Detailed information NTG0366352

Bioinformatically predicted

Overview

• Name: hexA
• Type: Machinery gene
• Locus tag: M594_RS09365
• Genome accession: NZ_CP047883
• Coordinates: 1945587..1948121 (-)
• Length: 844 a.a.
• NCBI ID: WP_173876648.1
• Uniprot ID: -
• Organism: Streptococcus mitis strain S022-V3-A4
• Function: DNA mismatch repair (predicted from homology) Homologous recombination

Genomic Context

Location: 1940587..1953121

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
M594_RS09335 (M594_09375)	-	1940640..1941314 (-)	675	WP_153210263.1	CPBP family intramembrane glutamic endopeptidase	-
M594_RS09340 (M594_09380)	-	1941311..1941874 (-)	564	WP_153210262.1	DNA-3-methyladenine glycosylase I	-
M594_RS09345 (M594_09385)	ruvA	1941884..1942477 (-)	594	WP_153210261.1	Holliday junction branch migration protein RuvA	Machinery gene
M594_RS09350 (M594_09390)	hexB	1942493..1944442 (-)	1950	WP_173876645.1	DNA mismatch repair endonuclease MutL	Machinery gene
M594_RS09355 (M594_09400)	-	1944650..1945090 (+)	441	WP_173876646.1	LytTR family DNA-binding domain-containing protein	-
M594_RS09360 (M594_09405)	-	1945087..1945545 (+)	459	WP_173876647.1	DUF3021 domain-containing protein	-
M594_RS09365 (M594_09410)	hexA	1945587..1948121 (-)	2535	WP_173876648.1	DNA mismatch repair protein MutS	Machinery gene
M594_RS09370 (M594_09415)	argR	1948172..1948618 (-)	447	WP_001231476.1	arginine repressor	-
M594_RS09375 (M594_09420)	argS	1948754..1950445 (+)	1692	WP_173876649.1	arginine--tRNA ligase	-
M594_RS09380 (M594_09425)	-	1950574..1950819 (+)	246	WP_049544515.1	hypothetical protein	-
M594_RS09385 (M594_09430)	nrdI	1950986..1951450 (-)	465	WP_173876650.1	class Ib ribonucleoside-diphosphate reductase assembly flavoprotein NrdI	-
M594_RS09390 (M594_09435)	-	1951528..1952061 (-)	534	WP_023946835.1	hypothetical protein	-

Sequence

Protein

• Length: 844 a.a.
• Molecular weight: 94627.05 Da
• Isoelectric Point: 4.8822

>NTDB_id=366352 M594_RS09365 WP_173876648.1 1945587..1948121(-) (hexA) [Streptococcus mitis strain S022-V3-A4]
MTTEKLSPGMQQYVDIKKQYPDAFLLFRMGDFYELFYEDAVNAAQILEISLTSRNKNADNPIPMAGVPYHSAQQYIDVLI
EQGYKVAIAEQMEDPKQAVGVVKREVVQVITPGTVVDSSKPDSQNNFLVAIDRAGNQFGLAYMDLVTGDFYVTGLLDFTL
VCGEIRNLKAREVVLGYDLSEEEEQILSRQMNLVLSYEKEGFEDLHLLDSRLAAVEQAASSKLLQYVHRTQMRELNHLKP
VIRYEIKDFLQMDYATKASLDLVENARSGKKQGSLFWLLDETKTAMGMRLLRSWIHRPLIDKERIVQRQEVVQVFLDHFF
ERSDLTDSLKGVYDIERLASRVSFGKTNPKELLQLATTLSSVPRIRAILEGMEQPALAYLIAQLDAIPELESLISAAIAP
EASHVITDGGIIRTGFDETLDKYRRVLREGTSWIAEIEAKEKENSGISTLKIEYNKKDGYYFHVTNSQLGNVPAHFFRKA
TLKNSERFGTEELARIEGDMLEAREKSANLEYEIFMRIREEVSKYIQRLQALAQGIATVDVLQSLAVVAETQHLIRPEFG
DDSQIDIQKGRHAVVEKVMGAQTYIPNTIQMGGDTSIQLITGPNMSGKSTYMRQLAMTAVMAQMGSYVPAENAYLPIFDA
IFTRIGAADDLVSGQSTFMVEMMEANNAISHATKDSLILFDELGRGTATYDGMALAQSIIEYIHEHIGAKTLFATHYHEL
TSLESSLEHLVNVHVATLEQGGQVTFLHKIEPGPADKSYGIHVAKIAGLPADLLARADKILTQLENQGTESPVLMRQTSD
VTEQISLFDTAEEHPILAELAKLDIYNMTPMQAMNVLVELKQKL

Nucleotide

• Length: 2535 bp

>NTDB_id=366352 M594_RS09365 WP_173876648.1 1945587..1948121(-) (hexA) [Streptococcus mitis strain S022-V3-A4]
ATGACGACAGAAAAGCTATCACCCGGCATGCAACAGTATGTGGATATTAAAAAGCAATATCCAGATGCTTTTTTGCTCTT
TCGGATGGGTGATTTTTATGAATTATTTTATGAGGATGCGGTCAATGCTGCGCAGATTCTGGAAATTTCCTTAACGAGTC
GCAACAAGAATGCCGACAATCCGATTCCTATGGCGGGTGTTCCCTATCATTCTGCCCAACAGTATATCGATGTCTTGATT
GAGCAGGGCTATAAGGTAGCCATTGCTGAACAGATGGAAGATCCTAAACAAGCAGTTGGGGTTGTGAAACGAGAGGTTGT
TCAGGTCATTACGCCAGGGACAGTGGTCGATAGCAGTAAGCCGGATAGTCAGAACAACTTCTTGGTTGCCATAGACCGTG
CTGGCAATCAATTTGGCCTAGCTTATATGGACCTGGTGACGGGTGACTTTTATGTGACAGGTCTTTTGGATTTCACGCTG
GTTTGTGGGGAAATCCGTAATCTCAAGGCGCGAGAAGTGGTGCTGGGCTATGACTTGTCTGAGGAAGAGGAACAAATCCT
TAGTCGTCAGATGAATCTGGTACTTTCCTATGAAAAAGAAGGCTTTGAAGACCTTCATTTACTGGATTCACGATTAGCAG
CTGTGGAGCAAGCGGCATCTAGTAAGTTGCTCCAGTATGTCCATCGAACCCAGATGAGGGAATTGAACCACCTCAAACCT
GTTATCCGCTATGAAATCAAGGATTTCTTGCAGATGGATTATGCGACCAAGGCTAGTCTGGATTTGGTTGAGAATGCTCG
GTCAGGCAAGAAGCAAGGCAGTCTTTTCTGGCTTTTGGATGAAACCAAAACAGCTATGGGTATGCGGCTCTTGCGGTCTT
GGATTCATCGCCCCTTGATTGATAAGGAACGAATTGTCCAACGCCAAGAAGTTGTGCAGGTCTTTCTCGACCATTTCTTT
GAGCGTAGTGATTTGACAGACAGTCTCAAGGGTGTTTATGACATTGAGCGCTTGGCTAGTCGTGTTTCTTTTGGTAAAAC
CAATCCCAAGGAACTCTTGCAGTTGGCGACTACCTTGTCTAGTGTGCCACGGATTCGTGCGATTTTAGAGGGGATGGAGC
AACCTGCTCTAGCCTATCTGATCGCACAACTAGATGCCATTCCAGAGTTGGAGAGCTTGATTAGTGCAGCGATTGCTCCT
GAAGCTTCTCATGTGATTACAGATGGGGGTATTATCCGGACTGGATTTGATGAGACCTTAGACAAGTACCGTCGCGTTCT
CAGAGAAGGGACTAGCTGGATTGCTGAAATTGAGGCCAAGGAGAAAGAAAACTCTGGTATTAGTACGCTTAAGATTGAGT
ACAATAAGAAGGATGGCTACTATTTCCATGTGACCAATTCGCAACTGGGGAATGTGCCAGCCCACTTTTTCCGCAAGGCG
ACGCTGAAAAACTCGGAACGTTTTGGAACCGAAGAATTAGCCCGTATCGAGGGAGATATGCTGGAGGCGCGTGAGAAGTC
AGCTAACCTAGAGTACGAAATTTTTATGCGTATTCGTGAAGAGGTCAGCAAGTACATCCAGCGTTTGCAGGCTCTAGCCC
AAGGAATTGCGACGGTTGATGTCTTACAGAGTCTGGCGGTTGTGGCCGAAACTCAGCATTTGATTCGACCTGAGTTTGGC
GATGACTCACAAATCGATATCCAGAAAGGGCGCCATGCTGTCGTTGAAAAGGTCATGGGAGCTCAGACCTATATTCCAAA
TACCATTCAAATGGGAGGGGATACTAGTATCCAGTTGATTACAGGGCCTAACATGAGTGGGAAGTCGACCTATATGCGTC
AGCTGGCCATGACAGCGGTGATGGCTCAGATGGGTTCTTACGTACCAGCAGAGAATGCTTATTTACCGATTTTTGATGCT
ATCTTTACCCGTATCGGAGCAGCAGATGACTTGGTTTCAGGTCAGTCCACCTTTATGGTGGAGATGATGGAGGCCAATAA
TGCCATTTCGCATGCGACCAAGGACTCTCTCATTCTCTTTGATGAATTGGGACGAGGAACTGCAACTTATGACGGAATGG
CTCTTGCCCAGTCCATCATCGAATATATCCATGAGCATATCGGAGCCAAGACCCTCTTTGCGACCCACTACCATGAGTTG
ACCAGTCTGGAGTCTAGCTTGGAACACTTGGTCAATGTTCACGTGGCAACTTTGGAGCAAGGTGGGCAGGTCACCTTCCT
TCACAAGATTGAACCAGGACCAGCTGATAAATCCTACGGTATCCATGTTGCCAAGATTGCTGGTTTGCCAGCAGACCTTC
TAGCAAGGGCGGATAAGATTTTGACTCAGTTAGAGAATCAAGGTACAGAAAGTCCAGTTCTTATGAGGCAAACAAGCGAC
GTCACGGAACAGATTTCACTATTTGATACGGCAGAAGAGCATCCTATCCTAGCAGAATTAGCTAAATTGGACATTTACAA
CATGACACCCATGCAGGCTATGAATGTCTTGGTCGAGTTGAAACAAAAACTATAA

Domains

Predicted by InterProScan.

• MutS family domain IV (MutS_IV) (415-505)

• MutS domain I (MutS_I) (8-118)

• MutS domain II (MutS_II) (126-239)

• MutS domain V (MutS_V) (599-785)

• MutS domain III (MutS_III) (256-546)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
hexA	Streptococcus pneumoniae R6	96.327	100	0.963
mutS	Pseudomonas stutzeri strain ATCC 17587	36.3	100	0.367