Detailed information NTG0342269

Bioinformatically predicted

Overview

• Name: comR
• Type: Regulator
• Locus tag: ETT48_RS00330
• Genome accession: NZ_CP035451
• Coordinates: 53153..54064 (+)
• Length: 303 a.a.
• NCBI ID: WP_014635220.1
• Uniprot ID: -
• Organism: Streptococcus pyogenes strain emm230
• Function: activate transcription of comX (predicted from homology) Competence regulation

Genomic Context

Location: 48153..59064

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ETT48_RS00310 (ETT48_00310)	purE	48459..48950 (+)	492	WP_002987716.1	5-(carboxyamino)imidazole ribonucleotide mutase	-
ETT48_RS00315 (ETT48_00315)	purK	48937..50010 (+)	1074	WP_002987718.1	5-(carboxyamino)imidazole ribonucleotide synthase	-
ETT48_RS00320 (ETT48_00320)	-	50031..51455 (+)	1425	WP_227878032.1	hypothetical protein	-
ETT48_RS00325 (ETT48_00325)	purB	51730..53022 (+)	1293	WP_002986683.1	adenylosuccinate lyase	-
ETT48_RS00330 (ETT48_00330)	comR	53153..54064 (+)	912	WP_014635220.1	XRE family transcriptional regulator	Regulator
ETT48_RS09415	comS	54155..54253 (+)	99	WP_020833188.1	quorum-sensing system DWW-type pheromone	Regulator
ETT48_RS00335 (ETT48_00335)	ruvB	54284..55282 (+)	999	WP_002986679.1	Holliday junction branch migration DNA helicase RuvB	-
ETT48_RS00340 (ETT48_00340)	-	55420..55857 (+)	438	WP_002994668.1	low molecular weight protein-tyrosine-phosphatase	-
ETT48_RS00345 (ETT48_00345)	-	55880..56281 (+)	402	WP_012560369.1	MORN repeat-containing protein	-
ETT48_RS00350 (ETT48_00350)	-	56278..58053 (+)	1776	WP_002994672.1	acyltransferase family protein	-

Sequence

Protein

• Length: 303 a.a.
• Molecular weight: 35925.63 Da
• Isoelectric Point: 4.9349

>NTDB_id=342269 ETT48_RS00330 WP_014635220.1 53153..54064(+) (comR) [Streptococcus pyogenes strain emm230]
MLEHFGGKVKVLRLEKRISREDLCGDESELSVRQLARIELGQSIPSLSKVIFIAKALNVSVGYLTDGADLELPKRYKELK
YLILRTPTYMDDGKLQVREEQFDEIFEDYYDKLPEEEKVAVDIIQAKFEVYQTGDINFGYSILKEFLPQLKRKSIYNLNE
LLLIDLYLIILVVSHFSDDIFDVQFYEEITESMLKQHNNLPLEDLFLLNNILLSCADTYIRLKMFGRLKETLQLSHFIMS
TIQDFQKMPMYCMYEWKLSIFYLKDINRARNYFEQSILFTQMTGDTYLVQKLRGEWNKDIHYI

Nucleotide

• Length: 912 bp

>NTDB_id=342269 ETT48_RS00330 WP_014635220.1 53153..54064(+) (comR) [Streptococcus pyogenes strain emm230]
ATGTTAGAACATTTTGGTGGAAAAGTAAAAGTGTTAAGACTTGAAAAGAGGATTAGTCGCGAGGACTTGTGTGGGGATGA
GTCTGAACTTTCTGTTCGTCAATTAGCACGGATAGAACTAGGTCAATCCATACCAAGTTTAAGTAAGGTTATTTTTATTG
CAAAAGCCTTAAACGTTAGTGTCGGTTACTTAACTGATGGTGCTGATTTAGAACTACCTAAGCGTTACAAAGAATTAAAA
TACCTTATCTTAAGGACACCAACTTACATGGATGATGGAAAATTACAAGTACGAGAAGAGCAGTTTGATGAAATTTTTGA
GGATTATTATGATAAATTACCAGAGGAAGAGAAAGTTGCTGTTGATATTATCCAAGCAAAATTTGAAGTTTATCAAACCG
GAGATATTAATTTCGGATATAGTATTTTAAAAGAATTTCTACCACAGCTAAAAAGAAAATCTATCTATAATTTAAATGAA
TTATTACTTATAGATTTGTATTTGATTATTCTGGTAGTTTCTCATTTTTCAGATGATATATTTGATGTACAGTTTTATGA
AGAAATAACAGAGAGCATGTTAAAACAACACAATAATTTACCATTGGAAGATTTATTTTTACTGAATAATATCTTATTAT
CTTGTGCGGACACTTATATTCGTTTGAAGATGTTCGGTCGTCTAAAAGAAACATTACAACTTAGCCACTTTATAATGTCA
ACTATTCAAGATTTTCAAAAAATGCCTATGTATTGTATGTATGAATGGAAGCTATCTATTTTTTATTTGAAAGATATTAA
CCGAGCACGGAATTACTTTGAACAGTCTATTTTATTTACTCAAATGACAGGAGATACATATTTAGTTCAAAAATTACGGG
GAGAATGGAATAAAGATATTCATTATATTTAA

Domains

Predicted by InterproScan.

• Helix-turn-helix (HTH_3) (12-64)

• ComR tetratricopeptide (ComR_TPR) (73-296)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comR	Streptococcus pyogenes MGAS315	99.34	100	0.993
comR	Streptococcus pyogenes MGAS8232	58.472	99.34	0.581
comR	Streptococcus mutans UA159	47.492	98.68	0.469
comR	Streptococcus infantarius subsp. infantarius ATCC BAA-102	46.441	97.36	0.452
comR	Streptococcus suis P1/7	37.374	98.02	0.366
comR	Streptococcus suis 05ZYH33	37.374	98.02	0.366