Detailed information    

insolico Bioinformatically predicted

Overview

Name   hexB   Type   Machinery gene
Locus tag   SGPB_RS09945 Genome accession   NC_015600
Coordinates   2024837..2026759 (-) Length   640 a.a.
NCBI ID   WP_013852330.1    Uniprot ID   F5X3T9
Organism   Streptococcus pasteurianus ATCC 43144     
Function   DNA mismatch repair (predicted from homology)   
Homologous recombination

Genomic Context

Location: 2019837..2031759
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  SGPB_RS09920 (SGPB_1952) - 2020845..2021792 (-) 948 WP_230321698.1 MFS transporter -
  SGPB_RS09925 (SGPB_1953) - 2022385..2022687 (-) 303 WP_230321699.1 hypothetical protein -
  SGPB_RS11555 (SGPB_1955) - 2022988..2023164 (-) 177 WP_230321700.1 hypothetical protein -
  SGPB_RS09935 (SGPB_1956) - 2023311..2024162 (+) 852 WP_013852329.1 helix-turn-helix domain-containing protein -
  SGPB_RS09940 (SGPB_1957) ruvA 2024242..2024835 (-) 594 WP_003066922.1 Holliday junction branch migration protein RuvA Machinery gene
  SGPB_RS09945 (SGPB_1958) hexB 2024837..2026759 (-) 1923 WP_013852330.1 DNA mismatch repair endonuclease MutL Machinery gene
  SGPB_RS09950 (SGPB_1959) hexA 2026876..2029446 (-) 2571 WP_013852331.1 DNA mismatch repair protein MutS Machinery gene
  SGPB_RS09955 (SGPB_1960) - 2029433..2029789 (-) 357 WP_003066927.1 YlbF family regulator -
  SGPB_RS09960 (SGPB_1961) argR 2029786..2030223 (-) 438 WP_003066930.1 arginine repressor -

Sequence

Protein


Download         Length: 640 a.a.        Molecular weight: 72489.52 Da        Isoelectric Point: 5.2133

>NTDB_id=34139 SGPB_RS09945 WP_013852330.1 2024837..2026759(-) (hexB) [Streptococcus pasteurianus ATCC 43144]
MSKIIELPEVLANQIAAGEVIERPASVVKELVENSIDAGSSQITIEIEEAGLKKIQVTDNGEGIAQDDVALSLHRHATSK
IKNQADLFRIRTLGFRGEAIPSIASISHFTVKTATADENHGTLLVAKGGEIEKQEPISTPVGTKITVENLFYNTPARLKY
MKSLQSELAHIVDVVNRLSLAHPEVAFSLINDGRQMTTTSGTGDLRQAIAGIYGLNTAKKMIEISNADLDFEVSGYISLP
ELTRANRNYITILINGRYIKNFLLNRAILDGYGSKLMVGRFPIAVIDIQIDPYLADVNVHPTKQEVRISKEKELMSLISS
AIAESLREQDLIPDALENLAKSSTRGLPKPEQTSLPLKQTDLYYDKERRDFFVKSDTVEEQPVQLFNEVDKQQTSVKYAQ
RSEVDNQDDEHDNLDFKNKTKINKMIESLDNEESSTFPELDYFGQMHGTYLFAQGNGGLYIIDQHAAQERVKYEYYREKI
GDVDSSLQQLLMPYLFEFSGADFIKLQEKMELLNQVGIYLEPYGNNTFILREHPIWMKEEEIETAVYEMCDMLLLTNEVS
VKKYRAELAIMMSCKRSIKANHILDDYSARHLLVQLSQCKNPYNCPHGRPVLVNFTKADMEKMFRRIQENHTSLRELGKY

Nucleotide


Download         Length: 1923 bp        

>NTDB_id=34139 SGPB_RS09945 WP_013852330.1 2024837..2026759(-) (hexB) [Streptococcus pasteurianus ATCC 43144]
ATGAGTAAAATTATTGAGTTGCCAGAGGTTTTGGCTAACCAAATTGCAGCGGGTGAAGTTATTGAACGACCAGCTAGCGT
TGTCAAAGAATTGGTGGAAAATTCGATTGATGCAGGGAGCAGCCAAATCACCATTGAAATTGAAGAAGCTGGTTTAAAGA
AAATTCAAGTGACAGATAATGGCGAAGGAATTGCTCAAGATGATGTTGCATTAAGTTTGCACCGCCATGCCACAAGTAAA
ATTAAAAATCAAGCTGACCTTTTCCGTATTAGGACGTTAGGTTTTCGTGGTGAAGCGATACCGTCAATTGCCTCCATTAG
TCATTTTACAGTCAAAACAGCAACGGCAGATGAAAATCATGGAACATTGCTAGTAGCCAAAGGTGGTGAAATCGAAAAAC
AAGAACCGATTTCTACACCCGTTGGAACCAAAATTACGGTTGAAAATCTCTTTTATAATACGCCAGCACGTCTTAAATAC
ATGAAAAGTCTCCAATCCGAATTAGCTCATATTGTTGATGTGGTGAATCGTTTGAGTTTGGCGCACCCAGAGGTGGCTTT
TAGCTTGATTAATGATGGTCGTCAAATGACAACAACATCTGGTACTGGTGATTTGCGACAAGCAATTGCTGGTATTTATG
GGCTTAATACGGCTAAAAAAATGATTGAGATTTCGAATGCTGACCTCGATTTTGAAGTGTCTGGTTACATTAGTCTGCCA
GAATTGACACGAGCGAACCGAAACTATATTACGATTTTGATTAACGGTCGTTATATTAAAAACTTTTTGCTCAATCGTGC
GATTTTGGACGGTTATGGTTCAAAATTGATGGTGGGACGTTTTCCGATTGCTGTTATCGACATTCAAATCGACCCTTATT
TAGCTGATGTCAATGTTCACCCAACGAAGCAAGAAGTTCGTATTTCAAAGGAAAAAGAATTAATGAGCTTAATCAGCTCT
GCTATTGCAGAGAGTCTGCGTGAGCAAGATTTGATACCTGATGCTCTAGAAAATCTGGCGAAATCAAGCACACGTGGGCT
TCCGAAACCAGAGCAAACGAGCTTGCCGTTGAAACAAACAGATCTTTATTATGATAAAGAACGTCGTGATTTCTTTGTTA
AGTCAGATACGGTTGAAGAGCAACCAGTACAGTTATTCAATGAAGTTGACAAGCAACAAACATCAGTGAAATATGCGCAG
CGTTCCGAAGTAGATAATCAAGATGATGAACATGATAATCTCGATTTTAAAAACAAGACAAAAATCAATAAGATGATTGA
AAGTCTTGATAATGAGGAGTCATCAACTTTCCCAGAATTAGATTATTTCGGACAAATGCACGGAACGTATCTTTTTGCAC
AGGGAAATGGTGGGCTTTATATCATTGACCAACACGCTGCTCAAGAACGTGTTAAATATGAATATTATCGTGAGAAAATC
GGCGACGTTGACAGCTCTTTACAGCAGCTTCTCATGCCATACCTTTTTGAGTTTTCTGGAGCTGATTTTATTAAGTTGCA
AGAAAAAATGGAGCTGTTAAATCAAGTTGGTATTTATCTAGAACCATATGGAAACAACACTTTTATTCTCCGTGAACACC
CAATTTGGATGAAAGAAGAGGAAATTGAGACGGCTGTTTATGAGATGTGTGATATGCTGTTGTTGACAAATGAAGTATCG
GTGAAGAAATATCGTGCAGAATTGGCAATCATGATGTCATGCAAACGCTCAATCAAAGCGAATCACATTCTTGATGATTA
TTCCGCCCGACATCTTTTGGTTCAGTTATCACAATGTAAGAATCCTTATAACTGTCCACATGGACGTCCAGTTCTTGTCA
ACTTTACCAAAGCTGACATGGAAAAAATGTTCCGCCGTATTCAAGAAAATCACACAAGTTTAAGAGAGTTAGGAAAATAC
TAA

Domains

Predicted by InterProScan.

MutL C terminal dimerisation domain (MutL_C)

(442-584)

DNA mismatch repair protein, C-terminal domain (DNA_mis_repair)

(209-326)

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c_3)

(25-117)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB F5X3T9

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  hexB Streptococcus pneumoniae R6

71.669

100

0.731

Multiple sequence alignment