Detailed information    

insolico Bioinformatically predicted

Overview

Name   cclA/cilC   Type   Machinery gene
Locus tag   EQH32_RS08345 Genome accession   NZ_CP035248
Coordinates   1640399..1641058 (+) Length   219 a.a.
NCBI ID   WP_000565021.1    Uniprot ID   C1C962
Organism   Streptococcus pneumoniae strain TVO_1901939     
Function   processing and translocation of ComGC; assembly of the pseudopilus (predicted from homology)   
DNA binding and uptake

Genomic Context

Location: 1635399..1646058
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  EQH32_RS08325 (EQH32_08750) - 1636036..1636932 (-) 897 WP_000825669.1 PEP phosphonomutase -
  EQH32_RS08330 (EQH32_08755) - 1636935..1638197 (-) 1263 WP_000413336.1 PTS sugar transporter subunit IIC -
  EQH32_RS08335 (EQH32_08760) - 1638477..1639655 (+) 1179 WP_000175875.1 ROK family transcriptional regulator -
  EQH32_RS08340 (EQH32_08765) - 1639883..1640329 (-) 447 WP_000155418.1 GNAT family N-acetyltransferase -
  EQH32_RS08345 (EQH32_08770) cclA/cilC 1640399..1641058 (+) 660 WP_000565021.1 A24 family peptidase Machinery gene
  EQH32_RS08350 (EQH32_08775) - 1641110..1642261 (-) 1152 WP_000481760.1 XRE family transcriptional regulator -
  EQH32_RS08355 (EQH32_08780) - 1642276..1643007 (-) 732 Protein_1670 hypothetical protein -
  EQH32_RS08360 (EQH32_08785) - 1643227..1643337 (+) 111 Protein_1671 prepilin peptidase -
  EQH32_RS08365 (EQH32_08790) trpA 1643309..1644085 (-) 777 WP_001127048.1 tryptophan synthase subunit alpha -
  EQH32_RS08370 (EQH32_08795) trpB 1644078..1645301 (-) 1224 WP_000331287.1 tryptophan synthase subunit beta -
  EQH32_RS08375 (EQH32_08800) - 1645279..1645878 (-) 600 WP_000169887.1 phosphoribosylanthranilate isomerase -

Sequence

Protein


Download         Length: 219 a.a.        Molecular weight: 24854.98 Da        Isoelectric Point: 7.9575

>NTDB_id=337603 EQH32_RS08345 WP_000565021.1 1640399..1641058(+) (cclA/cilC) [Streptococcus pneumoniae strain TVO_1901939]
MIDFYFFLVGSILASFLGLVIDRFPEQSIISSASHCDSCQTRLRPLDLIPILSQVFNRFRCRYCKVRYPVWYALFELVLG
LLFLLYSWELLSLGQVVLITAGLTLGIYDFRHQEYPLLVWMTFHLILIASSGWNLVMVSFLALGILAHFIDIRMGAGDFL
FLASCALVFSVTELLILIQFASATGILAFLLQKKKERLPFVPFLLLAACVIIFGKLLLV

Nucleotide


Download         Length: 660 bp        

>NTDB_id=337603 EQH32_RS08345 WP_000565021.1 1640399..1641058(+) (cclA/cilC) [Streptococcus pneumoniae strain TVO_1901939]
ATGATTGATTTTTATTTTTTTCTCGTCGGGAGCATTCTCGCTTCCTTTCTTGGTTTGGTCATTGACCGTTTTCCAGAGCA
ATCCATTATCAGTTCAGCCAGTCACTGCGATTCCTGTCAGACTCGCTTGCGTCCCTTAGATTTGATTCCGATTCTCTCAC
AGGTCTTCAATCGCTTTCGCTGTCGCTACTGCAAAGTTCGCTATCCTGTCTGGTATGCCCTCTTTGAATTAGTCTTAGGA
CTCCTCTTTCTGCTTTACTCTTGGGAATTGCTTTCCTTGGGGCAAGTCGTCCTAATCACCGCTGGTTTGACCTTAGGCAT
CTACGACTTTCGCCATCAGGAATATCCCTTACTGGTCTGGATGACTTTCCACCTAATCCTAATAGCTTCCTCTGGCTGGA
ATCTGGTCATGGTCTCCTTCCTTGCTCTTGGAATTTTGGCTCATTTTATCGATATCCGCATGGGCGCAGGAGATTTCCTC
TTTTTAGCTTCTTGTGCTCTCGTCTTTAGCGTAACGGAGTTACTGATCTTGATTCAGTTCGCTTCTGCGACGGGTATTCT
GGCCTTTCTCCTGCAAAAGAAAAAGGAAAGACTTCCTTTCGTGCCTTTCCTCTTACTTGCTGCTTGTGTGATTATTTTTG
GTAAGCTACTGCTTGTCTGA

Domains

Predicted by InterproScan.

Bacterial Peptidase A24 N-terminal domain (A24_N_bact)

(8-89)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB C1C962

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  cclA/cilC Streptococcus pneumoniae Rx1

97.717

100

0.977
  cclA/cilC Streptococcus pneumoniae D39

97.717

100

0.977
  cclA/cilC Streptococcus pneumoniae R6

97.717

100

0.977
  cclA/cilC Streptococcus pneumoniae TIGR4

95.89

100

0.959
  cclA/cilC Streptococcus mitis SK321

93.151

100

0.932
  cclA/cilC Streptococcus mitis NCTC 12261

87.671

100

0.877

Multiple sequence alignment