Detailed information NTG0354548

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: SaO322_RS10105
• Genome accession: NZ_CP038460
• Coordinates: 1959973..1961016 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain B119
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1954973..1966016

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
SaO322_RS10075 (SaO322_01855)	-	1955394..1956650 (-)	1257	WP_001793428.1	aminopeptidase	-
SaO322_RS10080 (SaO322_01856)	-	1956653..1956853 (-)	201	WP_000180462.1	DUF1128 family protein	-
SaO322_RS10085 (SaO322_01857)	-	1957000..1957464 (+)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
SaO322_RS10090 (SaO322_01858)	-	1957471..1957746 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
SaO322_RS10095 (SaO322_01859)	-	1958024..1959241 (+)	1218	WP_000037094.1	YihY/virulence factor BrkB family protein	-
SaO322_RS10100 (SaO322_01860)	vraR	1959354..1959983 (-)	630	WP_000153530.1	two-component system response regulator VraR	Regulator
SaO322_RS10105 (SaO322_01861)	vraS	1959973..1961016 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
SaO322_RS10110 (SaO322_01862)	liaF	1961013..1961714 (-)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
SaO322_RS10115 (SaO322_01863)	-	1961729..1962115 (-)	387	WP_001110180.1	hypothetical protein	-
SaO322_RS10120 (SaO322_01864)	map	1962332..1963090 (-)	759	WP_000636142.1	type I methionyl aminopeptidase	-
SaO322_RS10125 (SaO322_01865)	-	1963662..1964648 (+)	987	WP_000999713.1	aromatic acid exporter family protein	-
SaO322_RS10130 (SaO322_01866)	-	1964837..1965250 (-)	414	WP_118848178.1	hypothetical protein	-
SaO322_RS10135	-	1965279..1965391 (-)	113	Protein_1887	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=354548 SaO322_RS10105 WP_001017131.1 1959973..1961016(-) (vraS) [Staphylococcus aureus strain B119]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=354548 SaO322_RS10105 WP_001017131.1 1959973..1961016(-) (vraS) [Staphylococcus aureus strain B119]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATTTTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1