Detailed information NTG0335622

Bioinformatically predicted

Overview

• Name: ciaR
• Type: Regulator
• Locus tag: FYA05_RS04820
• Genome accession: NZ_CP043211
• Coordinates: 1002151..1002810 (-)
• Length: 219 a.a.
• NCBI ID: WP_001221495.1
• Uniprot ID: P52076
• Organism: Escherichia coli O16:H48 strain PG20180050
• Function: repress competence development; post-transcriptional repression of CSP production (predicted from homology) Competence regulation

Genomic Context

Location: 997151..1007810

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
FYA05_RS04795 (FYA05_04795)	parE	997242..999134 (+)	1893	WP_000195296.1	DNA topoisomerase IV subunit B	-
FYA05_RS04800 (FYA05_04800)	ygiN	999182..999496 (-)	315	WP_000958598.1	putative quinol monooxygenase	-
FYA05_RS04805 (FYA05_04805)	mdaB	999527..1000108 (-)	582	WP_000065430.1	NADPH:quinone oxidoreductase MdaB	-
FYA05_RS04810 (FYA05_04810)	ygiZ	1000427..1000759 (+)	333	WP_000917684.1	DUF2645 family protein	-
FYA05_RS04815 (FYA05_04815)	qseC	1000805..1002154 (-)	1350	WP_000673402.1	quorum sensing histidine kinase QseC	-
FYA05_RS04820 (FYA05_04820)	ciaR	1002151..1002810 (-)	660	WP_001221495.1	quorum sensing response regulator transcription factor QseB	Regulator
FYA05_RS04825 (FYA05_04825)	ygiW	1002962..1003354 (+)	393	WP_000712658.1	OB fold stress tolerance protein YgiW	-
FYA05_RS04830 (FYA05_04830)	ygiV	1003407..1003889 (+)	483	WP_000183505.1	GyrI-like domain-containing protein	-
FYA05_RS04835 (FYA05_04835)	mqsR	1004094..1004390 (+)	297	WP_000415584.1	type II toxin-antitoxin system toxin MqsR	-
FYA05_RS04840 (FYA05_04840)	mqsA	1004392..1004787 (+)	396	WP_000650107.1	type II toxin-antitoxin system antitoxin MqsA	-
FYA05_RS04845 (FYA05_04845)	ygiS	1004920..1006527 (+)	1608	WP_001295629.1	ABC transporter substrate-binding protein	-

Sequence

Protein

• Length: 219 a.a.
• Molecular weight: 24677.59 Da
• Isoelectric Point: 6.9850

>NTDB_id=335622 FYA05_RS04820 WP_001221495.1 1002151..1002810(-) (ciaR) [Escherichia coli O16:H48 strain PG20180050]
MRILLIEDDMLIGDGIKTGLSKMGFSVDWFTQGRQGKEALYSAPYDAVILDLTLPGMDGRDILREWREKGQREPVLILTA
RDALAERVEGLRLGADDYLCKPFALIEVAARLEALMRRTNGQASNELRHGNVMLDPGKRIATLAGEPLTLKPKEFALLEL
LMRNAGRVLSRKLIEEKLYTWDEEVTSNAVEVHVHHLRRKLGSDFIRTVHGIGYTLGEK

Nucleotide

• Length: 660 bp

>NTDB_id=335622 FYA05_RS04820 WP_001221495.1 1002151..1002810(-) (ciaR) [Escherichia coli O16:H48 strain PG20180050]
ATGCGAATTTTACTGATAGAAGATGACATGCTGATTGGCGACGGCATCAAAACGGGCCTTAGTAAAATGGGTTTTAGCGT
CGACTGGTTTACACAAGGTCGTCAGGGAAAAGAGGCGCTTTATAGCGCACCTTATGATGCGGTGATCCTGGATTTAACCT
TACCAGGCATGGATGGTCGCGATATTTTGCGCGAATGGCGAGAAAAAGGTCAGCGTGAGCCGGTACTGATCCTGACCGCG
CGCGATGCGCTGGCGGAACGTGTAGAAGGGCTGCGTCTGGGAGCTGACGATTATCTGTGTAAACCTTTTGCGTTGATAGA
AGTCGCCGCCAGGCTGGAAGCTCTGATGCGCCGAACCAACGGCCAGGCCAGCAACGAGCTGCGCCACGGTAACGTCATGC
TCGACCCCGGCAAACGTATCGCCACGCTGGCTGGCGAACCCTTAACACTGAAACCAAAAGAATTTGCCCTGCTGGAATTA
CTGATGCGTAACGCTGGTCGGGTACTGTCGCGCAAACTGATTGAAGAGAAACTGTATACCTGGGACGAAGAGGTCACCAG
TAATGCCGTTGAAGTGCATGTGCATCATCTGCGACGCAAACTCGGTAGTGATTTTATTCGTACCGTGCATGGTATTGGTT
ACACATTAGGTGAGAAATGA

Domains

Predicted by InterProScan.

• Response regulator receiver domain (Response_reg) (3-112)

• Transcriptional regulatory protein, C terminal (Trans_reg_C) (145-216)

3D structure

• AlphaFold DB: P52076

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
ciaR	Streptococcus pneumoniae Rx1	37.885	100	0.393
ciaR	Streptococcus pneumoniae D39	37.885	100	0.393
ciaR	Streptococcus pneumoniae R6	37.885	100	0.393
ciaR	Streptococcus pneumoniae TIGR4	37.885	100	0.393
ciaR	Streptococcus mutans UA159	35.426	100	0.361