Detailed information NTG0332379

Bioinformatically predicted

Overview

• Name: ciaR
• Type: Regulator
• Locus tag: BAA196FS_RS03475
• Genome accession: NZ_CP042867
• Coordinates: 714641..715300 (-)
• Length: 219 a.a.
• NCBI ID: WP_001221495.1
• Uniprot ID: P52076
• Organism: Escherichia coli strain ATCC BAA-196
• Function: repress competence development; post-transcriptional repression of CSP production (predicted from homology) Competence regulation

Genomic Context

Location: 709641..720300

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
BAA196FS_RS03450 (BAA196FS_0678)	parE	709732..711624 (+)	1893	WP_000195296.1	DNA topoisomerase IV subunit B	-
BAA196FS_RS03455 (BAA196FS_0679)	ygiN	711672..711986 (-)	315	WP_000958598.1	putative quinol monooxygenase	-
BAA196FS_RS03460 (BAA196FS_0680)	mdaB	712017..712598 (-)	582	WP_000065430.1	NADPH:quinone oxidoreductase MdaB	-
BAA196FS_RS03465	ygiZ	712917..713249 (+)	333	WP_000917684.1	DUF2645 family protein	-
BAA196FS_RS03470 (BAA196FS_0681)	qseC	713295..714644 (-)	1350	WP_000673402.1	quorum sensing histidine kinase QseC	-
BAA196FS_RS03475 (BAA196FS_0682)	ciaR	714641..715300 (-)	660	WP_001221495.1	quorum sensing response regulator transcription factor QseB	Regulator
BAA196FS_RS03480 (BAA196FS_0683)	ygiW	715452..715844 (+)	393	WP_000712658.1	OB fold stress tolerance protein YgiW	-
BAA196FS_RS03485 (BAA196FS_0684)	ygiV	715897..716379 (+)	483	WP_000183505.1	GyrI-like domain-containing protein	-
BAA196FS_RS03490 (BAA196FS_0685)	mqsR	716584..716880 (+)	297	WP_000415584.1	type II toxin-antitoxin system toxin MqsR	-
BAA196FS_RS03495 (BAA196FS_0686)	mqsA	716882..717277 (+)	396	WP_000650107.1	type II toxin-antitoxin system antitoxin MqsA	-
BAA196FS_RS03500 (BAA196FS_0687)	ygiS	717410..719017 (+)	1608	WP_001295629.1	ABC transporter substrate-binding protein	-

Sequence

Protein

• Length: 219 a.a.
• Molecular weight: 24677.59 Da
• Isoelectric Point: 6.9850

>NTDB_id=332379 BAA196FS_RS03475 WP_001221495.1 714641..715300(-) (ciaR) [Escherichia coli strain ATCC BAA-196]
MRILLIEDDMLIGDGIKTGLSKMGFSVDWFTQGRQGKEALYSAPYDAVILDLTLPGMDGRDILREWREKGQREPVLILTA
RDALAERVEGLRLGADDYLCKPFALIEVAARLEALMRRTNGQASNELRHGNVMLDPGKRIATLAGEPLTLKPKEFALLEL
LMRNAGRVLSRKLIEEKLYTWDEEVTSNAVEVHVHHLRRKLGSDFIRTVHGIGYTLGEK

Nucleotide

• Length: 660 bp

>NTDB_id=332379 BAA196FS_RS03475 WP_001221495.1 714641..715300(-) (ciaR) [Escherichia coli strain ATCC BAA-196]
ATGCGAATTTTACTGATAGAAGATGACATGCTGATTGGCGACGGCATCAAAACGGGCCTTAGTAAAATGGGTTTTAGCGT
CGACTGGTTTACACAAGGTCGTCAGGGAAAAGAGGCGCTTTATAGCGCACCTTATGATGCGGTGATCCTGGATTTAACCT
TACCAGGCATGGATGGTCGCGATATTTTGCGCGAATGGCGAGAAAAAGGTCAGCGTGAGCCGGTACTGATCCTGACCGCG
CGCGATGCGCTGGCGGAACGTGTAGAAGGGCTGCGTCTGGGAGCTGACGATTATCTGTGTAAACCTTTTGCGTTGATAGA
AGTCGCCGCCAGGCTGGAAGCTCTGATGCGCCGAACCAACGGCCAGGCCAGCAACGAGCTGCGCCACGGTAACGTCATGC
TCGACCCCGGCAAACGTATCGCCACGCTGGCTGGCGAACCCTTAACACTGAAACCAAAAGAATTTGCCCTGCTGGAATTA
CTGATGCGTAACGCTGGTCGGGTACTGTCGCGCAAACTGATTGAAGAGAAACTGTATACCTGGGACGAAGAGGTCACCAG
TAATGCCGTTGAAGTGCATGTGCATCATCTGCGACGCAAACTCGGTAGTGATTTTATTCGTACCGTGCATGGTATTGGTT
ACACATTAGGTGAGAAATGA

Domains

Predicted by InterProScan.

• Response regulator receiver domain (Response_reg) (3-112)

• Transcriptional regulatory protein, C terminal (Trans_reg_C) (145-216)

3D structure

• AlphaFold DB: P52076

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
ciaR	Streptococcus pneumoniae Rx1	37.885	100	0.393
ciaR	Streptococcus pneumoniae D39	37.885	100	0.393
ciaR	Streptococcus pneumoniae R6	37.885	100	0.393
ciaR	Streptococcus pneumoniae TIGR4	37.885	100	0.393
ciaR	Streptococcus mutans UA159	35.426	100	0.361