Detailed information    

insolico Bioinformatically predicted

Overview

Name   comGA/cglA/cilD   Type   Machinery gene
Locus tag   ES298_RS10110 Genome accession   NZ_CP038253
Coordinates   1947934..1948875 (-) Length   313 a.a.
NCBI ID   WP_000249536.1    Uniprot ID   -
Organism   Streptococcus pneumoniae strain TVO_1901929     
Function   dsDNA binding to the cell surface; assembly of the pseudopilus (predicted from homology)   
DNA binding and uptake

Genomic Context

Location: 1942934..1953875
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  ES298_RS10070 (ES298_10610) comYH 1943426..1944379 (-) 954 WP_000345126.1 class I SAM-dependent methyltransferase Machinery gene
  ES298_RS10075 (ES298_10615) - 1944440..1945032 (-) 593 Protein_1983 class I SAM-dependent methyltransferase -
  ES298_RS10080 (ES298_10620) comGG/cglG 1945135..1945581 (-) 447 WP_001809944.1 competence type IV pilus minor pilin ComGG Machinery gene
  ES298_RS10085 (ES298_10625) comGF/cglF 1945559..1946020 (-) 462 WP_000250531.1 competence type IV pilus minor pilin ComGF Machinery gene
  ES298_RS10090 (ES298_10630) comGE/cglE 1945983..1946285 (-) 303 WP_000413382.1 competence type IV pilus minor pilin ComGE Machinery gene
  ES298_RS10095 (ES298_10635) comGD/cglD 1946248..1946682 (-) 435 WP_033606693.1 competence type IV pilus minor pilin ComGD Machinery gene
  ES298_RS10100 (ES298_10640) comGC/cglC 1946645..1946968 (-) 324 WP_000738628.1 comG operon protein ComGC Machinery gene
  ES298_RS10105 (ES298_10645) comGB/cglB 1946970..1947986 (-) 1017 WP_078130737.1 competence type IV pilus assembly protein ComGB Machinery gene
  ES298_RS10110 (ES298_10650) comGA/cglA/cilD 1947934..1948875 (-) 942 WP_000249536.1 competence type IV pilus ATPase ComGA Machinery gene
  ES298_RS10115 (ES298_10655) - 1948951..1949316 (-) 366 WP_000286415.1 DUF1033 family protein -
  ES298_RS10120 (ES298_10660) - 1949467..1950525 (-) 1059 WP_000649468.1 zinc-dependent alcohol dehydrogenase family protein -
  ES298_RS10125 (ES298_10665) nagA 1950688..1951839 (-) 1152 WP_001134457.1 N-acetylglucosamine-6-phosphate deacetylase -
  ES298_RS10130 (ES298_10670) - 1951992..1953809 (-) 1818 WP_001220842.1 acyltransferase family protein -

Sequence

Protein


Download         Length: 313 a.a.        Molecular weight: 35493.37 Da        Isoelectric Point: 5.8161

>NTDB_id=352740 ES298_RS10110 WP_000249536.1 1947934..1948875(-) (comGA/cglA/cilD) [Streptococcus pneumoniae strain TVO_1901929]
MVQEIAQEIIRSAREKGTQDIYFVPKLDAYELHMRVGDERCKIGSYDFEKFAAVISHFKFVAGMNVGEKRRSQLGSCDYA
YDQKMASLRLSTVGDYRGHESLVIRLLHDEEQDLHFWFQDIEELGKQYRQRGLYLFAGPVGSGKTTLMHELSKSLFKGQQ
VMSIEDPVEIKQDDMLQLQLNEAIGLTYGNLIKLSLRHRPDLLIIGEIRDSETARAVVRASLTGATVFSTIHAKSIRGVY
ERLLELGVSEEELAVVLQGVCYQRLIGGGGIVDFASRDYQEHQAAKWNEQIDQLLKDGHITSLQAETEKISYS

Nucleotide


Download         Length: 942 bp        

>NTDB_id=352740 ES298_RS10110 WP_000249536.1 1947934..1948875(-) (comGA/cglA/cilD) [Streptococcus pneumoniae strain TVO_1901929]
ATGGTTCAAGAAATTGCACAAGAAATCATTCGTTCAGCTCGGGAAAAAGGGACGCAGGATATTTATTTTGTCCCTAAGTT
AGACGCCTATGAGCTTCATATGAGGGTAGGAGACGAGCGCTGTAAAATTGGTAGCTATGATTTTGAAAAGTTTGCAGCCG
TTATCAGTCACTTTAAGTTTGTGGCGGGTATGAATGTGGGAGAAAAAAGACGTAGTCAACTGGGTTCCTGTGATTATGCC
TATGACCAGAAGATGGCGTCTCTACGTTTATCTACTGTAGGCGATTATCGGGGGCATGAGAGTTTGGTTATCCGTTTGTT
GCACGATGAGGAACAGGACTTGCATTTTTGGTTTCAGGATATTGAAGAATTAGGCAAGCAGTACAGGCAACGGGGACTCT
ATCTTTTTGCTGGTCCGGTTGGGAGTGGTAAGACGACCTTGATGCATGAATTGTCCAAGTCACTCTTTAAAGGACAGCAA
GTTATGTCCATCGAAGATCCTGTCGAAATCAAGCAGGACGACATGCTTCAGTTGCAGTTGAACGAAGCAATCGGCCTAAC
CTATGGAAATCTAATCAAACTTTCCTTGCGTCATCGACCAGATCTCTTGATTATCGGAGAAATTCGTGACAGCGAGACGG
CGCGTGCAGTGGTCAGAGCTAGTTTGACAGGTGCGACAGTCTTTTCAACCATTCACGCCAAGAGTATCCGAGGTGTTTAT
GAGCGTCTGCTGGAGTTGGGTGTGAGTGAAGAAGAATTGGCAGTTGTTCTGCAAGGAGTCTGCTACCAGAGATTAATCGG
GGGAGGAGGAATCGTTGACTTTGCAAGCAGAGATTATCAAGAACACCAAGCAGCCAAGTGGAATGAGCAAATTGACCAGC
TTCTTAAAGATGGACATATCACAAGTCTTCAGGCTGAGACGGAAAAAATTAGCTACAGCTAA

Domains

Predicted by InterproScan.

Type II/IV secretion system protein (T2SSE)

(9-266)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comGA/cglA/cilD Streptococcus pneumoniae Rx1

98.722

100

0.987
  comGA/cglA/cilD Streptococcus pneumoniae D39

98.722

100

0.987
  comGA/cglA/cilD Streptococcus pneumoniae R6

98.722

100

0.987
  comGA/cglA/cilD Streptococcus pneumoniae TIGR4

98.722

100

0.987
  comGA/cglA/cilD Streptococcus mitis NCTC 12261

95.847

100

0.958
  comYA Streptococcus gordonii str. Challis substr. CH1

78.065

99.042

0.773
  comYA Streptococcus mutans UA159

65.916

99.361

0.655
  comYA Streptococcus mutans UA140

65.916

99.361

0.655
  comGA/cglA Streptococcus sobrinus strain NIDR 6715-7

62.903

99.042

0.623
  comGA Lactococcus lactis subsp. cremoris KW2

55.128

99.681

0.55
  comGA Latilactobacillus sakei subsp. sakei 23K

41.544

86.901

0.361

Multiple sequence alignment