Detailed information NTG0371502

Bioinformatically predicted

Overview

• Name: covS
• Type: Regulator
• Locus tag: FLP15_RS10960
• Genome accession: NZ_CP041356
• Coordinates: 2293522..2295000 (-)
• Length: 492 a.a.
• NCBI ID: WP_142767147.1
• Uniprot ID: A0A514ZAH3
• Organism: Lactococcus protaetiae strain KACC 19320
• Function: repress the expression of comX (predicted from homology) Competence regulation

Genomic Context

Location: 2288522..2300000

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
FLP15_RS10945 (FLP15_10945)	murD	2288705..2290054 (-)	1350	WP_142767145.1	UDP-N-acetylmuramoyl-L-alanine--D-glutamate ligase	-
FLP15_RS10950 (FLP15_10950)	-	2290489..2290830 (-)	342	WP_142767146.1	P-II family nitrogen regulator	-
FLP15_RS10955 (FLP15_10955)	-	2291433..2292674 (-)	1242	WP_142767503.1	ammonium transporter	-
FLP15_RS10960 (FLP15_10960)	covS	2293522..2295000 (-)	1479	WP_142767147.1	HAMP domain-containing histidine kinase	Regulator
FLP15_RS10965 (FLP15_10965)	covR	2295009..2295701 (-)	693	WP_120772040.1	response regulator transcription factor	Regulator
FLP15_RS10970 (FLP15_10970)	-	2295856..2296386 (-)	531	WP_142767504.1	DUF177 domain-containing protein	-
FLP15_RS10975 (FLP15_10975)	-	2296924..2297169 (-)	246	WP_120772041.1	type B 50S ribosomal protein L31	-
FLP15_RS10980 (FLP15_10980)	-	2297332..2298411 (-)	1080	WP_142767505.1	carbamoyl phosphate synthase small subunit	-

Sequence

Protein

• Length: 492 a.a.
• Molecular weight: 56147.53 Da
• Isoelectric Point: 5.9465

>NTDB_id=371502 FLP15_RS10960 WP_142767147.1 2293522..2295000(-) (covS) [Lactococcus protaetiae strain KACC 19320]
MKKNKTPKEIENKNESSSKRSIMLRWAFANTVFCFITFTVFAVVIYQATITTFINEEKSVVLNSMTNIENVLSEAKEPLT
SENLHQYIEYTATIKPGNHSAEEQTLMSMIGSRKAFYIYDIDKHLLYSTHPRSFGFMNLKNNEIKQFDGKNPGFLVEREI
VSKSTGKVIGYLQAFYDLTSYHKVSNLLLISLLVLEVVALIVAQIIGYFMAHYFMRPLEKLHKGMQEVAEDPTGEFKPIE
IKTGDEIEELAHVYNEMMMKTNAYVEQQKRFVSDVSHELRTPLAVLDGHINLLNRWGKNDAEILDESLQASQFEISRMKK
MLEEMLALARLENVDLSSSELDCDVVKVCKHAVKNFALVRQEFEIELIQKVSDETKAKIYPNHYEQALSILLDNAAKYSP
DDRKSITITIAEDEDYVITKVSDKGIGISKEDIQHLFERFFRADKARNRDIGGTGLGLSIMARLAENYKGKIEVESELGV
GSTFILKIPKLD

Nucleotide

• Length: 1479 bp

>NTDB_id=371502 FLP15_RS10960 WP_142767147.1 2293522..2295000(-) (covS) [Lactococcus protaetiae strain KACC 19320]
ATGAAAAAAAATAAAACGCCCAAAGAAATAGAGAATAAAAATGAAAGCTCATCTAAAAGAAGTATCATGCTTAGATGGGC
TTTTGCTAATACAGTTTTTTGTTTTATCACCTTTACGGTATTTGCAGTTGTGATTTATCAGGCGACAATAACAACCTTTA
TCAATGAGGAGAAAAGCGTTGTATTAAATTCAATGACAAATATTGAAAATGTACTCTCCGAGGCAAAAGAGCCGTTAACT
TCGGAAAATTTACACCAATATATTGAGTATACAGCAACGATAAAGCCTGGTAACCATTCTGCTGAAGAGCAAACATTGAT
GAGTATGATTGGTAGTCGAAAAGCTTTTTATATCTACGATATTGATAAACACTTGCTTTATTCAACCCATCCTCGTTCAT
TTGGTTTCATGAATTTAAAAAATAATGAAATTAAGCAGTTTGATGGTAAAAATCCTGGATTTTTGGTTGAAAGAGAGATT
GTTTCTAAGTCAACGGGTAAGGTGATTGGATATTTACAGGCCTTTTATGATTTAACTTCTTATCATAAGGTAAGTAATCT
TCTATTGATTTCCCTCTTGGTTTTAGAAGTTGTAGCATTGATTGTAGCTCAGATTATTGGTTACTTCATGGCTCATTATT
TTATGAGACCATTAGAGAAGTTACATAAGGGAATGCAGGAAGTTGCTGAAGATCCGACAGGTGAATTTAAACCGATTGAA
ATTAAGACGGGTGATGAAATTGAGGAACTTGCCCATGTTTATAATGAGATGATGATGAAAACCAATGCTTACGTGGAGCA
ACAAAAACGCTTTGTTTCAGATGTTTCTCATGAGCTTAGGACACCGCTTGCTGTGTTGGATGGTCATATTAACCTGCTTA
ATCGTTGGGGAAAGAATGATGCTGAGATTTTGGATGAATCTTTGCAGGCAAGTCAGTTTGAAATTTCAAGAATGAAAAAG
ATGCTAGAGGAGATGCTTGCACTTGCAAGACTTGAAAATGTTGACTTATCTAGTAGTGAACTGGATTGTGACGTGGTAAA
AGTTTGTAAACATGCGGTGAAAAATTTTGCTTTGGTGCGTCAAGAATTTGAAATTGAGCTGATTCAAAAAGTGAGTGATG
AGACTAAGGCAAAAATTTATCCAAATCATTATGAGCAAGCTTTAAGTATTTTGTTAGATAATGCAGCGAAGTATTCACCT
GATGATAGAAAGTCAATTACAATCACGATTGCTGAGGATGAAGACTATGTGATTACGAAAGTCTCTGATAAGGGAATAGG
GATTTCTAAGGAAGATATTCAACACCTTTTTGAGCGCTTTTTCAGAGCAGATAAGGCAAGAAATAGAGATATTGGTGGAA
CAGGGCTCGGCTTGTCAATCATGGCACGTCTAGCGGAGAACTATAAAGGAAAAATTGAGGTAGAGTCTGAGCTTGGTGTT
GGCTCAACTTTCATATTAAAAATTCCGAAATTGGACTAA

Domains

Predicted by InterproScan.

• ArlS sensor domain (ArlS_N) (52-186)

• His Kinase A (phospho-acceptor) domain (HisKA) (268-333)

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (383-490)

• HAMP domain (HAMP) (209-260)

3D structure

• AlphaFold DB: A0A514ZAH3

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
covS	Lactococcus lactis subsp. lactis strain DGCC12653	70.455	98.374	0.693