Detailed information    

insolico Bioinformatically predicted

Overview

Name   comFA/cflA   Type   Machinery gene
Locus tag   SMUNN2025_RS07560 Genome accession   NC_013928
Coordinates   1554896..1556197 (-) Length   433 a.a.
NCBI ID   WP_002277412.1    Uniprot ID   -
Organism   Streptococcus mutans NN2025     
Function   ssDNA transport into the cell (predicted from homology)   
DNA binding and uptake

Genomic Context

Location: 1549896..1561197
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  SMUNN2025_RS07535 (SmuNN2025_1469) - 1549954..1550589 (+) 636 WP_002271877.1 hypothetical protein -
  SMUNN2025_RS07540 (SmuNN2025_1470) - 1550669..1552369 (-) 1701 WP_002287673.1 zinc ribbon domain-containing protein -
  SMUNN2025_RS07545 (SmuNN2025_1471) - 1552389..1553483 (-) 1095 WP_002268894.1 hypothetical protein -
  SMUNN2025_RS07550 (SmuNN2025_1472) hpf 1553607..1554155 (-) 549 WP_002263024.1 ribosome hibernation-promoting factor, HPF/YfiA family -
  SMUNN2025_RS07555 (SmuNN2025_1473) - 1554234..1554899 (-) 666 WP_012997900.1 ComF family protein -
  SMUNN2025_RS07560 (SmuNN2025_1474) comFA/cflA 1554896..1556197 (-) 1302 WP_002277412.1 DEAD/DEAH box helicase Machinery gene
  SMUNN2025_RS07565 (SmuNN2025_1475) - 1556270..1556899 (+) 630 WP_002267042.1 YigZ family protein -
  SMUNN2025_RS07570 (SmuNN2025_1476) cysK 1556990..1557916 (+) 927 WP_002277411.1 cysteine synthase A -
  SMUNN2025_RS07575 (SmuNN2025_1477) - 1558252..1559343 (-) 1092 WP_002263029.1 glycerol dehydrogenase -
  SMUNN2025_RS07580 (SmuNN2025_1478) - 1559381..1560049 (-) 669 WP_002263030.1 fructose-6-phosphate aldolase -

Sequence

Protein


Download         Length: 433 a.a.        Molecular weight: 49510.64 Da        Isoelectric Point: 9.9111

>NTDB_id=36605 SMUNN2025_RS07560 WP_002277412.1 1554896..1556197(-) (comFA/cflA) [Streptococcus mutans NN2025]
MENLENYYGRLLTENQMNSDLKKQAKILPAMIKKPHYFICNRCGSQNNLGNALPDGSIYCRACLVFGRLTNRDSLYYFEQ
KPFPRGQVLRWQGQLTPFQQEVSRGLKKSVCHKENMLIHAVTGAGKTEMIYETLASILNQGGAVALASPRIDVCIELYKR
LSRDFSCPISLLHGESEAYERSPLVIATTHQLLKFYRAFDLLIIDEVDAFPFVDNKMLYYAVDHCLKSDGVKVFLTATST
DQLDKQVKQGKLKKLHLARRFHANPLVVPKPIWLNLSLERLQRDKLPHSFLQQIRIQRQTQFPLLIFFPNIEDGLTFAKS
LQTYLPNEKIDFVSSLTTDRLEKVENFRKGNTQILVSTTILERGVTFPCVDVFVMMSNHYLFTKSSLVQIAGRVGRSADR
PDGKLLFFHNGMNRAMKKAIMEIKTMNKKGGFA

Nucleotide


Download         Length: 1302 bp        

>NTDB_id=36605 SMUNN2025_RS07560 WP_002277412.1 1554896..1556197(-) (comFA/cflA) [Streptococcus mutans NN2025]
ATGGAGAATTTAGAGAATTATTATGGCCGCCTCTTGACCGAGAATCAAATGAACAGTGATTTGAAAAAGCAAGCTAAAAT
CTTGCCAGCTATGATAAAAAAACCGCATTACTTTATCTGCAATCGTTGCGGCAGTCAGAACAATCTTGGTAATGCTTTGC
CGGATGGATCTATCTACTGTCGAGCTTGTCTTGTCTTTGGACGTCTTACTAACAGGGACAGTCTTTATTATTTTGAGCAA
AAGCCTTTTCCAAGGGGTCAGGTCTTAAGGTGGCAAGGGCAATTAACCCCTTTTCAGCAGGAAGTTTCCCGTGGTTTAAA
AAAGAGTGTTTGCCATAAGGAAAATATGCTTATTCATGCTGTAACAGGTGCAGGCAAAACGGAGATGATTTATGAAACTC
TGGCCAGCATTCTCAATCAAGGGGGTGCGGTTGCACTTGCTAGTCCTCGCATTGATGTCTGCATAGAACTGTATAAACGT
TTAAGTCGTGACTTTTCTTGTCCTATCAGTCTTTTGCATGGAGAGTCAGAAGCTTATGAACGCAGTCCATTAGTGATTGC
AACCACGCATCAACTTTTGAAATTTTACCGAGCTTTTGATTTGTTAATTATTGATGAAGTAGATGCCTTTCCTTTTGTTG
ACAATAAGATGCTCTATTATGCTGTAGATCATTGTCTGAAATCAGATGGTGTCAAAGTATTTTTGACTGCAACTTCGACT
GACCAATTAGACAAACAGGTTAAGCAAGGGAAGCTAAAAAAACTGCATTTAGCCAGACGATTTCATGCCAATCCCTTAGT
TGTTCCCAAGCCAATTTGGTTGAATTTATCTCTTGAAAGATTACAAAGAGATAAATTACCGCACTCTTTTTTACAGCAGA
TAAGAATTCAAAGGCAGACTCAATTCCCTCTTTTGATCTTTTTTCCGAATATTGAAGATGGTTTAACCTTTGCTAAATCA
CTGCAAACTTATCTTCCAAATGAGAAAATTGATTTTGTTTCCAGCTTGACAACAGATCGTTTAGAAAAAGTCGAAAATTT
TAGAAAAGGAAACACACAAATTTTGGTTTCAACAACGATTTTAGAGAGGGGAGTCACTTTTCCTTGTGTAGATGTTTTTG
TCATGATGAGCAACCATTATCTGTTCACCAAAAGTTCTCTGGTACAAATTGCTGGTCGTGTGGGACGCTCTGCCGATAGA
CCAGATGGAAAATTACTTTTCTTTCATAATGGAATGAACAGAGCCATGAAAAAGGCCATTATGGAAATCAAGACTATGAA
CAAAAAAGGAGGTTTTGCATGA

Domains

Predicted by InterproScan.

Helicase conserved C-terminal domain (Helicase_C)

(296-397)

Type III restriction enzyme, res subunit (ResIII)

(94-194)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comFA/cflA Streptococcus pneumoniae Rx1

59.485

98.614

0.587
  comFA/cflA Streptococcus pneumoniae D39

59.485

98.614

0.587
  comFA/cflA Streptococcus pneumoniae R6

59.485

98.614

0.587
  comFA/cflA Streptococcus pneumoniae TIGR4

59.485

98.614

0.587
  comFA/cflA Streptococcus mitis NCTC 12261

58.782

98.614

0.58
  comFA/cflA Streptococcus mitis SK321

58.314

98.614

0.575
  comFA Lactococcus lactis subsp. cremoris KW2

51.777

90.993

0.471
  comFA Latilactobacillus sakei subsp. sakei 23K

38.732

98.383

0.381

Multiple sequence alignment