Detailed information NTG0371868

Bioinformatically predicted

Overview

• Name: comX
• Type: Regulator
• Locus tag: ST64987_RS00845
• Genome accession: NZ_CP049053
• Coordinates: 143221..143718 (+)
• Length: 165 a.a.
• NCBI ID: WP_002949220.1
• Uniprot ID: Q5M6C4
• Organism: Streptococcus thermophilus strain ST64987
• Function: activation of late competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 138221..148718

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ST64987_RS00825 (ST64987_0117)	-	140146..140472 (+)	327	WP_014607875.1	M20/M25/M40 family metallo-hydrolase	-
ST64987_RS00830 (ST64987_0118)	-	140554..141744 (+)	1191	WP_024704158.1	cyclopropane-fatty-acyl-phospholipid synthase family protein	-
ST64987_RS00835 (ST64987_0119)	-	142003..142467 (-)	465	Protein_110	transposase family protein	-
ST64987_RS00840	-	142825..142929 (+)	105	Protein_111	IS200/IS605 family transposase	-
ST64987_RS00845 (ST64987_0120)	comX	143221..143718 (+)	498	WP_002949220.1	sigma factor	Regulator
ST64987_RS00850 (ST64987_0121)	-	143818..144660 (-)	843	WP_011225338.1	mechanosensitive ion channel family protein	-
ST64987_RS00855 (ST64987_0122)	tig	144801..146084 (+)	1284	WP_011680653.1	trigger factor	-
ST64987_RS00860 (ST64987_0123)	rpoE	146242..146817 (+)	576	WP_002949228.1	DNA-directed RNA polymerase subunit delta	-
ST64987_RS00865 (ST64987_0124)	-	147068..148672 (+)	1605	WP_113870453.1	CTP synthase	-

Sequence

Protein

• Length: 165 a.a.
• Molecular weight: 20160.12 Da
• Isoelectric Point: 5.2073

>NTDB_id=371868 ST64987_RS00845 WP_002949220.1 143221..143718(+) (comX) [Streptococcus thermophilus strain ST64987]
MEQEVFVKAYEKVRPIVLKAFRQYFIQLWDQADMEQEAMMTLYQLLKKFPDLEKDDDKLRRYFKTKFRNRLNDEVRRQES
VKRQANRQCYVEISDIAFCIPNKELDMVDRLAYDEQLNAFREQLSSEDSLKLDRLLGGECFRGRKKMIRELRFWMVDFDP
CNEED

Nucleotide

• Length: 498 bp

>NTDB_id=371868 ST64987_RS00845 WP_002949220.1 143221..143718(+) (comX) [Streptococcus thermophilus strain ST64987]
ATGGAACAAGAAGTTTTTGTTAAGGCATATGAAAAGGTAAGGCCAATTGTACTTAAGGCTTTTAGGCAATACTTTATTCA
GCTTTGGGATCAAGCTGACATGGAGCAAGAGGCGATGATGACTTTGTATCAGCTTTTAAAAAAGTTTCCTGATTTAGAGA
AAGATGATGATAAGTTACGTCGTTACTTTAAAACTAAGTTTAGGAATCGACTTAATGATGAAGTGAGGCGGCAGGAGTCA
GTAAAACGTCAAGCTAATAGACAGTGCTATGTTGAAATTTCAGATATTGCCTTTTGTATTCCCAATAAGGAGCTAGATAT
GGTTGATAGACTTGCTTATGATGAACAGCTTAATGCTTTTCGTGAGCAGTTATCATCGGAAGATTCTCTTAAGTTGGATC
GATTGTTGGGTGGTGAATGCTTTAGGGGAAGGAAAAAGATGATACGAGAGTTAAGATTTTGGATGGTTGACTTTGATCCA
TGTAATGAAGAAGACTGA

Domains

Predicted by InterProScan.

• Sigma-70 region 2 (Sigma70_r2) (10-79)

3D structure

• AlphaFold DB: Q5M6C4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comX	Streptococcus thermophilus LMD-9	100	100	1
comX	Streptococcus thermophilus LMG 18311	100	100	1
comX/sigX	Streptococcus salivarius strain HSISS4	89.091	100	0.891
comX	Streptococcus salivarius SK126	88.485	100	0.885
comX	Streptococcus sobrinus strain NIDR 6715-7	41.975	98.182	0.412
comR/comR2	Streptococcus gordonii str. Challis substr. CH1	42.581	93.939	0.4
comR/comR1	Streptococcus gordonii str. Challis substr. CH1	42.581	93.939	0.4
comX/sigX	Streptococcus infantarius subsp. infantarius ATCC BAA-102	41.667	94.545	0.394
comX/sigX	Streptococcus mutans UA159	41.026	94.545	0.388
comX/sigX/comX1/sigX1	Streptococcus pyogenes MGAS8232	42.667	90.909	0.388
comX/sigX/comX2/sigX2	Streptococcus pyogenes JRS4	42.667	90.909	0.388
comX/sigX/comX1/sigX1	Streptococcus pyogenes JRS4	42.667	90.909	0.388
comX/sigX/comX2/sigX2	Streptococcus pyogenes MGAS8232	42.667	90.909	0.388
comX/sigX/comX1/sigX1	Streptococcus pyogenes MGAS315	42	90.909	0.382
comX/sigX/comX2/sigX2	Streptococcus pyogenes MGAS315	42	90.909	0.382
comX/sigX	Streptococcus suis D9	40.523	92.727	0.376
comX/sigX	Streptococcus suis isolate S10	40.523	92.727	0.376
comX/sigX	Streptococcus suis P1/7	40.523	92.727	0.376