rx1

38.326

100

0.397
  ciaR Streptococcus pneumoniae D39

38.326

100

0.397
  ciaR Streptococcus pneumoniae R6

38.326

100

0.397
  ciaR Streptococcus pneumoniae TIGR4

38.326

100

0.397
  ciaR Streptococcus mutans UA159

35.874

100

0.365