Detailed information NTG0343076

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: EU512_RS05120
• Genome accession: NZ_CP035541
• Coordinates: 1042205..1043251 (+)
• Length: 348 a.a.
• NCBI ID: WP_011275375.1
• Uniprot ID: A0A2A1K920
• Organism: Staphylococcus haemolyticus strain PK-01
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1037205..1048251

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
EU512_RS05095 (EU512_05100)	map	1038065..1038817 (+)	753	WP_011275369.1	type I methionyl aminopeptidase	-
EU512_RS05100 (EU512_05105)	-	1038942..1039799 (-)	858	WP_011275370.1	SDR family oxidoreductase	-
EU512_RS05105 (EU512_05110)	-	1039871..1040883 (-)	1013	Protein_1024	HoxN/HupN/NixA family nickel/cobalt transporter	-
EU512_RS05110 (EU512_05115)	-	1041096..1041482 (+)	387	WP_011275373.1	hypothetical protein	-
EU512_RS05115 (EU512_05120)	liaF	1041507..1042208 (+)	702	WP_011275374.1	cell wall-active antibiotics response protein LiaF	-
EU512_RS05120 (EU512_05125)	vraS	1042205..1043251 (+)	1047	WP_011275375.1	sensor histidine kinase	Regulator
EU512_RS05125 (EU512_05130)	vraR	1043241..1043870 (+)	630	WP_011275376.1	two-component system response regulator VraR	Regulator
EU512_RS05130 (EU512_05135)	-	1043934..1045145 (-)	1212	WP_011275377.1	YihY/virulence factor BrkB family protein	-
EU512_RS05135 (EU512_05140)	-	1045342..1045626 (-)	285	WP_011275378.1	YtxH domain-containing protein	-
EU512_RS05140 (EU512_05145)	-	1045632..1046096 (-)	465	WP_011275379.1	low molecular weight protein-tyrosine-phosphatase	-
EU512_RS05145 (EU512_05150)	-	1046238..1046447 (+)	210	WP_011275380.1	DUF1128 domain-containing protein	-
EU512_RS05150 (EU512_05155)	-	1046461..1047708 (+)	1248	WP_011275381.1	aminopeptidase	-

Sequence

Protein

• Length: 348 a.a.
• Molecular weight: 40179.58 Da
• Isoelectric Point: 6.0550

>NTDB_id=343076 EU512_RS05120 WP_011275375.1 1042205..1043251(+) (vraS) [Staphylococcus haemolyticus strain PK-01]
MNHYLRAIGSMLILVYSMLTAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLVIILLCIIVGSILAYKINQQNQWIKS
QIEHAIEGETVGINDQNIELYNETIDLYQTLVPLNQELHRLRMKTQNLTNENYNMNDVKVKKIIENERQRLARELHDSVS
QQLFAASMMLSAIKETKLEAPLDQQIPVLEKMVQESQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVIHDI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNQQDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNREDDNNDD

Nucleotide

• Length: 1047 bp

>NTDB_id=343076 EU512_RS05120 WP_011275375.1 1042205..1043251(+) (vraS) [Staphylococcus haemolyticus strain PK-01]
ATGAACCACTACTTAAGAGCTATCGGTTCAATGCTTATACTAGTTTATAGCATGTTAACCGCGTTCTTATTTATAGATAA
AGTATTTGTTAATATTATCTATTTCCAAGGTATGTTTTATACTCAAATTTTTGGGATACCTGTTTTTCTATTTTTAAATT
TAGTCATCATTTTACTTTGTATTATAGTAGGTTCAATTCTCGCATATAAAATTAATCAACAAAATCAGTGGATTAAGTCG
CAAATTGAGCATGCCATTGAAGGAGAAACAGTAGGTATCAATGATCAAAACATTGAGCTCTATAACGAAACCATAGATCT
TTATCAAACATTAGTTCCTCTAAATCAAGAGTTGCACCGTTTACGAATGAAAACGCAAAACTTAACTAATGAAAATTACA
ATATGAATGATGTCAAAGTTAAGAAAATCATTGAGAATGAACGACAGAGATTAGCTCGCGAGTTACATGACTCTGTAAGT
CAACAACTTTTTGCAGCAAGTATGATGTTATCTGCTATAAAAGAAACAAAATTAGAGGCACCGCTTGATCAACAAATACC
AGTTTTAGAGAAAATGGTTCAGGAATCTCAACTTGAAATGCGCGCATTATTACTTCATTTGAGACCTTTAGGACTAAAAG
ATAAATCACTAGGTGAAGGTATCAAAGATTTAGTTATTGATTTGCAAAAGAAAGTGCCTATGAAAGTCATACACGATATT
CAAGATTTCAAGGTTCCTAAAGGTATAGAAGATCATTTATTTAGAATTACACAAGAGGCTATATCAAATACGTTAAGACA
TTCTAATGGAACTAAAGTCACAGTGGAATTATTTAACCAACAAGATTATCTATTACTTCGAATTCAAGATAATGGTAAGG
GATTCAATGTTGACGAGAAATTAGAACAAAGTTATGGATTAAAAAATATGAGAGAACGCGCATTAGAAATTGGTGCGACA
TTCCATATTGTTTCGTTACCGGATTCTGGAACGAGAATAGAAGTTAAAGCACCATTAAATAGGGAGGATGATAATAATGA
CGATTAA

Domains

Predicted by InterproScan.

• Histidine kinase (HisKA_3) (147-210)

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

3D structure

• AlphaFold DB: A0A2A1K920

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	91.643	99.713	0.914