Detailed information    

insolico Bioinformatically predicted

Overview

Name   comD/comD1   Type   Regulator
Locus tag   EQH44_RS10625 Genome accession   NZ_CP035236
Coordinates   2098955..2100280 (-) Length   441 a.a.
NCBI ID   WP_025169508.1    Uniprot ID   A0AAP5J8J7
Organism   Streptococcus pneumoniae strain TVO_1902282     
Function   phosphorylation of ComE (predicted from homology)   
Competence regulation

Genomic Context

Location: 2093955..2105280
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  EQH44_RS10595 (EQH44_11195) - 2094133..2095386 (+) 1254 WP_000649625.1 IS110 family transposase -
  EQH44_RS10600 (EQH44_11200) - 2095646..2096188 (+) 543 WP_001158266.1 TetR/AcrR family transcriptional regulator -
  EQH44_RS10615 (EQH44_11215) - 2096549..2097946 (+) 1398 WP_001812112.1 ISNCY-like element IS1202 family transposase -
  EQH44_RS10770 - 2098019..2098144 (+) 126 WP_001258159.1 hypothetical protein -
  EQH44_RS10620 (EQH44_11220) comE 2098206..2098958 (-) 753 WP_000866075.1 competence system response regulator transcription factor ComE Regulator
  EQH44_RS10625 (EQH44_11225) comD/comD1 2098955..2100280 (-) 1326 WP_025169508.1 competence system sensor histidine kinase ComD Regulator
  EQH44_RS10630 (EQH44_11230) comC 2100293..2100424 (-) 132 WP_061649796.1 competence-stimulating peptide ComC Regulator
  EQH44_RS10640 (EQH44_11240) rlmH 2100706..2101185 (-) 480 WP_000695929.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
  EQH44_RS10645 (EQH44_11245) htrA 2101368..2102549 (+) 1182 WP_000681598.1 S1C family serine protease Regulator
  EQH44_RS10650 (EQH44_11250) spo0J 2102607..2103365 (+) 759 WP_000410381.1 ParB/RepB/Spo0J family partition protein Regulator

Sequence

Protein


Download         Length: 441 a.a.        Molecular weight: 51434.07 Da        Isoelectric Point: 6.9747

>NTDB_id=336788 EQH44_RS10625 WP_025169508.1 2098955..2100280(-) (comD/comD1) [Streptococcus pneumoniae strain TVO_1902282]
MDFFLLVDLILYFLIISHSYRLICKDQINRKELFFFGAYTLLTEIVLDFPFYLLYLDGLGIATFLFPLGLYSYFRWMKQY
ERDRGLFLSLLLSLLYESTHNFLSVTFSSITGDNFVLQYYGLFFFVVTVLTYFVTLKIIYYFHLELAYFDKDYLYPFLKK
VFFALLLLHIVSFVSDMVSTIKHLNSFGSILSSIVFISLLLTFFAMNSHKVQMEKEIALKQKKFEQKHLQNYTDEIVGLY
NEIRGFRHDYAGMLVSMQMAIDSGNLQEIDRVYNEVLVKANHKLRSDKYTYFDLNNIEDSALRSLVAQSIVYARNNGVEF
TLEVKDTITKLPIELLDLVRIMSVLLNNAVEGSADSYKKQMEVAVIKMETETVIVIQNSCKMTMTPSGDLFALGFSTKGR
NRGVGLNNVKELLDKYNNIILETEMEGSTFRQIIRFKRKFE

Nucleotide


Download         Length: 1326 bp        

>NTDB_id=336788 EQH44_RS10625 WP_025169508.1 2098955..2100280(-) (comD/comD1) [Streptococcus pneumoniae strain TVO_1902282]
ATGGATTTTTTCTTATTAGTAGATTTGATATTATATTTTTTAATTATTAGTCATAGTTACCGTTTAATTTGTAAAGATCA
AATAAATAGAAAAGAATTATTCTTTTTTGGTGCTTATACATTACTAACAGAAATAGTACTTGATTTTCCCTTCTATCTTC
TATATTTAGATGGGTTAGGGATTGCAACATTTTTATTTCCTTTGGGCCTATATTCCTATTTTCGATGGATGAAACAGTAT
GAGAGGGATAGAGGACTATTTCTAAGTTTACTACTATCTCTTTTATATGAGAGCACTCATAACTTTCTGTCCGTAACTTT
CTCTTCTATAACAGGAGACAATTTTGTTTTACAGTATTATGGCCTATTCTTTTTCGTTGTGACGGTGTTGACCTATTTTG
TTACATTAAAAATCATTTATTATTTCCATTTGGAACTAGCCTATTTTGACAAGGACTACCTTTATCCTTTCTTGAAAAAA
GTATTTTTTGCTTTACTATTGCTACATATTGTATCTTTCGTTTCAGATATGGTAAGTACGATTAAACATTTGAATAGTTT
TGGAAGTATTTTGTCATCTATTGTCTTTATCTCTCTCCTTTTGACCTTCTTTGCAATGAATTCTCATAAAGTTCAAATGG
AGAAAGAGATTGCTTTGAAGCAGAAGAAATTTGAACAGAAACATTTACAGAATTACACAGATGAAATTGTCGGTCTGTAT
AATGAAATCCGTGGTTTTCGACATGATTATGCTGGAATGCTTGTCAGCATGCAGATGGCAATTGACAGTGGTAATTTACA
GGAAATTGACAGAGTTTACAATGAAGTTTTGGTCAAAGCAAATCATAAACTACGTTCAGATAAGTACACTTACTTTGATT
TGAACAACATAGAAGATTCAGCTTTACGAAGTTTGGTTGCTCAGTCAATTGTCTATGCTCGAAATAATGGTGTAGAGTTT
ACACTGGAAGTAAAAGATACGATTACCAAGCTTCCAATTGAACTATTGGATTTAGTGCGTATCATGAGCGTTTTATTGAA
CAATGCTGTCGAAGGATCGGCTGATAGCTATAAAAAGCAGATGGAAGTAGCAGTTATTAAGATGGAAACTGAAACAGTTA
TTGTGATTCAGAATTCATGTAAAATGACGATGACTCCTTCAGGAGATCTATTTGCCTTAGGATTCTCCACTAAGGGAAGA
AATCGCGGAGTCGGATTAAATAATGTGAAAGAACTACTAGATAAGTACAACAACATTATTTTAGAAACAGAGATGGAAGG
CAGTACATTTAGACAAATCATTAGATTTAAGAGGAAATTTGAATGA

Domains

Predicted by InterproScan.

GHKL domain (HATPase_c_5)

(334-434)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comD/comD1 Streptococcus pneumoniae Rx1

94.785

100

0.948
  comD/comD1 Streptococcus pneumoniae D39

94.785

100

0.948
  comD/comD1 Streptococcus pneumoniae R6

94.785

100

0.948
  comD/comD2 Streptococcus pneumoniae TIGR4

94.331

100

0.943
  comD Streptococcus mitis SK321

91.837

100

0.918
  comD Streptococcus mitis NCTC 12261

86.621

100

0.866
  comD/comD1 Streptococcus gordonii str. Challis substr. CH1

49.733

84.807

0.422
  comD/comD2 Streptococcus gordonii strain NCTC7865

49.468

85.261

0.422

Multiple sequence alignment