Detailed information NTG0336956

Bioinformatically predicted

Overview

• Name: comE/blpR
• Type: Regulator
• Locus tag: EQH41_RS02445
• Genome accession: NZ_CP035239
• Coordinates: 505820..506557 (+)
• Length: 245 a.a.
• NCBI ID: WP_001219120.1
• Uniprot ID: Q9S1I6
• Organism: Streptococcus pneumoniae strain TVO_TIGR4
• Function: activate transcription of early competence genes; regulation of comX expression (predicted from homology) Competence regulation

Genomic Context

Location: 500820..511557

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
EQH41_RS02415 (EQH41_02595)	-	502152..502439 (-)	288	WP_000777760.1	hypothetical protein	-
EQH41_RS02420 (EQH41_02600)	-	502449..502859 (-)	411	WP_001278301.1	HIT family protein	-
EQH41_RS02425 (EQH41_02605)	pptA	502927..503658 (+)	732	WP_000889924.1	ABC transporter ATP-binding protein	Regulator
EQH41_RS02430 (EQH41_02610)	-	503655..504704 (+)	1050	WP_000653779.1	ABC transporter permease	-
EQH41_RS02435 (EQH41_02620)	-	504872..505201 (-)	330	WP_000132572.1	hypothetical protein	-
EQH41_RS02440 (EQH41_02625)	-	505477..505815 (+)	339	WP_000876675.1	LytTR family DNA-binding domain-containing protein	-
EQH41_RS02445 (EQH41_02630)	comE/blpR	505820..506557 (+)	738	WP_001219120.1	LytTR family DNA-binding domain-containing protein	Regulator
EQH41_RS02450 (EQH41_02635)	-	506571..507911 (+)	1341	WP_001017646.1	sensor histidine kinase	-
EQH41_RS02455 (EQH41_02640)	blpC	507982..508110 (-)	129	WP_000358815.1	quorum-sensing system pheromone BlpC	-
EQH41_RS02460 (EQH41_02645)	-	508167..509528 (-)	1362	WP_001069075.1	bacteriocin secretion accessory protein	-
EQH41_RS10960 (EQH41_02650)	comA/nlmT	509539..510186 (-)	648	WP_078064020.1	ATP-binding cassette domain-containing protein	Regulator
EQH41_RS10965 (EQH41_02655)	comA/nlmT	510202..511215 (-)	1014	WP_307772067.1	ABC transporter transmembrane domain-containing protein	Regulator

Sequence

Protein

• Length: 245 a.a.
• Molecular weight: 28754.98 Da
• Isoelectric Point: 6.5884

>NTDB_id=336956 EQH41_RS02445 WP_001219120.1 505820..506557(+) (comE/blpR) [Streptococcus pneumoniae strain TVO_TIGR4]
MRIFVLEDDFSQQTRIETTIEKLLKAHHIIPSSFEVFGKPDQLLAEVHEKGAHQLFFLDIEIRNEEMKGLEVARKIRDRD
PYALIVFVTTHSEFMPLSFRYQVSALDYIDKALSAEEFESRIETALLYANSQDSKSLAEDCFYFKSKFAQFQYPFKEVYY
LETSPRAHRVILYTKTDRLEFTASLEEVFKQEPRLLQCHRSFLINPANVVHLDKKEKLLFFPNGGSCLIARYKVREVSEA
INKLH

Nucleotide

• Length: 738 bp

>NTDB_id=336956 EQH41_RS02445 WP_001219120.1 505820..506557(+) (comE/blpR) [Streptococcus pneumoniae strain TVO_TIGR4]
ATGAGAATATTTGTTTTAGAGGATGATTTTTCCCAACAGACTAGAATTGAAACGACGATTGAGAAACTTTTGAAAGCACA
TCATATCATTCCTAGCTCTTTTGAGGTATTTGGCAAGCCGGACCAACTGCTGGCTGAAGTGCATGAGAAGGGGGCCCATC
AGCTATTCTTTTTGGATATTGAGATTCGAAATGAAGAGATGAAGGGACTGGAAGTGGCTAGAAAGATTCGGGATCGGGAT
CCTTATGCCCTGATTGTCTTTGTGACGACTCACTCGGAGTTTATGCCCCTGTCTTTTCGCTACCAAGTGTCTGCTTTGGA
CTACATTGATAAGGCCTTGTCAGCAGAGGAGTTTGAATCTCGGATCGAGACAGCCCTCCTCTATGCCAATAGTCAAGATA
GTAAAAGTCTGGCGGAAGATTGCTTTTACTTTAAATCAAAATTTGCCCAATTTCAGTATCCTTTTAAAGAGGTTTACTAT
CTCGAAACGTCGCCCAGAGCCCATCGTGTTATTCTCTATACCAAGACAGACAGGCTGGAATTTACAGCGAGTTTAGAGGA
GGTTTTCAAGCAGGAGCCCCGTCTCTTGCAGTGCCACCGCTCTTTTCTCATCAATCCTGCAAATGTGGTGCATTTGGATA
AGAAAGAAAAACTGCTTTTCTTTCCCAATGGTGGAAGTTGTCTAATCGCCCGTTATAAGGTCAGGGAAGTGTCTGAGGCC
ATCAATAAATTACACTGA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (3-122)

• LytTr DNA-binding domain (LytTR) (151-241)

3D structure

• AlphaFold DB: Q9S1I6

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE/blpR	Streptococcus mutans UA159	54.321	99.184	0.539
comE/comE1	Streptococcus equinus JB1	43.46	96.735	0.42
comE/comE2	Streptococcus equinus JB1	38.017	98.776	0.376
comE	Streptococcus infantis strain Atu-4	35.887	100	0.363