Detailed information    

insolico Bioinformatically predicted

Overview

Name   crp   Type   Regulator
Locus tag   GC226_RS21760 Genome accession   NZ_CP045209
Coordinates   4457409..4458041 (+) Length   210 a.a.
NCBI ID   WP_000242755.1    Uniprot ID   A0A1C4FZU4
Organism   Escherichia coli strain 4     
Function   promote expression of competence genes (predicted from homology)   
Competence regulation

Genomic Context

Location: 4452409..4463041
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  GC226_RS21735 (GC226_21915) yheS 4452578..4454491 (+) 1914 WP_089589404.1 ABC transporter ATP-binding protein -
  GC226_RS21740 (GC226_21920) yheT 4454491..4455513 (+) 1023 WP_000057405.1 hydrolase -
  GC226_RS21745 (GC226_21925) yheU 4455507..4455725 (+) 219 WP_000907085.1 YheU family protein -
  GC226_RS21750 (GC226_21930) prkB 4455779..4456648 (+) 870 WP_001274680.1 phosphoribulokinase -
  GC226_RS21755 (GC226_21935) yhfA 4456703..4457107 (-) 405 WP_001148908.1 OsmC family protein -
  GC226_RS21760 (GC226_21940) crp 4457409..4458041 (+) 633 WP_000242755.1 cAMP-activated global transcriptional regulator CRP Regulator
  GC226_RS21765 (GC226_21945) yhfK 4458092..4460182 (+) 2091 WP_001295162.1 YccS/YhfK family putative transporter -
  GC226_RS21770 (GC226_21950) argD 4460249..4461469 (-) 1221 WP_000963785.1 bifunctional acetylornithine/succinyldiaminopimelate transaminase -
  GC226_RS21775 (GC226_21955) pabA 4461555..4462118 (-) 564 WP_000601847.1 aminodeoxychorismate synthase component 2 -
  GC226_RS21780 (GC226_21960) fic 4462150..4462752 (-) 603 WP_001280624.1 putative adenosine monophosphate-protein transferase Fic -
  GC226_RS21785 (GC226_21965) yhfG 4462742..4462909 (-) 168 WP_000736860.1 YhfG family protein -

Sequence

Protein


Download         Length: 210 a.a.        Molecular weight: 23640.43 Da        Isoelectric Point: 8.2710

>NTDB_id=343963 GC226_RS21760 WP_000242755.1 4457409..4458041(+) (crp) [Escherichia coli strain 4]
MVLGKPQTDPTLEWFLSHCHIHKYPSKSTLIHQGEKAETLYYIVKGSVAVLIKDEEGKEMILSYLNQGDFIGELGLFEEG
QERSAWVRAKTACEVAEISYKKFRQLIQVNPDILMRLSAQMARRLQVTSEKVGNLAFLDVTGRIAQTLLNLAKQPDAMTH
PDGMQIKITRQEIGQIVGCSRETVGRILKMLEDQNLISAHGKTIVVYGTR

Nucleotide


Download         Length: 633 bp        

>NTDB_id=343963 GC226_RS21760 WP_000242755.1 4457409..4458041(+) (crp) [Escherichia coli strain 4]
ATGGTGCTTGGCAAACCGCAAACAGACCCGACTCTCGAATGGTTCTTGTCTCATTGCCACATTCATAAGTACCCATCCAA
GAGCACGCTTATTCACCAGGGTGAAAAAGCGGAAACGCTGTACTACATCGTTAAAGGCTCTGTGGCAGTGCTGATCAAAG
ACGAAGAGGGTAAAGAAATGATCCTCTCCTATCTGAATCAGGGTGATTTTATTGGCGAACTGGGCCTGTTTGAAGAGGGC
CAGGAACGTAGCGCATGGGTACGTGCGAAAACCGCCTGTGAAGTGGCTGAAATTTCGTACAAAAAATTTCGCCAATTGAT
TCAGGTAAACCCGGACATTCTGATGCGTCTGTCTGCACAGATGGCGCGTCGTCTGCAAGTCACTTCAGAGAAAGTGGGCA
ACCTGGCGTTCCTCGACGTGACGGGCCGCATTGCACAGACTCTGCTGAACCTGGCAAAACAACCAGATGCTATGACTCAC
CCGGACGGTATGCAAATCAAAATTACCCGTCAGGAAATCGGTCAGATTGTCGGCTGTTCTCGTGAAACCGTGGGACGCAT
TCTGAAGATGCTGGAAGATCAGAACCTGATCTCCGCACACGGTAAAACCATCGTCGTTTACGGCACTCGTTAA

Domains

Predicted by InterProScan.

Cyclic nucleotide-binding domain (cNMP_binding)

(23-109)

Crp-like helix-turn-helix domain (HTH_Crp_2)

(142-206)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A1C4FZU4

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  crp Vibrio cholerae strain A1552

95.714

100

0.957
  crp Haemophilus influenzae Rd KW20

77.941

97.143

0.757
  crp Acinetobacter baumannii D1279779

47.343

98.571

0.467

Multiple sequence alignment