Detailed information    

insolico Bioinformatically predicted

Overview

Name   comE/blpR   Type   Regulator
Locus tag   EQH43_RS02740 Genome accession   NZ_CP035237
Coordinates   528898..529635 (+) Length   245 a.a.
NCBI ID   WP_001219126.1    Uniprot ID   A7XHJ0
Organism   Streptococcus pneumoniae strain TVO_Taiwan19F-14     
Function   activate transcription of early competence genes; regulation of comX expression (predicted from homology)   
Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
IScluster/Tn 526867..532574 528898..529635 within 0


Gene organization within MGE regions


Location: 526867..532574
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  EQH43_RS02730 (EQH43_02880) - 526867..528213 (-) 1347 WP_001816270.1 IS1380-like element ISSpn5 family transposase -
  EQH43_RS02735 (EQH43_02885) - 528555..528893 (+) 339 WP_000682122.1 LytTR family DNA-binding domain-containing protein -
  EQH43_RS02740 (EQH43_02890) comE/blpR 528898..529635 (+) 738 WP_001219126.1 response regulator transcription factor Regulator
  EQH43_RS02745 (EQH43_02895) - 529648..530988 (+) 1341 WP_000275284.1 sensor histidine kinase -
  EQH43_RS02750 (EQH43_02900) - 531228..532574 (-) 1347 WP_001816270.1 IS1380-like element ISSpn5 family transposase -

Sequence

Protein


Download         Length: 245 a.a.        Molecular weight: 28752.92 Da        Isoelectric Point: 6.2357

>NTDB_id=336804 EQH43_RS02740 WP_001219126.1 528898..529635(+) (comE/blpR) [Streptococcus pneumoniae strain TVO_Taiwan19F-14]
MRIFVLEDDFSQQTRIETTIEKLLKAHHIIPSSFEVFGKPDQLLAEVHEKGAHQLFFLDIEIRNEEMKGLEVARKIREQD
PYALIVFVTTHSEFMPLSFRYQVSALDYIDKALSAEEFESRIETALLYANSQDSKSLAEDCFYFKSKFAQFQYPFKEVYY
LETSPRPHRVILYTKTDRLEFTASLEEVFKQEPRLLQCHRSFLINPANVVHLDKKEKLLFFPNGGSCLIARYKVREVSEA
INNLH

Nucleotide


Download         Length: 738 bp        

>NTDB_id=336804 EQH43_RS02740 WP_001219126.1 528898..529635(+) (comE/blpR) [Streptococcus pneumoniae strain TVO_Taiwan19F-14]
ATGAGAATATTTGTTTTAGAAGATGATTTTTCCCAACAGACTAGAATTGAAACGACGATTGAGAAACTTTTGAAAGCACA
TCATATCATTCCTAGCTCTTTTGAGGTATTTGGCAAGCCGGACCAACTGCTGGCAGAGGTGCATGAGAAGGGGGCCCATC
AGCTATTCTTTTTGGATATTGAGATTCGAAATGAAGAGATGAAGGGACTGGAAGTGGCTAGAAAGATTCGGGAACAAGAC
CCTTATGCCCTAATCGTCTTTGTGACGACTCACTCGGAGTTTATGCCTCTGTCCTTTCGCTACCAAGTGTCAGCTTTGGA
CTACATTGATAAGGCCCTTTCGGCAGAGGAGTTTGAATCTCGTATCGAGACAGCCCTCCTCTATGCCAATAGTCAAGATA
GTAAAAGTCTGGCGGAAGATTGCTTTTACTTTAAATCAAAATTTGCCCAATTCCAATATCCTTTCAAAGAGGTTTACTAT
CTCGAAACATCCCCAAGACCCCATCGTGTTATTCTCTATACCAAGACGGACAGGCTAGAATTTACGGCGAGTTTAGAGGA
GGTTTTTAAGCAGGAACCCCGTCTCTTGCAGTGCCATCGCTCTTTTCTCATCAATCCTGCAAATGTGGTGCATTTGGATA
AGAAAGAAAAACTCCTTTTCTTTCCCAATGGTGGAAGCTGTCTGATCGCGCGTTATAAGGTCAGGGAAGTGTCTGAGGCT
ATTAATAACTTACACTGA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(3-122)

LytTr DNA-binding domain (LytTR)

(151-241)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A7XHJ0

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comE/blpR Streptococcus mutans UA159

53.909

99.184

0.535
  comE/comE1 Streptococcus equinus JB1

43.882

96.735

0.424
  comE/comE2 Streptococcus equinus JB1

38.843

98.776

0.384

Multiple sequence alignment