Detailed information    

insolico Bioinformatically predicted

Overview

Name   comD/comD1   Type   Regulator
Locus tag   EQH29_RS10540 Genome accession   NZ_CP035251
Coordinates   2093851..2095176 (-) Length   441 a.a.
NCBI ID   WP_001813347.1    Uniprot ID   -
Organism   Streptococcus pneumoniae strain TVO_1901935     
Function   phosphorylation of ComE (predicted from homology)   
Competence regulation

Genomic Context

Location: 2088851..2100176
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  EQH29_RS10755 (EQH29_11140) - 2090535..2092138 (-) 1604 Protein_2053 YhgE/Pip family protein -
  EQH29_RS10520 (EQH29_11145) - 2092317..2092859 (+) 543 WP_001158266.1 TetR/AcrR family transcriptional regulator -
  EQH29_RS10535 (EQH29_11160) comE 2093102..2093854 (-) 753 WP_000866058.1 competence system response regulator transcription factor ComE Regulator
  EQH29_RS10540 (EQH29_11165) comD/comD1 2093851..2095176 (-) 1326 WP_001813347.1 competence system sensor histidine kinase ComD Regulator
  EQH29_RS10545 (EQH29_11170) comC/comC1 2095197..2095322 (-) 126 WP_000799689.1 competence-stimulating peptide ComC Regulator
  EQH29_RS10555 (EQH29_11180) rlmH 2095605..2096084 (-) 480 WP_000695929.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
  EQH29_RS10560 (EQH29_11185) htrA 2096267..2097448 (+) 1182 WP_000681601.1 S1C family serine protease Regulator
  EQH29_RS10565 (EQH29_11190) spo0J 2097506..2098264 (+) 759 WP_000410378.1 ParB/RepB/Spo0J family partition protein Regulator

Sequence

Protein


Download         Length: 441 a.a.        Molecular weight: 51226.76 Da        Isoelectric Point: 6.9339

>NTDB_id=337797 EQH29_RS10540 WP_001813347.1 2093851..2095176(-) (comD/comD1) [Streptococcus pneumoniae strain TVO_1901935]
MDLFGFGTVIVHLLIISHNYHLICKGQINRKELFVFGAYTLLTEIVFDFPLYILYLDGLGIAIFLFPLGLYSYFRWMKQY
ERDRGLFLSLLLSLLYESTHNFLSVTFSSITGDNFVLQYHFPFFFVVTVLTYFVTLKIIYYFHLELAYFDKDYLYPFLKK
VFFALLLLHIVSFVSDMVSTIKHLNSFGSILSSIVFISLLLTFFAMNSHKVQMEKEIALKQKKFEQKHLQNYTDEIVGLY
NEIRGFRHDYAGMLVSMQMAIDSGNLQEIDRIYNEVLVKANHKLRSDKYTYFDLNNIEDSALRSLVAQSIVYARNNGVEF
TLEVKDTITKLPIELLDLVRIMSVLLNNAVEGSADSYKKQMEVAVIKMETETVIVIQNSCKMTMTPSGDLFSLGFSTKGR
NRGVGLNNVKELLDKYNNIILETEMEGSTFRQIIRFKREFE

Nucleotide


Download         Length: 1326 bp        

>NTDB_id=337797 EQH29_RS10540 WP_001813347.1 2093851..2095176(-) (comD/comD1) [Streptococcus pneumoniae strain TVO_1901935]
ATGGATTTATTTGGATTTGGGACAGTTATTGTTCATCTTTTAATTATTAGTCACAACTACCATTTAATTTGTAAAGGTCA
AATAAATAGAAAAGAATTATTCGTTTTTGGTGCTTATACATTACTAACAGAAATAGTATTTGATTTTCCCTTATATATTC
TATATTTAGATGGGTTAGGGATTGCAATATTTTTATTTCCTTTGGGCTTATATTCCTATTTTCGATGGATGAAACAGTAT
GAGAGGGATAGAGGACTATTCCTAAGTTTACTACTATCTCTTTTATATGAGAGCACTCATAACTTTCTGTCCGTAACTTT
CTCCTCTATAACAGGAGATAATTTTGTTTTACAATATCATTTCCCATTCTTTTTCGTTGTGACGGTGTTAACCTATTTTG
TTACATTAAAAATCATTTATTATTTCCATTTGGAACTAGCCTATTTTGACAAGGACTACCTTTATCCTTTCTTGAAAAAA
GTATTTTTTGCTTTACTATTGCTACATATTGTATCTTTCGTTTCAGATATGGTAAGTACGATTAAACATTTGAATAGTTT
TGGAAGTATTTTGTCATCTATTGTCTTTATCTCTCTCCTTTTGACCTTCTTTGCAATGAATTCTCATAAAGTTCAAATGG
AGAAAGAGATTGCTTTGAAGCAGAAGAAATTTGAACAGAAACATTTACAGAATTACACAGATGAAATTGTCGGTCTGTAT
AATGAAATCCGTGGTTTTCGACATGATTATGCTGGGATGCTTGTCAGCATGCAGATGGCAATTGACAGTGGTAATTTACA
GGAAATTGACAGAATTTACAATGAAGTTTTAGTCAAAGCAAATCATAAATTGCGTTCAGATAAGTACACTTACTTTGATT
TGAACAACATAGAAGACTCAGCTTTACGAAGTTTGGTTGCTCAGTCAATTGTCTATGCTCGAAATAATGGTGTAGAGTTT
ACACTGGAAGTAAAAGATACGATTACCAAGCTTCCAATTGAACTATTGGATTTGGTTCGTATCATGAGCGTTTTATTGAA
TAATGCTGTCGAAGGATCGGCTGATAGCTATAAAAAGCAGATGGAAGTAGCAGTTATTAAGATGGAAACTGAAACAGTTA
TTGTGATTCAGAATTCATGTAAAATGACGATGACTCCTTCAGGAGATCTATTTTCCTTAGGATTCTCCACTAAGGGAAGA
AATCGCGGAGTCGGATTAAATAATGTGAAAGAACTACTAGATAAGTACAACAATATTATTTTAGAAACAGAGATGGAAGG
CAGTACATTTAGACAAATCATTAGATTTAAGAGGGAATTTGAATGA

Domains

Predicted by InterproScan.

GHKL domain (HATPase_c_5)

(334-434)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comD/comD1 Streptococcus pneumoniae Rx1

98.413

100

0.984
  comD/comD1 Streptococcus pneumoniae D39

98.413

100

0.984
  comD/comD1 Streptococcus pneumoniae R6

98.413

100

0.984
  comD/comD2 Streptococcus pneumoniae TIGR4

96.145

100

0.961
  comD Streptococcus mitis SK321

91.837

100

0.918
  comD Streptococcus mitis NCTC 12261

85.941

100

0.859
  comD/comD2 Streptococcus gordonii strain NCTC7865

49.604

85.941

0.426
  comD/comD1 Streptococcus gordonii str. Challis substr. CH1

49.465

84.807

0.419

Multiple sequence alignment