Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaR   Type   Regulator
Locus tag   CPH39_RS03590 Genome accession   NZ_CP043542
Coordinates   749491..750150 (-) Length   219 a.a.
NCBI ID   WP_001221493.1    Uniprot ID   Q3YXL4
Organism   Escherichia coli strain F2_81     
Function   repress competence development; post-transcriptional repression of CSP production (predicted from homology)   
Competence regulation

Genomic Context

Location: 744491..755150
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  CPH39_RS03565 (CPH39_03590) - 745234..746181 (+) 948 WP_001305988.1 iron-siderophore ABC transporter substrate-binding protein -
  CPH39_RS03570 (CPH39_03595) - 746178..747065 (+) 888 WP_000614953.1 MurR/RpiR family transcriptional regulator -
  CPH39_RS03575 (CPH39_03600) ygiN 747109..747423 (-) 315 WP_000958598.1 putative quinol monooxygenase -
  CPH39_RS03580 (CPH39_03605) mdaB 747454..748035 (-) 582 WP_000065431.1 NADPH:quinone oxidoreductase MdaB -
  CPH39_RS03585 (CPH39_03610) qseC 748145..749494 (-) 1350 WP_089553183.1 quorum sensing histidine kinase QseC -
  CPH39_RS03590 (CPH39_03615) ciaR 749491..750150 (-) 660 WP_001221493.1 quorum sensing response regulator transcription factor QseB Regulator
  CPH39_RS03595 (CPH39_03620) ygiW 750302..750694 (+) 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
  CPH39_RS03600 (CPH39_03625) ygiV 750747..751229 (+) 483 WP_053883111.1 GyrI-like domain-containing protein -
  CPH39_RS03605 (CPH39_03630) ygiS 751338..752945 (+) 1608 WP_053883112.1 ABC transporter substrate-binding protein -

Sequence

Protein


Download         Length: 219 a.a.        Molecular weight: 24687.63 Da        Isoelectric Point: 6.9850

>NTDB_id=338272 CPH39_RS03590 WP_001221493.1 749491..750150(-) (ciaR) [Escherichia coli strain F2_81]
MRILLIEDDMLIGDGIKTGLSKMGFSVDWFTQGRQGKEALYSAPYDAVILDLTLPGMDGRDILREWREKGQREPVLILTA
RDALAERVEGLRLGADDYLCKPFALIEVAARLEALMRRTNGQASNELRHGNVMLDPGKRIATLAGEPLTLKPKEFALLEL
LMRNAGRVLPRKLIEEKLYTWDEEVTSNAVEVHVHHLRRKLGSDFIRTVHGIGYTLGEK

Nucleotide


Download         Length: 660 bp        

>NTDB_id=338272 CPH39_RS03590 WP_001221493.1 749491..750150(-) (ciaR) [Escherichia coli strain F2_81]
ATGCGAATTTTACTGATAGAAGATGACATGCTGATTGGCGACGGCATCAAAACGGGCCTTAGTAAAATGGGTTTTAGCGT
CGACTGGTTTACACAAGGTCGTCAGGGAAAAGAGGCGCTTTATAGCGCGCCTTATGATGCGGTGATCCTGGATTTAACCT
TACCAGGCATGGATGGTCGCGATATTTTGCGCGAATGGCGAGAAAAAGGTCAGCGTGAGCCGGTACTGATCCTGACCGCG
CGCGATGCGCTGGCGGAACGTGTAGAGGGGCTGCGTCTGGGAGCTGACGATTATCTGTGTAAACCTTTTGCGTTGATAGA
AGTCGCCGCCAGGCTGGAAGCTCTGATGCGCCGAACCAACGGCCAGGCCAGCAACGAGCTGCGCCACGGTAACGTCATGC
TCGACCCCGGCAAACGTATCGCCACGCTGGCTGGCGAACCCTTAACACTGAAACCAAAAGAATTTGCCCTGCTGGAATTA
CTGATGCGTAACGCTGGTCGGGTACTGCCGCGCAAACTGATTGAAGAGAAACTGTATACCTGGGACGAAGAGGTCACCAG
TAATGCCGTTGAAGTGCATGTGCATCATCTGCGACGCAAACTCGGTAGTGATTTTATTCGTACCGTGCATGGTATTGGCT
ATACATTAGGTGAGAAATGA

Domains

Predicted by InterProScan.

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(145-216)

Response regulator receiver domain (Response_reg)

(3-112)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB Q3YXL4

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaR Streptococcus pneumoniae Rx1

38.326

100

0.397
  ciaR Streptococcus pneumoniae D39

38.326

100

0.397
  ciaR Streptococcus pneumoniae R6

38.326

100

0.397
  ciaR Streptococcus pneumoniae TIGR4

38.326

100

0.397
  ciaR Streptococcus mutans UA159

35.874

100

0.365

Multiple sequence alignment