Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaH   Type   Regulator
Locus tag   ETT59_RS04195 Genome accession   NZ_CP035440
Coordinates   823789..825099 (+) Length   436 a.a.
NCBI ID   WP_011054528.1    Uniprot ID   A0A4U9BXV0
Organism   Streptococcus pyogenes strain emm124     
Function   Required for optimal comC expression (predicted from homology)   
Competence regulation

Genomic Context

Location: 818789..830099
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  ETT59_RS04175 (ETT59_04175) phoU 819380..820033 (+) 654 WP_002984514.1 phosphate signaling complex protein PhoU -
  ETT59_RS04185 (ETT59_04185) - 820238..822775 (+) 2538 WP_014407610.1 M1 family metallopeptidase -
  ETT59_RS04190 (ETT59_04190) ciaR 823122..823796 (+) 675 WP_002984519.1 response regulator transcription factor Regulator
  ETT59_RS04195 (ETT59_04195) ciaH 823789..825099 (+) 1311 WP_011054528.1 cell wall metabolism sensor histidine kinase WalK Regulator
  ETT59_RS04200 (ETT59_04200) rpsT 825224..825472 (-) 249 WP_009881183.1 30S ribosomal protein S20 -
  ETT59_RS04205 (ETT59_04205) coaA 825526..826446 (-) 921 WP_014407609.1 type I pantothenate kinase -
  ETT59_RS04210 (ETT59_04210) - 826714..827307 (+) 594 WP_053308373.1 class I SAM-dependent methyltransferase -
  ETT59_RS04215 (ETT59_04215) - 827960..828349 (+) 390 WP_011285547.1 cytidine deaminase -
  ETT59_RS04220 (ETT59_04220) - 828443..829495 (+) 1053 WP_002989701.1 BMP family protein -

Sequence

Protein


Download         Length: 436 a.a.        Molecular weight: 50112.66 Da        Isoelectric Point: 9.2692

>NTDB_id=341701 ETT59_RS04195 WP_011054528.1 823789..825099(+) (ciaH) [Streptococcus pyogenes strain emm124]
MNKLKKEILSDNYNHFFHFFAVFTGIFVIMTIIILQIMRFGVYSSVDSSLVSVSNNASSYANRTMARISSFYFDTENNII
KALPDSDSSKLLGTPAANTDIILFSANGTILNAFDAFSNYQNFHLDKRRLGSIETTSLMNFYGQEEKYHTITVRVHIKNY
PAVAYMMAVVNVEQLDRANERYERIIIIVMSVFWLISILASIYLAKWSRKPILESYEKQKMFVENASHELRTPLAVLQNR
LESLFRKPNETILENSEHLASSLDEVRNMRILTTNLLNLARRDDGINPQWTHLDTDFFNAIFENYELVAKEYGKIFYFQN
QVNRSLRMDKALLKQLITILFDNAIKYTDKNGIIEIIVKTTDKNLLISVIDNGPGITDEEKKKIFDRFYRVDKARTRQTG
GFGLGLALAQQIVMSLKGNITVKDNDPKGSIFEVKL

Nucleotide


Download         Length: 1311 bp        

>NTDB_id=341701 ETT59_RS04195 WP_011054528.1 823789..825099(+) (ciaH) [Streptococcus pyogenes strain emm124]
ATGAATAAATTAAAAAAAGAGATTTTATCAGATAACTATAACCACTTTTTTCATTTTTTTGCGGTTTTTACAGGTATTTT
TGTCATTATGACTATTATTATCTTACAGATTATGCGGTTTGGCGTTTATTCGTCAGTTGACAGTAGTTTAGTTTCTGTTA
GTAATAATGCAAGTAGCTATGCTAATCGTACGATGGCTAGAATATCTTCTTTTTACTTTGATACTGAAAATAACATTATT
AAGGCGCTGCCTGATTCAGATAGTTCTAAGTTATTAGGAACGCCTGCAGCTAATACAGATATCATTTTGTTTAGTGCTAA
TGGAACAATTTTAAATGCTTTTGATGCGTTTTCTAACTATCAAAATTTTCATTTAGATAAACGCCGGTTGGGGAGTATTG
AAACCACCAGTTTAATGAATTTTTATGGACAAGAAGAAAAATACCATACGATAACTGTAAGGGTTCATATCAAAAATTAT
CCTGCAGTTGCCTATATGATGGCAGTAGTAAATGTGGAACAATTAGACCGCGCTAATGAACGTTACGAGCGCATTATTAT
TATAGTTATGAGTGTTTTTTGGCTAATTTCTATTTTAGCAAGTATTTATTTAGCCAAGTGGAGCAGAAAACCTATTTTAG
AAAGCTATGAAAAACAAAAAATGTTTGTTGAAAATGCTAGTCATGAATTAAGGACCCCTTTGGCGGTCTTACAAAATCGT
CTGGAATCGCTTTTTCGTAAGCCCAACGAAACGATATTAGAAAATAGTGAGCATCTCGCTTCTAGTTTAGACGAGGTTCG
CAACATGCGCATCTTAACAACTAATTTATTAAATTTAGCAAGACGAGATGATGGCATTAATCCACAGTGGACTCATTTAG
ATACAGATTTTTTTAATGCTATTTTTGAGAATTATGAACTAGTTGCTAAAGAATATGGAAAAATATTTTATTTTCAGAAC
CAAGTCAATAGATCGTTAAGAATGGATAAGGCTTTACTAAAACAATTAATAACGATTTTATTTGACAATGCTATTAAATA
TACAGATAAAAATGGTATTATTGAAATTATAGTGAAAACAACGGACAAAAATTTATTAATTTCTGTTATTGATAATGGTC
CAGGGATAACAGATGAAGAAAAGAAAAAGATTTTTGATCGTTTTTATCGAGTTGACAAAGCTAGAACACGGCAAACAGGT
GGATTTGGCTTGGGGTTGGCTTTAGCTCAGCAAATCGTGATGTCTTTAAAAGGAAATATTACAGTAAAGGATAATGATCC
TAAAGGTAGTATTTTTGAAGTCAAACTATAA

Domains

Predicted by InterproScan.

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c)

(329-436)

His Kinase A (phospho-acceptor) domain (HisKA)

(220-285)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A4U9BXV0

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaH Streptococcus mutans UA159

57.895

100

0.58
  ciaH Streptococcus pneumoniae Rx1

51.37

100

0.516
  ciaH Streptococcus pneumoniae D39

51.37

100

0.516
  ciaH Streptococcus pneumoniae R6

51.37

100

0.516
  ciaH Streptococcus pneumoniae TIGR4

51.37

100

0.516

Multiple sequence alignment