Detailed information NTG0337036

Bioinformatically predicted

Overview

• Name: comE/blpR
• Type: Regulator
• Locus tag: EQH39_RS02250
• Genome accession: NZ_CP035241
• Coordinates: 452873..453610 (+)
• Length: 245 a.a.
• NCBI ID: WP_001219123.1
• Uniprot ID: A0A4J1SVB2
• Organism: Streptococcus pneumoniae strain TVO_1901948
• Function: activate transcription of early competence genes; regulation of comX expression (predicted from homology) Competence regulation

Genomic Context

Location: 447873..458610

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
EQH39_RS02215	-	448804..449043 (-)	240	WP_001812223.1	hypothetical protein	-
EQH39_RS02220 (EQH39_02335)	-	449205..449492 (-)	288	WP_000777760.1	hypothetical protein	-
EQH39_RS02225 (EQH39_02340)	-	449502..449912 (-)	411	WP_001278301.1	HIT family protein	-
EQH39_RS02230 (EQH39_02345)	pptA	449980..450711 (+)	732	WP_000889919.1	ABC transporter ATP-binding protein	Regulator
EQH39_RS02235 (EQH39_02350)	-	450708..451757 (+)	1050	WP_000653766.1	ABC transporter permease	-
EQH39_RS02240 (EQH39_02360)	-	451925..452254 (-)	330	WP_000132572.1	hypothetical protein	-
EQH39_RS02245 (EQH39_02365)	-	452530..452868 (+)	339	WP_000876670.1	LytTR family DNA-binding domain-containing protein	-
EQH39_RS02250 (EQH39_02370)	comE/blpR	452873..453610 (+)	738	WP_001219123.1	response regulator transcription factor	Regulator
EQH39_RS02255 (EQH39_02375)	-	453624..454964 (+)	1341	WP_001028654.1	sensor histidine kinase	-
EQH39_RS02260 (EQH39_02380)	blpC	455009..455164 (-)	156	WP_000358810.1	quorum-sensing system pheromone BlpC	-
EQH39_RS02265 (EQH39_02385)	-	455221..456582 (-)	1362	WP_001069085.1	bacteriocin secretion accessory protein	-
EQH39_RS02270 (EQH39_02390)	comA/nlmT	456593..458269 (-)	1677	WP_307774231.1	peptide cleavage/export ABC transporter	Regulator

Sequence

Protein

• Length: 245 a.a.
• Molecular weight: 28784.92 Da
• Isoelectric Point: 6.2361

>NTDB_id=337036 EQH39_RS02250 WP_001219123.1 452873..453610(+) (comE/blpR) [Streptococcus pneumoniae strain TVO_1901948]
MRIFVLEDDFSQQTRIETTIEKLLKAHHIIPSSFEVFGKPDQLLAEVHEKGAHQLFFLDIEIRNEEMKGLEVARKIRDRD
PYALIVFVTTHSEFMPLSFRYQVSALDYIDKALSAEEFESRIETDLLYANSQDSKSLAEDCFYFKSKFAQFQYPFKEVYY
LETSPRAHRVILYTKTDRLEFTASLEEVFKQEPRLLQCHRSFLINPANVVHLDKKEKLLFFPNGGSCLIARYKVREVSEA
INNLH

Nucleotide

• Length: 738 bp

>NTDB_id=337036 EQH39_RS02250 WP_001219123.1 452873..453610(+) (comE/blpR) [Streptococcus pneumoniae strain TVO_1901948]
ATGAGAATATTTGTTTTAGAGGATGATTTTTCCCAACAGACTAGAATTGAAACGACGATTGAGAAACTTTTGAAAGCACA
TCATATCATTCCTAGCTCTTTTGAGGTATTTGGCAAGCCGGACCAACTGCTGGCTGAAGTGCATGAGAAGGGGGCCCATC
AGCTATTCTTTTTGGATATTGAGATTCGAAATGAAGAGATGAAGGGACTGGAAGTGGCTAGAAAGATTCGGGATCGGGAT
CCTTATGCCCTGATTGTCTTTGTGACGACTCACTCGGAGTTTATGCCCCTGTCCTTTCGCTACCAAGTGTCTGCTCTGGA
CTATATTGATAAGGCCCTTTCGGCAGAGGAGTTTGAATCTCGAATCGAGACAGACCTCCTCTATGCCAATAGTCAAGATA
GTAAAAGTCTGGCGGAAGATTGCTTTTACTTTAAATCAAAATTTGCCCAATTCCAATATCCTTTTAAAGAGGTTTACTAT
CTCGAAACGTCTCCCAGAGCCCATCGTGTTATTCTCTATACCAAGACAGACAGGCTGGAATTTACAGCGAGTTTAGAGGA
GGTTTTCAAGCAGGAACCCCGTCTCTTGCAGTGCCATCGCTCTTTTCTCATCAATCCTGCAAATGTGGTGCATTTGGATA
AGAAAGAAAAACTCCTTTTTTTTCCCAATGGTGGAAGTTGTCTGATCGCGCGTTATAAGGTCAGGGAAGTGTCTGAGGCT
ATTAATAACTTACACTGA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (3-122)

• LytTr DNA-binding domain (LytTR) (151-241)

3D structure

• AlphaFold DB: A0A4J1SVB2

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE/blpR	Streptococcus mutans UA159	53.909	99.184	0.535
comE/comE1	Streptococcus equinus JB1	43.46	96.735	0.42
comE/comE2	Streptococcus equinus JB1	38.43	98.776	0.38