Detailed information    

insolico Bioinformatically predicted

Overview

Name   comE/blpR   Type   Regulator
Locus tag   SPP_RS02695 Genome accession   NC_012467
Coordinates   498007..498744 (+) Length   245 a.a.
NCBI ID   WP_001219137.1    Uniprot ID   -
Organism   Streptococcus pneumoniae P1031     
Function   activate transcription of early competence genes; regulation of comX expression (predicted from homology)   
Competence regulation

Genomic Context

Location: 493007..503744
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  SPP_RS13030 (SPP_0541) - 493802..494176 (-) 375 WP_001845059.1 hypothetical protein -
  SPP_RS02665 (SPP_0542) - 494338..494625 (-) 288 WP_000777760.1 hypothetical protein -
  SPP_RS02670 (SPP_0543) - 494635..495045 (-) 411 WP_001278301.1 HIT family protein -
  SPP_RS02675 (SPP_0544) pptA 495113..495844 (+) 732 WP_000889923.1 ABC transporter ATP-binding protein Regulator
  SPP_RS02680 (SPP_0545) - 495841..496890 (+) 1050 WP_000653769.1 ABC transporter permease -
  SPP_RS02685 (SPP_0546) - 497058..497387 (-) 330 WP_000132583.1 hypothetical protein -
  SPP_RS02690 (SPP_0547) - 497664..498002 (+) 339 WP_000682136.1 LytTR family DNA-binding domain-containing protein -
  SPP_RS02695 (SPP_0548) comE/blpR 498007..498744 (+) 738 WP_001219137.1 LytTR family DNA-binding domain-containing protein Regulator
  SPP_RS02700 (SPP_0549) - 498758..500098 (+) 1341 WP_001099894.1 sensor histidine kinase -
  SPP_RS02705 (SPP_0550) blpC 500142..500297 (-) 156 WP_000358812.1 quorum-sensing system pheromone BlpC -
  SPP_RS02710 (SPP_0551) - 500354..501715 (-) 1362 WP_001069063.1 bacteriocin secretion accessory protein -

Sequence

Protein


Download         Length: 245 a.a.        Molecular weight: 28768.92 Da        Isoelectric Point: 6.2366

>NTDB_id=33216 SPP_RS02695 WP_001219137.1 498007..498744(+) (comE/blpR) [Streptococcus pneumoniae P1031]
MRIFVLEDDFSQQTRIETTIEKLLKEHHITLSSFEVFGKPDQLLAEVHEKGAHQLFFLDIEIRNEEMKGLEVARKIRDRD
PYALIVFVTTHSEFMPLSFRYQVSALDYIDKALSAEEFESRIETALLYANGQDSKSLAEDCFYFKSKFAQFQYPFKEVYY
LETSTRPHRVILYTKTDRLEFTASLEEVLKQEPRLLQCHRSFLINPANVVHLDKKEKLLFFPNGGSCLIARYKVREVSEA
INNLH

Nucleotide


Download         Length: 738 bp        

>NTDB_id=33216 SPP_RS02695 WP_001219137.1 498007..498744(+) (comE/blpR) [Streptococcus pneumoniae P1031]
ATGAGAATATTTGTTTTAGAAGATGATTTTTCCCAACAGACTAGAATTGAAACGACGATTGAGAAACTCTTGAAGGAACA
TCATATCACTCTGAGTTCTTTTGAAGTTTTTGGTAAGCCAGATCAATTGCTGGCAGAGGTGCATGAGAAGGGGGCCCATC
AGCTATTCTTTTTGGATATTGAGATTCGAAATGAGGAGATGAAGGGTCTGGAAGTGGCTAGAAAGATTCGGGATCGGGAT
CCGTATGCCCTGATTGTCTTTGTGACGACTCACTCGGAGTTTATGCCCCTGTCCTTTCGCTACCAAGTGTCTGCTCTGGA
TTATATTGATAAGGCCCTTTCGGCAGAGGAGTTTGAATCTCGTATCGAGACAGCCCTCCTCTATGCCAATGGTCAAGACA
GTAAAAGTCTAGCGGAAGATTGCTTTTACTTTAAATCAAAATTTGCTCAATTCCAGTATCCTTTTAAAGAGGTTTACTAT
CTCGAAACGTCCACAAGACCCCATCGTGTTATTCTCTATACCAAGACAGACAGGCTGGAATTTACAGCGAGTCTAGAGGA
GGTTCTCAAGCAGGAGCCTCGTCTCTTGCAGTGCCATCGCTCTTTTCTCATCAATCCTGCCAATGTGGTGCATTTAGATA
AGAAAGAAAAACTGCTTTTCTTTCCCAATGGTGGAAGTTGTCTAATCGCGCGTTATAAGGTCAGGGAAGTGTCTGAGGCT
ATTAATAACTTACACTGA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(3-122)

LytTr DNA-binding domain (LytTR)

(151-241)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comE/blpR Streptococcus mutans UA159

53.441

100

0.539
  comE/comE1 Streptococcus equinus JB1

43.038

96.735

0.416
  comE/comE2 Streptococcus equinus JB1

38.43

98.776

0.38

Multiple sequence alignment