Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaR   Type   Regulator
Locus tag   FYA11_RS20505 Genome accession   NZ_CP043199
Coordinates   4212083..4212742 (+) Length   219 a.a.
NCBI ID   WP_001221495.1    Uniprot ID   P52076
Organism   Escherichia coli O16:H48 strain PG20180060     
Function   repress competence development; post-transcriptional repression of CSP production (predicted from homology)   
Competence regulation

Genomic Context

Location: 4207083..4217742
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  FYA11_RS20480 (FYA11_20480) ygiS 4208366..4209973 (-) 1608 WP_001295629.1 ABC transporter substrate-binding protein -
  FYA11_RS20485 (FYA11_20485) mqsA 4210106..4210501 (-) 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA -
  FYA11_RS20490 (FYA11_20490) mqsR 4210503..4210799 (-) 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR -
  FYA11_RS20495 (FYA11_20495) ygiV 4211004..4211486 (-) 483 WP_000183505.1 GyrI-like domain-containing protein -
  FYA11_RS20500 (FYA11_20500) ygiW 4211539..4211931 (-) 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
  FYA11_RS20505 (FYA11_20505) ciaR 4212083..4212742 (+) 660 WP_001221495.1 quorum sensing response regulator transcription factor QseB Regulator
  FYA11_RS20510 (FYA11_20510) qseC 4212739..4214088 (+) 1350 WP_000673402.1 quorum sensing histidine kinase QseC -
  FYA11_RS20515 (FYA11_20515) ygiZ 4214134..4214466 (-) 333 WP_000917684.1 DUF2645 family protein -
  FYA11_RS20520 (FYA11_20520) mdaB 4214785..4215366 (+) 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
  FYA11_RS20525 (FYA11_20525) ygiN 4215397..4215711 (+) 315 WP_000958598.1 putative quinol monooxygenase -
  FYA11_RS20530 (FYA11_20530) parE 4215759..4217651 (-) 1893 WP_000195296.1 DNA topoisomerase IV subunit B -

Sequence

Protein


Download         Length: 219 a.a.        Molecular weight: 24677.59 Da        Isoelectric Point: 6.9850

>NTDB_id=335186 FYA11_RS20505 WP_001221495.1 4212083..4212742(+) (ciaR) [Escherichia coli O16:H48 strain PG20180060]
MRILLIEDDMLIGDGIKTGLSKMGFSVDWFTQGRQGKEALYSAPYDAVILDLTLPGMDGRDILREWREKGQREPVLILTA
RDALAERVEGLRLGADDYLCKPFALIEVAARLEALMRRTNGQASNELRHGNVMLDPGKRIATLAGEPLTLKPKEFALLEL
LMRNAGRVLSRKLIEEKLYTWDEEVTSNAVEVHVHHLRRKLGSDFIRTVHGIGYTLGEK

Nucleotide


Download         Length: 660 bp        

>NTDB_id=335186 FYA11_RS20505 WP_001221495.1 4212083..4212742(+) (ciaR) [Escherichia coli O16:H48 strain PG20180060]
ATGCGAATTTTACTGATAGAAGATGACATGCTGATTGGCGACGGCATCAAAACGGGCCTTAGTAAAATGGGTTTTAGCGT
CGACTGGTTTACACAAGGTCGTCAGGGAAAAGAGGCGCTTTATAGCGCACCTTATGATGCGGTGATCCTGGATTTAACCT
TACCAGGCATGGATGGTCGCGATATTTTGCGCGAATGGCGAGAAAAAGGTCAGCGTGAGCCGGTACTGATCCTGACCGCG
CGCGATGCGCTGGCGGAACGTGTAGAAGGGCTGCGTCTGGGAGCTGACGATTATCTGTGTAAACCTTTTGCGTTGATAGA
AGTCGCCGCCAGGCTGGAAGCTCTGATGCGCCGAACCAACGGCCAGGCCAGCAACGAGCTGCGCCACGGTAACGTCATGC
TCGACCCCGGCAAACGTATCGCCACGCTGGCTGGCGAACCCTTAACACTGAAACCAAAAGAATTTGCCCTGCTGGAATTA
CTGATGCGTAACGCTGGTCGGGTACTGTCGCGCAAACTGATTGAAGAGAAACTGTATACCTGGGACGAAGAGGTCACCAG
TAATGCCGTTGAAGTGCATGTGCATCATCTGCGACGCAAACTCGGTAGTGATTTTATTCGTACCGTGCATGGTATTGGTT
ACACATTAGGTGAGAAATGA

Domains

Predicted by InterProScan.

Response regulator receiver domain (Response_reg)

(3-112)

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(145-216)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB P52076

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaR Streptococcus pneumoniae Rx1

37.885

100

0.393
  ciaR Streptococcus pneumoniae D39

37.885

100

0.393
  ciaR Streptococcus pneumoniae R6

37.885

100

0.393
  ciaR Streptococcus pneumoniae TIGR4

37.885

100

0.393
  ciaR Streptococcus mutans UA159

35.426

100

0.361