Detailed information    

insolico Bioinformatically predicted

Overview

Name   comM   Type   Regulator
Locus tag   EQH42_RS08790 Genome accession   NZ_CP035238
Coordinates   1737696..1738316 (-) Length   206 a.a.
NCBI ID   WP_000839908.1    Uniprot ID   A0A0B7M636
Organism   Streptococcus pneumoniae strain TVO_D39     
Function   fratricide immunity (predicted from homology)   
Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
Genomic island 1726977..1749384 1737696..1738316 within 0


Gene organization within MGE regions


Location: 1726977..1749384
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  EQH42_RS08725 (EQH42_09225) - 1726977..1727174 (-) 198 WP_000890144.1 hypothetical protein -
  EQH42_RS08730 (EQH42_09230) - 1727178..1727972 (-) 795 WP_001101210.1 hypothetical protein -
  EQH42_RS08735 (EQH42_09235) - 1728380..1728805 (-) 426 WP_000204065.1 hypothetical protein -
  EQH42_RS08740 (EQH42_09240) - 1728934..1729293 (-) 360 WP_000749822.1 ImmA/IrrE family metallo-endopeptidase -
  EQH42_RS08745 (EQH42_09245) - 1729339..1729545 (-) 207 WP_000366091.1 hypothetical protein -
  EQH42_RS08750 (EQH42_09250) - 1729532..1729705 (-) 174 WP_000289349.1 helix-turn-helix domain-containing protein -
  EQH42_RS08755 (EQH42_09255) lytA 1730064..1731020 (-) 957 WP_000405235.1 N-acetylmuramoyl-L-alanine amidase LytA -
  EQH42_RS08760 (EQH42_09260) - 1731396..1732766 (-) 1371 WP_001036271.1 MATE family efflux transporter -
  EQH42_RS08765 (EQH42_09270) recA 1733073..1734239 (-) 1167 WP_001085462.1 recombinase RecA Machinery gene
  EQH42_RS08770 (EQH42_09275) cinA 1734294..1735550 (-) 1257 WP_000642701.1 competence/damage-inducible protein A Machinery gene
  EQH42_RS08775 (EQH42_09280) brpA 1735635..1736651 (-) 1017 WP_000239282.1 biofilm formation/cell division transcriptional regulator BrpA -
  EQH42_RS08780 (EQH42_09285) - 1736659..1737177 (-) 519 WP_000455537.1 GNAT family N-acetyltransferase -
  EQH42_RS08785 (EQH42_09290) tsaE 1737167..1737610 (-) 444 WP_000288232.1 tRNA (adenosine(37)-N6)-threonylcarbamoyltransferase complex ATPase subunit type 1 TsaE -
  EQH42_RS08790 (EQH42_09295) comM 1737696..1738316 (-) 621 WP_000839908.1 hypothetical protein Regulator
  EQH42_RS08795 (EQH42_09305) - 1738699..1739562 (-) 864 WP_001093641.1 helix-turn-helix domain-containing protein -
  EQH42_RS10475 (EQH42_09310) - 1739754..1739924 (+) 171 WP_001227862.1 PhrA family quorum-sensing system peptide -
  EQH42_RS08800 (EQH42_09315) pneA1 1740027..1740251 (+) 225 WP_000181087.1 two-peptide bacteriocin subunit PneA1 -
  EQH42_RS08805 (EQH42_09320) pneA2 1740258..1740446 (+) 189 WP_000786759.1 two-peptide bacteriocin subunit PneA2 -
  EQH42_RS08810 (EQH42_09325) - 1740562..1743552 (+) 2991 WP_000875575.1 type 2 lanthipeptide synthetase LanM family protein -
  EQH42_RS08815 (EQH42_09330) - 1743902..1744606 (+) 705 WP_001033170.1 flavodoxin family protein -
  EQH42_RS08820 (EQH42_09335) - 1744587..1745516 (+) 930 WP_000912955.1 M50 family metallopeptidase -
  EQH42_RS08825 (EQH42_09340) - 1745513..1747621 (+) 2109 WP_000701298.1 peptidase domain-containing ABC transporter -
  EQH42_RS08830 (EQH42_09345) - 1747645..1749384 (+) 1740 WP_000699969.1 S8 family serine peptidase -

Sequence

Protein


Download         Length: 206 a.a.        Molecular weight: 23552.72 Da        Isoelectric Point: 10.1254

>NTDB_id=336916 EQH42_RS08790 WP_000839908.1 1737696..1738316(-) (comM) [Streptococcus pneumoniae strain TVO_D39]
MKSMRILFLLALIQISLSSCFLWKECILSFKQSTAFFIGSMVFVSGICAGVNYLYTRKQEVHSVLASKKSVKLFYSMLLL
INLLGAVLVLSDNLFIKNTLQQELVDFLLPSFFFLFGLDLLIFLPLKKYVRDFLAMLDRKKTVLVTILATLLFLRNPMTI
VSLLIYIGLGLFFAAYLVPNSVKKEVSFYGHIFRDLVLVIVTLIFF

Nucleotide


Download         Length: 621 bp        

>NTDB_id=336916 EQH42_RS08790 WP_000839908.1 1737696..1738316(-) (comM) [Streptococcus pneumoniae strain TVO_D39]
ATGAAATCAATGAGAATCTTATTTTTGTTAGCTTTAATTCAAATCAGTTTGAGTAGCTGTTTCCTATGGAAGGAATGCAT
CTTGTCCTTTAAACAAAGTACAGCTTTTTTCATCGGAAGCATGGTTTTCGTTTCAGGAATCTGTGCTGGAGTAAATTATC
TTTATACCCGTAAGCAAGAAGTCCATAGTGTCCTAGCCAGTAAGAAGTCGGTGAAGCTTTTTTACAGTATGTTACTCTTA
ATTAATTTGTTAGGAGCTGTTCTTGTTTTGTCAGATAACTTGTTCATCAAAAATACGCTGCAGCAAGAATTAGTTGACTT
TTTATTGCCATCCTTCTTTTTCCTATTTGGGCTAGATTTGCTGATTTTTTTACCCTTGAAAAAATACGTGCGCGATTTTC
TTGCTATGCTGGACAGAAAAAAGACAGTGTTGGTGACTATTTTAGCAACACTTCTTTTCTTAAGAAATCCAATGACCATT
GTCTCACTTCTGATTTATATTGGACTGGGCTTGTTTTTTGCAGCCTATCTTGTCCCAAATTCGGTTAAGAAGGAAGTTTC
CTTTTATGGTCATATTTTCCGAGATCTTGTATTGGTCATTGTTACGCTCATTTTCTTTTAG

Domains


No domain identified.



Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A0B7M636

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comM Streptococcus pneumoniae D39

100

100

1
  comM Streptococcus pneumoniae R6

100

100

1
  comM Streptococcus pneumoniae TIGR4

100

100

1
  comM Streptococcus mitis NCTC 12261

38.974

94.66

0.369
  comM Streptococcus mitis SK321

38.974

94.66

0.369

Multiple sequence alignment