Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaH   Type   Regulator
Locus tag   EGX82_RS00370 Genome accession   NZ_CP033822
Coordinates   73419..74732 (+) Length   437 a.a.
NCBI ID   WP_000042576.1    Uniprot ID   -
Organism   Streptococcus agalactiae strain FDAARGOS_512     
Function   Required for optimal comC expression (predicted from homology)   
Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
ICE 75064..141507 73419..74732 flank 332


Gene organization within MGE regions


Location: 73419..141507
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  EGX82_RS00370 (EGX82_00370) ciaH 73419..74732 (+) 1314 WP_000042576.1 HAMP domain-containing sensor histidine kinase Regulator
  EGX82_RS00375 (EGX82_00375) - 74821..75153 (+) 333 WP_000402075.1 putative DNA-binding protein -
  EGX82_RS00380 (EGX82_00380) ffh 75171..76736 (+) 1566 WP_000863589.1 signal recognition particle protein -
  EGX82_RS00385 (EGX82_00385) - 76803..77489 (+) 687 WP_000280305.1 SatD family protein -
  EGX82_RS00390 (EGX82_00390) - 77479..78252 (+) 774 WP_000622398.1 DUF3307 domain-containing protein -
  EGX82_RS00395 (EGX82_00395) - 78285..79879 (-) 1595 Protein_76 peptide ABC transporter substrate-binding protein -
  EGX82_RS00400 (EGX82_00400) - 80307..81329 (+) 1023 WP_025197144.1 hypothetical protein -
  EGX82_RS00405 (EGX82_00405) - 81316..82797 (+) 1482 WP_025197145.1 LA2681 family HEPN domain-containing protein -
  EGX82_RS00410 (EGX82_00410) - 83173..83790 (+) 618 WP_025197146.1 TetR/AcrR family transcriptional regulator -
  EGX82_RS00415 (EGX82_00415) - 83900..84610 (+) 711 WP_025197147.1 ABC transporter ATP-binding protein -
  EGX82_RS00420 (EGX82_00420) - 84603..86162 (+) 1560 WP_025197148.1 membrane protein -
  EGX82_RS00425 (EGX82_00425) - 86181..86402 (+) 222 WP_025197149.1 DUF1648 domain-containing protein -
  EGX82_RS00430 (EGX82_00430) - 86399..86740 (+) 342 WP_025197150.1 GntR family transcriptional regulator -
  EGX82_RS00435 (EGX82_00435) - 86897..87532 (+) 636 WP_025197151.1 TetR/AcrR family transcriptional regulator -
  EGX82_RS00440 (EGX82_00440) - 87804..88544 (+) 741 WP_025197152.1 ABC transporter permease -
  EGX82_RS00445 (EGX82_00445) - 88680..89417 (+) 738 WP_025197153.1 ATP-binding cassette domain-containing protein -
  EGX82_RS00450 (EGX82_00450) - 89420..91102 (+) 1683 WP_000811441.1 ABC transporter ATP-binding protein -
  EGX82_RS00455 (EGX82_00455) - 91731..91901 (+) 171 WP_000873143.1 hypothetical protein -
  EGX82_RS00460 (EGX82_00460) mef(A) 92287..93504 (+) 1218 WP_000417519.1 macrolide efflux MFS transporter Mef(A) -
  EGX82_RS00465 (EGX82_00465) msr(D) 93624..95087 (+) 1464 WP_000420313.1 ABC-F type ribosomal protection protein Msr(D) -
  EGX82_RS00470 (EGX82_00470) - 95205..95504 (-) 300 WP_001072467.1 DUF5960 family protein -
  EGX82_RS00475 (EGX82_00475) - 95491..95859 (-) 369 WP_000567222.1 hypothetical protein -
  EGX82_RS00480 (EGX82_00480) - 95872..96207 (-) 336 WP_000806926.1 hypothetical protein -
  EGX82_RS00485 (EGX82_00485) - 96204..96449 (-) 246 WP_001813542.1 hypothetical protein -
  EGX82_RS00500 (EGX82_00500) - 97350..98618 (+) 1269 WP_025197154.1 site-specific integrase -
  EGX82_RS00505 (EGX82_00505) - 98622..100472 (+) 1851 WP_025197155.1 hypothetical protein -
  EGX82_RS00510 (EGX82_00510) - 100469..102139 (+) 1671 WP_006151537.1 hypothetical protein -
  EGX82_RS00515 (EGX82_00515) - 102132..102845 (+) 714 WP_006151858.1 hypothetical protein -
  EGX82_RS00520 (EGX82_00520) - 102854..104701 (+) 1848 WP_025197156.1 zinc-ribbon domain-containing protein -
  EGX82_RS00525 (EGX82_00525) xerS 104979..106049 (+) 1071 WP_000817930.1 tyrosine recombinase XerS -
  EGX82_RS00530 (EGX82_00530) - 106092..107030 (-) 939 WP_000620981.1 sensor histidine kinase -
  EGX82_RS00535 (EGX82_00535) - 107027..107695 (-) 669 WP_000076874.1 response regulator transcription factor -
  EGX82_RS00540 (EGX82_00540) - 107805..109760 (-) 1956 WP_025197157.1 FtsX-like permease family protein -
  EGX82_RS00545 (EGX82_00545) - 109762..110514 (-) 753 WP_000923535.1 ABC transporter ATP-binding protein -
  EGX82_RS00550 (EGX82_00550) - 110540..111502 (-) 963 WP_001253125.1 S41 family peptidase -
  EGX82_RS00555 (EGX82_00555) - 111668..112206 (+) 539 Protein_106 PASTA domain-containing protein -
  EGX82_RS00560 (EGX82_00560) - 112186..113034 (-) 849 WP_000694285.1 MetQ/NlpA family ABC transporter substrate-binding protein -
  EGX82_RS00565 (EGX82_00565) - 113167..113910 (-) 744 WP_000559005.1 GNAT family N-acetyltransferase -
  EGX82_RS00570 (EGX82_00570) trmFO 113988..115322 (-) 1335 WP_000083753.1 methylenetetrahydrofolate--tRNA-(uracil(54)- C(5))-methyltransferase (FADH(2)-oxidizing) TrmFO -
  EGX82_RS00575 (EGX82_00575) - 115436..116134 (-) 699 WP_000936161.1 GntR family transcriptional regulator -
  EGX82_RS00580 (EGX82_00580) guaA 116347..117909 (+) 1563 WP_000129872.1 glutamine-hydrolyzing GMP synthase -
  EGX82_RS00585 (EGX82_00585) - 117977..119170 (-) 1194 WP_000237798.1 site-specific integrase -
  EGX82_RS00590 (EGX82_00590) - 119197..119397 (-) 201 WP_000633909.1 DUF3173 domain-containing protein -
  EGX82_RS00600 (EGX82_00600) - 119893..120123 (-) 231 WP_000845144.1 helix-turn-helix domain-containing protein -
  EGX82_RS00605 (EGX82_00605) - 120120..120542 (-) 423 WP_000804878.1 sigma-70 family RNA polymerase sigma factor -
  EGX82_RS00610 (EGX82_00610) - 121074..121427 (+) 354 WP_001227349.1 helix-turn-helix transcriptional regulator -
  EGX82_RS00615 (EGX82_00615) - 121485..121673 (-) 189 WP_032506803.1 cysteine-rich KTR domain-containing protein -
  EGX82_RS00620 (EGX82_00620) tet(M) 121771..123690 (-) 1920 WP_000691737.1 tetracycline resistance ribosomal protection protein Tet(M) -
  EGX82_RS11410 - 123706..123753 (-) 48 Protein_119 hypothetical protein -
  EGX82_RS00635 (EGX82_00635) - 124067..124996 (-) 930 WP_000584387.1 conjugal transfer protein -
  EGX82_RS00640 (EGX82_00640) - 125013..126035 (-) 1023 WP_000768374.1 bifunctional lytic transglycosylase/C40 family peptidase -
  EGX82_RS00645 (EGX82_00645) - 126032..128059 (-) 2028 WP_000192390.1 CD3337/EF1877 family mobilome membrane protein -
  EGX82_RS00650 (EGX82_00650) - 128056..130509 (-) 2454 WP_000941001.1 ATP-binding protein -
  EGX82_RS00655 (EGX82_00655) - 130493..130888 (-) 396 WP_000723886.1 conjugal transfer protein -
  EGX82_RS00660 (EGX82_00660) - 130959..131984 (-) 1026 WP_000234705.1 hypothetical protein -
  EGX82_RS00665 (EGX82_00665) - 132063..133229 (-) 1167 WP_000195404.1 IS256 family transposase -
  EGX82_RS00670 (EGX82_00670) - 133392..133892 (-) 501 WP_000421245.1 antirestriction protein ArdA -
  EGX82_RS00675 (EGX82_00675) - 133954..134733 (-) 780 WP_000678782.1 abortive infection family protein -
  EGX82_RS00680 (EGX82_00680) - 134775..134996 (-) 222 WP_001009054.1 hypothetical protein -
  EGX82_RS00685 (EGX82_00685) - 134993..135265 (-) 273 WP_000055367.1 hypothetical protein -
  EGX82_RS00690 (EGX82_00690) mobT 135262..136446 (-) 1185 WP_000426691.1 MobT family relaxase -
  EGX82_RS00695 (EGX82_00695) - 136628..138031 (-) 1404 WP_123922111.1 FtsK/SpoIIIE domain-containing protein -
  EGX82_RS00700 (EGX82_00700) - 138053..138826 (-) 774 WP_000185760.1 hypothetical protein -
  EGX82_RS00705 (EGX82_00705) - 138836..139213 (-) 378 WP_001234189.1 YdcP family protein -
  EGX82_RS00710 (EGX82_00710) - 139234..139548 (-) 315 WP_000421280.1 YdcP family protein -
  EGX82_RS00715 (EGX82_00715) - 140125..141252 (+) 1128 WP_000547446.1 cation:proton antiporter -

Sequence

Protein


Download         Length: 437 a.a.        Molecular weight: 49678.12 Da        Isoelectric Point: 9.4961

>NTDB_id=326094 EGX82_RS00370 WP_000042576.1 73419..74732(+) (ciaH) [Streptococcus agalactiae strain FDAARGOS_512]
MSKPIKISKFKKNVSDSHFIHFFTVFSGIFLVMTVIILQVMRYGVYSSVDSSLKYISTHPKNYINMVMSRTAAYLDNSNI
ASVKLKPGGQTVANTDIILFTSEEEVINYFDAFSNYQFLKPNKKNLGGISELTLTNIFGQDETYHAVTVKVNNPAYPNVT
YMTAIVNIDQLVNAKERYEKIIIFVMTTFWIISIGASIYLAKWAQKPIIENYERQKAFVENASHELRTPLAVLQNRLETL
FRKPNATILENSENIASSLDEVRNMRILTTNLLNLARRDDGIKPELAVIKPTLFDSIFENYDLIAQENGKNFTGHNMIQD
SFKTDKTLLKQLMTILFDNAIKYTDNDGSIDFTISETDKYLFLEIADNGPGISEEDKVRIFDRFYRVDKARTRQQGGFGL
GLSLAQQIVNSLRGNITVIDNKPRGSIFKIKLPKVKG

Nucleotide


Download         Length: 1314 bp        

>NTDB_id=326094 EGX82_RS00370 WP_000042576.1 73419..74732(+) (ciaH) [Streptococcus agalactiae strain FDAARGOS_512]
ATGTCGAAACCGATTAAGATAAGTAAATTCAAAAAAAATGTCTCAGATAGTCATTTTATCCATTTTTTCACAGTTTTTAG
TGGTATTTTTCTGGTTATGACTGTTATCATCCTCCAAGTCATGCGCTATGGTGTTTATTCTTCTGTTGATAGTAGTTTAA
AGTATATCAGTACCCATCCTAAAAATTACATCAATATGGTTATGTCACGTACTGCTGCCTACCTAGATAACTCCAATATC
GCAAGTGTCAAGTTAAAACCCGGCGGTCAGACAGTAGCTAATACTGATATTATTCTTTTTACATCAGAAGAAGAAGTCAT
TAACTATTTTGACGCATTTTCAAACTATCAGTTTTTAAAACCTAATAAAAAAAATCTAGGTGGCATTAGTGAATTAACTT
TAACCAACATCTTTGGTCAAGATGAGACATATCATGCTGTCACCGTAAAAGTTAATAACCCTGCTTATCCTAATGTGACT
TACATGACAGCTATTGTTAATATTGATCAATTAGTAAATGCTAAAGAACGCTATGAAAAAATTATTATATTTGTCATGAC
TACTTTTTGGATTATTTCAATTGGAGCAAGTATCTACTTAGCTAAATGGGCACAAAAACCGATTATAGAAAACTACGAAA
GACAGAAGGCTTTTGTCGAAAATGCTAGCCACGAGCTGCGTACTCCCCTAGCTGTCTTACAAAATCGCCTAGAAACGCTA
TTCAGAAAACCGAATGCCACCATTTTAGAAAATAGTGAAAATATCGCTTCAAGTCTAGATGAAGTACGAAATATGCGTAT
TTTAACCACTAATCTTTTAAACTTAGCAAGACGTGATGATGGAATCAAACCAGAATTAGCTGTTATTAAGCCTACACTTT
TTGATAGTATCTTTGAGAATTATGATCTAATCGCCCAAGAGAATGGTAAAAATTTTACTGGACATAATATGATCCAAGAT
AGTTTCAAAACAGATAAGACACTGCTAAAACAACTCATGACTATTTTATTTGATAATGCTATAAAATATACTGACAATGA
TGGTAGCATTGACTTTACCATATCTGAAACTGATAAGTATCTCTTTTTAGAAATCGCTGATAATGGACCAGGAATTTCAG
AGGAGGATAAAGTCAGAATTTTTGATCGTTTTTACCGTGTTGACAAAGCAAGAACACGACAACAAGGAGGGTTTGGCCTC
GGCCTTTCTTTAGCTCAACAAATCGTTAACTCACTGCGAGGTAATATTACAGTAATTGATAATAAACCTAGAGGCAGTAT
TTTTAAGATAAAACTACCAAAAGTAAAAGGTTAG

Domains

Predicted by InterproScan.

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c)

(325-434)

His Kinase A (phospho-acceptor) domain (HisKA)

(216-281)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaH Streptococcus mutans UA159

60.373

98.169

0.593
  ciaH Streptococcus pneumoniae Rx1

52.143

96.11

0.501
  ciaH Streptococcus pneumoniae D39

52.143

96.11

0.501
  ciaH Streptococcus pneumoniae R6

52.143

96.11

0.501
  ciaH Streptococcus pneumoniae TIGR4

52.143

96.11

0.501

Multiple sequence alignment