Detailed information NTG0325430

Bioinformatically predicted

Overview

• Name: crp
• Type: Regulator
• Locus tag: FLK62_RS02070
• Genome accession: NZ_CP041334
• Coordinates: 415788..416462 (-)
• Length: 224 a.a.
• NCBI ID: WP_010787261.1
• Uniprot ID: B8F851
• Organism: Glaesserella parasuis strain HPS412
• Function: promote expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 410788..421462

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
FLK62_RS02040 (FLK62_02050)	lolB	411266..411898 (+)	633	WP_160416011.1	lipoprotein insertase outer membrane protein LolB	-
FLK62_RS02045 (FLK62_02055)	ispE	411900..412745 (+)	846	WP_160416012.1	4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase	-
FLK62_RS02050 (FLK62_02060)	-	412773..413723 (+)	951	WP_005713153.1	ribose-phosphate pyrophosphokinase	-
FLK62_RS02055 (FLK62_02065)	pyrD	413969..414976 (+)	1008	WP_005713157.1	quinone-dependent dihydroorotate dehydrogenase	-
FLK62_RS02060 (FLK62_02070)	-	415097..415348 (-)	252	WP_041603192.1	hypothetical protein	-
FLK62_RS02065 (FLK62_02075)	-	415345..415536 (-)	192	WP_016528412.1	hypothetical protein	-
FLK62_RS02070 (FLK62_02080)	crp	415788..416462 (-)	675	WP_010787261.1	cAMP-activated global transcriptional regulator CRP	Regulator
FLK62_RS02075 (FLK62_02085)	-	416529..416753 (-)	225	WP_005713165.1	YheU family protein	-
FLK62_RS02080 (FLK62_02090)	slmA	416761..417366 (-)	606	WP_005713169.1	nucleoid occlusion factor SlmA	-
FLK62_RS02085 (FLK62_02095)	dut	417375..417830 (-)	456	WP_005713171.1	dUTP diphosphatase	-
FLK62_RS02090 (FLK62_02100)	-	417856..418182 (-)	327	WP_005713172.1	hypothetical protein	-
FLK62_RS02095 (FLK62_02105)	coaBC	418192..419394 (-)	1203	WP_176443425.1	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase CoaBC	-
FLK62_RS02100 (FLK62_02110)	radC	419563..420279 (+)	717	WP_005713175.1	DNA repair protein RadC	Machinery gene
FLK62_RS02105 (FLK62_02115)	rpmB	420405..420641 (+)	237	WP_005713177.1	50S ribosomal protein L28	-
FLK62_RS02110 (FLK62_02120)	rpmG	420653..420823 (+)	171	WP_005624479.1	50S ribosomal protein L33	-

Sequence

Protein

• Length: 224 a.a.
• Molecular weight: 25208.17 Da
• Isoelectric Point: 6.9079

>NTDB_id=325430 FLK62_RS02070 WP_010787261.1 415788..416462(-) (crp) [Glaesserella parasuis strain HPS412]
MQDVSISTAQLEDVSPLPSIHDPSVEWFLTHCHIHRYPAKYTLIHAGEDAESLFYIVSGAVSVFIKDEEGKEMLLTNLGQ
GEFVGEISLFEEKAQPRTAWVRTKGNCEIAEISYKKFKQLVHLNPDILMYLSAQMARRLRMTSRQVSNLAFLDVTGRIAQ
TLMNLAKMPDAMTHPQGMQIKITRQEIGQMVGCSRETVGRILKMLEDEGLISAHGKTIVVYGTR

Nucleotide

• Length: 675 bp

>NTDB_id=325430 FLK62_RS02070 WP_010787261.1 415788..416462(-) (crp) [Glaesserella parasuis strain HPS412]
ATGCAAGATGTTTCAATCTCAACCGCACAGCTTGAAGATGTCAGCCCATTACCATCCATTCACGATCCTTCGGTGGAATG
GTTTTTAACTCACTGTCATATTCATCGTTATCCAGCAAAATATACTTTAATTCACGCAGGTGAAGATGCTGAATCACTGT
TTTATATTGTCAGCGGAGCTGTGTCTGTCTTTATCAAGGATGAAGAAGGCAAGGAGATGTTATTAACCAATTTAGGACAA
GGCGAATTTGTCGGTGAAATCAGCCTTTTTGAAGAAAAGGCTCAGCCTCGCACTGCTTGGGTAAGAACTAAAGGCAACTG
TGAAATTGCTGAAATTTCTTATAAAAAATTCAAGCAATTAGTGCATCTTAATCCAGATATTTTGATGTATTTATCCGCAC
AGATGGCTCGCCGTTTACGAATGACATCAAGGCAGGTTAGCAACCTAGCATTCCTTGATGTAACAGGTCGTATTGCTCAA
ACATTGATGAATTTAGCTAAAATGCCTGATGCGATGACTCACCCTCAGGGTATGCAAATTAAAATTACTCGTCAAGAAAT
TGGGCAAATGGTCGGTTGCTCACGAGAAACTGTTGGTCGTATTTTGAAAATGCTTGAGGATGAAGGGTTAATCTCTGCAC
ATGGTAAAACTATCGTGGTGTATGGGACAAGATAA

Domains

Predicted by InterProScan.

• Cyclic nucleotide-binding domain (cNMP_binding) (35-121)

• Crp-like helix-turn-helix domain (HTH_Crp_2) (156-220)

3D structure

• AlphaFold DB: B8F851

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
crp	Vibrio cholerae strain A1552	75.862	90.625	0.687
crp	Haemophilus influenzae Rd KW20	73.399	90.625	0.665
crp	Acinetobacter baumannii D1279779	48.5	89.286	0.433