Detailed information    

insolico Bioinformatically predicted

Overview

Name   letA   Type   Regulator
Locus tag   FYA18_RS12535 Genome accession   NZ_CP043185
Coordinates   2580673..2581263 (-) Length   196 a.a.
NCBI ID   WP_000633668.1    Uniprot ID   P0AGA7
Organism   Escherichia coli O16:H48 strain PG20180171     
Function   regulate competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 2575673..2586263
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  FYA18_RS12520 (FYA18_12520) uhpT 2576313..2577704 (-) 1392 WP_000879194.1 hexose-6-phosphate:phosphate antiporter -
  FYA18_RS12525 (FYA18_12525) uhpC 2577842..2579161 (-) 1320 WP_000936566.1 MFS transporter family glucose-6-phosphate receptor UhpC -
  FYA18_RS12530 (FYA18_12530) uhpB 2579171..2580673 (-) 1503 WP_001295243.1 signal transduction histidine-protein kinase/phosphatase UhpB -
  FYA18_RS12535 (FYA18_12535) letA 2580673..2581263 (-) 591 WP_000633668.1 transcriptional regulator UhpA Regulator
  FYA18_RS12540 (FYA18_12540) ilvN 2581339..2581629 (-) 291 WP_001181706.1 acetolactate synthase small subunit -
  FYA18_RS12545 (FYA18_12545) ilvB 2581633..2583321 (-) 1689 WP_000168475.1 acetolactate synthase large subunit -
  FYA18_RS12550 (FYA18_12550) ivbL 2583427..2583525 (-) 99 WP_001300753.1 ilvB operon leader peptide IvbL -
  FYA18_RS12555 (FYA18_12555) tisB 2584090..2584179 (+) 90 WP_001054909.1 type I toxin-antitoxin system toxin TisB -
  FYA18_RS22815 ysdE 2584303..2584377 (-) 75 WP_211180519.1 protein YsdE -
  FYA18_RS12560 (FYA18_12560) emrD 2584459..2585643 (+) 1185 WP_000828746.1 multidrug efflux MFS transporter EmrD -
  FYA18_RS12565 (FYA18_12565) yidF 2585651..2586148 (-) 498 WP_000148061.1 radical SAM protein -

Sequence

Protein


Download         Length: 196 a.a.        Molecular weight: 20889.30 Da        Isoelectric Point: 5.9982

>NTDB_id=334594 FYA18_RS12535 WP_000633668.1 2580673..2581263(-) (letA) [Escherichia coli O16:H48 strain PG20180171]
MITVALIDDHLIVRSGFAQLLGLEPDLQVVAEFGSGREALAGLPGRGVQVCICDISMPDISGLELLSQLPKGMATIMLSV
HDSPALVEQALNAGARGFLSKRCSPDELIAAVHTVATGGCYLTPDIAIKLASGRQDPLTKRERQVAEKLAQGMAVKEIAA
ELGLSPKTVHVHRANLMEKLGVSNDVELARRMFDGW

Nucleotide


Download         Length: 591 bp        

>NTDB_id=334594 FYA18_RS12535 WP_000633668.1 2580673..2581263(-) (letA) [Escherichia coli O16:H48 strain PG20180171]
ATGATCACCGTTGCCCTTATAGACGATCACCTCATCGTCCGCTCCGGCTTTGCGCAGCTGCTGGGGCTGGAACCTGATTT
GCAGGTAGTTGCCGAGTTTGGTTCGGGGCGCGAGGCGCTGGCGGGGCTGCCGGGGCGCGGTGTGCAGGTGTGTATTTGCG
ATATCTCCATGCCCGATATCTCCGGTCTGGAGCTGCTAAGCCAGCTGCCGAAAGGTATGGCGACGATTATGCTCTCCGTT
CACGACAGTCCTGCGCTGGTTGAGCAGGCGCTTAACGCGGGGGCACGCGGCTTTCTTTCCAAACGCTGTAGCCCGGATGA
ACTCATTGCTGCGGTGCATACGGTTGCCACGGGCGGCTGTTATCTGACGCCGGATATTGCCATTAAACTGGCATCCGGTC
GTCAGGACCCGCTAACCAAACGTGAACGCCAGGTGGCGGAAAAACTGGCGCAAGGAATGGCGGTGAAAGAGATTGCCGCC
GAACTGGGCTTGTCACCGAAAACGGTACACGTCCATCGCGCCAATCTGATGGAAAAACTGGGCGTCAGTAACGACGTAGA
GCTGGCGCGCCGCATGTTTGATGGCTGGTGA

Domains

Predicted by InterProScan.

Bacterial regulatory proteins, luxR family (GerE)

(136-191)

Response regulator receiver domain (Response_reg)

(4-112)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB P0AGA7

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  letA Legionella pneumophila str. Paris

38.5

100

0.393
  letA Legionella pneumophila strain ERS1305867

38.5

100

0.393
  degU Bacillus subtilis subsp. subtilis str. 168

33.184

100

0.378