Detailed information NTG0323015

Bioinformatically predicted

Overview

• Name: vicK
• Type: Regulator
• Locus tag: EB818_RS02345
• Genome accession: NZ_CP033335
• Coordinates: 431781..433133 (+)
• Length: 450 a.a.
• NCBI ID: WP_129322616.1
• Uniprot ID: -
• Organism: Streptococcus pyogenes strain TSPY208
• Function: repress comCDE expression; repress comX expression (predicted from homology) Competence regulation

Genomic Context

Location: 426781..438133

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
EB818_RS02320 (EB818_02330)	-	426930..427079 (+)	150	WP_002994198.1	hypothetical protein	-
EB818_RS02325 (EB818_02335)	-	427474..428622 (+)	1149	WP_129322614.1	acetyl-CoA C-acyltransferase	-
EB818_RS02330 (EB818_02340)	-	428579..429826 (+)	1248	WP_129322615.1	AMP-binding protein	-
EB818_RS02335 (EB818_02345)	-	429882..430916 (+)	1035	WP_011284595.1	DUF3114 domain-containing protein	-
EB818_RS02340 (EB818_02350)	vicR	431078..431788 (+)	711	WP_002985645.1	response regulator YycF	Regulator
EB818_RS02345 (EB818_02355)	vicK	431781..433133 (+)	1353	WP_129322616.1	cell wall metabolism sensor histidine kinase VicK	Regulator
EB818_RS02350 (EB818_02360)	vicX	433137..433946 (+)	810	WP_129322617.1	MBL fold metallo-hydrolase	Regulator
EB818_RS02355 (EB818_02365)	rnc	434400..435092 (+)	693	WP_002985639.1	ribonuclease III	-

Sequence

Protein

• Length: 450 a.a.
• Molecular weight: 51466.97 Da
• Isoelectric Point: 5.7395

>NTDB_id=323015 EB818_RS02345 WP_129322616.1 431781..433133(+) (vicK) [Streptococcus pyogenes strain TSPY208]
MTRDIIGNLSTFELAILILLVFVAFYFIHLAVRDYRNARIIRMMSHKIRYLINGRYTDIIDEKADIELMELSDQLNDLSD
VFRLTHENLAQEKNRLASILAYMSDGVLATDRSGKIIMINETARKQLNLSKEEALKKNITDLLEGDTSYTYRDLVSKTPV
VTVNSRNDMGEFVSLRLRFALNRRESGFISGLVVVLHDTTEQEKEERERRLFVSNVSHELRTPLTSVKSYLEALDEGALK
EDIAPSFIKVSLDETNRMMRMISDLLNLSRIDNQVTQLAVEMTNFTAFITSILNRFDLVKNQHTGTGKVYEIVRDYPITS
VWIEIDNDKMTQVIENILNNAIKYSPDGGKITVRMKTTDTQLIISISDQGLGIPKKDLPLIFDRFYRVDKARSRAQGGTG
LGLAIAKEIIKQHHGFIWAKSDYGKGSTFTIVLPYEKDAAIYEEWEDDID

Nucleotide

• Length: 1353 bp

>NTDB_id=323015 EB818_RS02345 WP_129322616.1 431781..433133(+) (vicK) [Streptococcus pyogenes strain TSPY208]
ATGACTAGAGATATCATTGGAAACTTATCCACATTTGAATTAGCGATCCTTATCTTACTTGTTTTTGTTGCTTTTTACTT
TATCCATCTTGCGGTGCGTGATTACCGAAATGCACGTATTATTCGGATGATGAGCCATAAAATCCGATACTTGATTAATG
GTCGCTATACTGATATAATCGACGAAAAAGCAGACATTGAGTTAATGGAGCTTTCAGACCAGTTAAATGACCTGTCAGAT
GTTTTTCGCTTGACGCATGAAAATCTTGCCCAAGAAAAAAATCGCTTGGCAAGTATTTTGGCTTATATGTCAGATGGTGT
ACTTGCTACAGACCGGTCTGGTAAAATCATCATGATTAACGAAACAGCTCGCAAGCAATTAAATTTAAGTAAAGAAGAGG
CACTAAAGAAAAACATTACAGATTTGTTAGAAGGTGATACTTCATATACCTACCGTGATTTGGTATCCAAAACACCAGTG
GTAACTGTTAATAGCCGAAATGATATGGGTGAGTTTGTCTCATTACGCTTGCGCTTTGCGTTGAATAGGAGAGAGAGTGG
TTTTATTTCGGGCTTGGTTGTGGTGCTCCATGACACCACAGAACAAGAAAAAGAAGAACGTGAACGCCGTCTTTTTGTCT
CTAATGTAAGTCATGAATTAAGGACCCCTTTAACTTCGGTTAAATCCTACTTGGAGGCTCTTGATGAAGGTGCACTTAAA
GAAGATATTGCTCCAAGTTTCATAAAAGTTTCTCTTGATGAAACTAATCGGATGATGCGTATGATTTCAGATCTTTTAAA
CCTGTCTCGGATTGATAATCAAGTAACCCAATTAGCAGTAGAGATGACTAATTTTACTGCTTTTATAACTTCTATTTTAA
ACAGATTTGATTTGGTTAAAAATCAGCATACAGGTACAGGAAAAGTCTATGAAATTGTAAGAGATTACCCTATTACCTCT
GTCTGGATTGAAATTGATAATGATAAAATGACGCAGGTTATTGAAAATATCCTAAACAACGCGATTAAATACTCTCCTGA
TGGTGGGAAAATCACTGTTCGCATGAAAACAACCGACACGCAATTGATTATTTCCATCTCAGACCAAGGCTTAGGCATTC
CGAAGAAGGACCTGCCCCTTATTTTTGACCGTTTTTACCGAGTGGACAAGGCAAGAAGCCGTGCTCAAGGTGGAACTGGT
CTAGGGCTTGCCATTGCCAAAGAAATTATTAAGCAGCATCACGGGTTTATCTGGGCGAAGAGTGATTATGGCAAAGGGTC
AACCTTTACCATCGTCTTGCCATATGAAAAAGATGCTGCCATTTACGAAGAGTGGGAGGATGACATAGATTAA

Domains

Predicted by InterproScan.

• His Kinase A (phospho-acceptor) domain (HisKA) (209-273)

• PAS fold (PAS) (95-162)

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (326-436)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vicK	Streptococcus mutans UA159	73.188	92	0.673
micB	Streptococcus pneumoniae Cp1015	67.529	94.444	0.638