Detailed information    

insolico Bioinformatically predicted

Overview

Name   vraR   Type   Regulator
Locus tag   FNL90_RS07315 Genome accession   NZ_CP041408
Coordinates   1412428..1413069 (-) Length   213 a.a.
NCBI ID   WP_002983671.1    Uniprot ID   A0A0H2UW05
Organism   Streptococcus pyogenes strain 37-97S     
Function   repress expression of competence genes (predicted from homology)   
Competence regulation

Genomic Context

Location: 1407428..1418069
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  FNL90_RS07290 (FNL90_07540) comFA/cflA 1407515..1408840 (-) 1326 WP_047235421.1 DEAD/DEAH box helicase Machinery gene
  FNL90_RS07295 (FNL90_07545) - 1408895..1409527 (+) 633 WP_002983676.1 YigZ family protein -
  FNL90_RS07300 (FNL90_07550) cysK 1409655..1410596 (+) 942 WP_011528853.1 cysteine synthase A -
  FNL90_RS07305 (FNL90_07555) - 1410614..1410991 (-) 378 WP_047235422.1 S1 RNA-binding domain-containing protein -
  FNL90_RS07310 (FNL90_07560) - 1410991..1412391 (-) 1401 WP_011054832.1 bifunctional Cof-type HAD-IIB family hydrolase/peptidylprolyl isomerase -
  FNL90_RS07315 (FNL90_07565) vraR 1412428..1413069 (-) 642 WP_002983671.1 response regulator transcription factor Regulator
  FNL90_RS07320 (FNL90_07570) - 1413062..1414066 (-) 1005 WP_002991890.1 sensor histidine kinase -
  FNL90_RS07325 (FNL90_07575) liaF 1414063..1414755 (-) 693 WP_011054833.1 cell wall-active antibiotics response protein LiaF -
  FNL90_RS07330 (FNL90_07580) pknB 1414878..1416776 (-) 1899 WP_012560855.1 Stk1 family PASTA domain-containing Ser/Thr kinase Regulator
  FNL90_RS07335 (FNL90_07585) - 1416773..1417513 (-) 741 WP_002983660.1 Stp1/IreP family PP2C-type Ser/Thr phosphatase -

Sequence

Protein


Download         Length: 213 a.a.        Molecular weight: 23751.43 Da        Isoelectric Point: 5.1641

>NTDB_id=325893 FNL90_RS07315 WP_002983671.1 1412428..1413069(-) (vraR) [Streptococcus pyogenes strain 37-97S]
MSKIKVILVDDHEMVRMGLKSFLNLQADIDVVGEASNGREGVDLALALKPDVLVMDLVMPELGGVEATLEVLKKWKEAKV
LVLTSYLDNEKIYPVIDAGAKGYMLKTSSAAEILNAIRKVSKGELAIETEVDKKIKAHDQHPDLHEELTAREYDILHLLA
KGYDNQTIADELFISLKTVKTHVSNILAKLEVDDRTQAVVYAFRHHLVPQDDN

Nucleotide


Download         Length: 642 bp        

>NTDB_id=325893 FNL90_RS07315 WP_002983671.1 1412428..1413069(-) (vraR) [Streptococcus pyogenes strain 37-97S]
ATGAGTAAGATAAAAGTGATATTGGTCGATGATCATGAAATGGTCCGCATGGGACTCAAGAGTTTTTTGAATTTACAAGC
TGATATTGATGTCGTTGGTGAGGCCTCTAATGGACGTGAAGGGGTTGATTTGGCATTGGCTTTGAAGCCAGATGTTTTGG
TTATGGATCTAGTGATGCCAGAGTTAGGCGGTGTTGAGGCAACTTTAGAAGTCCTAAAAAAATGGAAAGAGGCTAAGGTA
CTTGTGTTAACTTCCTATCTAGATAATGAAAAGATATACCCTGTCATTGATGCTGGTGCTAAAGGTTACATGTTAAAGAC
TTCTAGTGCAGCCGAAATTCTAAATGCTATTCGGAAAGTTTCAAAAGGTGAATTGGCCATTGAAACAGAGGTGGACAAAA
AAATTAAAGCGCATGACCAACACCCTGATTTGCATGAAGAGCTAACCGCGCGCGAGTATGATATTTTACATCTTTTAGCT
AAAGGGTATGATAATCAAACTATAGCGGATGAACTTTTCATCTCCTTGAAAACCGTTAAAACGCATGTATCTAATATTCT
TGCTAAGCTAGAAGTTGATGACCGAACTCAAGCGGTTGTCTATGCTTTTCGACACCATTTAGTCCCCCAAGACGATAATT
AA

Domains

Predicted by InterProScan.

Response regulator receiver domain (Response_reg)

(6-118)

Bacterial regulatory proteins, luxR family (GerE)

(148-202)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A0H2UW05

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  vraR Staphylococcus aureus N315

52.913

96.714

0.512
  degU Bacillus subtilis subsp. subtilis str. 168

36.283

100

0.385

Multiple sequence alignment