Detailed information NTG0329154

Bioinformatically predicted

Overview

• Name: agrA
• Type: Regulator
• Locus tag: EH163_RS07870
• Genome accession: NZ_CP034115
• Coordinates: 1564653..1565369 (-)
• Length: 238 a.a.
• NCBI ID: WP_001829999.1
• Uniprot ID: C0LF82
• Organism: Staphylococcus epidermidis strain CDC121
• Function: promote expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1559653..1570369

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
EH163_RS07850	-	1560934..1561887 (+)	954	WP_124743127.1	LacI family DNA-binding transcriptional regulator	-
EH163_RS07860	-	1562147..1563619 (+)	1473	WP_001830011.1	sucrose-6-phosphate hydrolase	-
EH163_RS07865	-	1563626..1564585 (+)	960	WP_001830023.1	carbohydrate kinase	-
EH163_RS07870	agrA	1564653..1565369 (-)	717	WP_001829999.1	LytTR family DNA-binding domain-containing protein	Regulator
EH163_RS07875	-	1565386..1566675 (-)	1290	WP_002440376.1	GHKL domain-containing protein	-
EH163_RS07880	-	1566702..1566842 (-)	141	WP_001830021.1	cyclic lactone autoinducer peptide	-
EH163_RS07885	-	1566826..1567410 (-)	585	WP_001830005.1	accessory gene regulator B family protein	-
EH163_RS07890	hld	1567728..1567805 (+)	78	WP_002494082.1	delta-hemolysin	-
EH163_RS07895	-	1568186..1568971 (-)	786	WP_001830000.1	carbon-nitrogen family hydrolase	-

Sequence

Protein

• Length: 238 a.a.
• Molecular weight: 27936.97 Da
• Isoelectric Point: 5.6250

>NTDB_id=329154 EH163_RS07870 WP_001829999.1 1564653..1565369(-) (agrA) [Staphylococcus epidermidis strain CDC121]
MKIFVCEDDQRQREHMVSIIKNYIMIEEKPMELALATNDPYEVLEQSKELNDIGCYFLDIQLEADMNGIKLASEIRKHDP
VGNIIFVTSHSELTYLTFVYKVAAMDFIFKDDPSELKMRIIDCLETAHTRLKLLSKESNVDTIELKRGSNSVYVQYDDIM
FFESSTKSHRLIAHLDNRQIEFYGNLKELAQLDERFFRCHNSFVINRHNIESIDSKERIVYFKNGENCFASVRNVKKI

Nucleotide

• Length: 717 bp

>NTDB_id=329154 EH163_RS07870 WP_001829999.1 1564653..1565369(-) (agrA) [Staphylococcus epidermidis strain CDC121]
ATGAAAATTTTTGTTTGTGAAGATGACCAAAGACAAAGAGAACATATGGTATCAATCATTAAAAACTACATAATGATTGA
AGAAAAGCCAATGGAGTTAGCCTTAGCAACAAATGATCCTTATGAGGTCTTAGAGCAATCAAAAGAACTTAATGACATTG
GTTGTTACTTCCTTGATATTCAATTAGAAGCTGATATGAACGGTATTAAATTAGCCAGTGAAATTCGTAAACATGATCCT
GTTGGTAATATTATATTTGTAACCAGTCACAGTGAACTGACTTATTTGACGTTTGTTTATAAAGTGGCTGCTATGGATTT
TATTTTTAAGGATGATCCATCTGAATTAAAAATGAGAATCATAGATTGTCTTGAAACAGCACATACACGACTCAAATTAT
TATCAAAAGAAAGTAATGTAGATACGATTGAGTTAAAGCGGGGAAGTAATTCAGTATACGTTCAATATGATGACATTATG
TTTTTTGAATCATCTACGAAATCTCATAGACTCATCGCACATCTTGATAATCGACAAATTGAATTTTATGGAAATTTAAA
GGAATTAGCACAGCTTGATGAACGTTTCTTTAGATGTCATAACAGTTTTGTGATAAACAGGCATAATATTGAATCTATTG
ATTCAAAAGAACGTATTGTTTACTTTAAGAATGGCGAAAATTGTTTCGCTTCAGTACGTAATGTTAAAAAAATATAA

Domains

Predicted by InterproScan.

• LytTr DNA-binding domain (LytTR) (151-237)

• Response regulator receiver domain (Response_reg) (3-120)

3D structure

• AlphaFold DB: C0LF82

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
agrA	Staphylococcus aureus N315	87.815	100	0.878
comE/comE2	Streptococcus gordonii strain NCTC7865	35.178	100	0.374
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	35.178	100	0.374