Detailed information    

insolico Bioinformatically predicted

Overview

Name   vicK   Type   Regulator
Locus tag   MGAS28085_RS07030 Genome accession   NZ_CP032666
Coordinates   1400155..1401507 (-) Length   450 a.a.
NCBI ID   WP_002995609.1    Uniprot ID   A0A4U7GC27
Organism   Streptococcus pyogenes strain MGAS28085     
Function   repress comCDE expression; repress comX expression (predicted from homology)   
Competence regulation

Genomic Context

Location: 1395155..1406507
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  MGAS28085_RS07020 (MGAS28085_07020) rnc 1398217..1398909 (-) 693 WP_011284596.1 ribonuclease III -
  MGAS28085_RS07025 (MGAS28085_07025) vicX 1399342..1400151 (-) 810 WP_002985641.1 MBL fold metallo-hydrolase Regulator
  MGAS28085_RS07030 (MGAS28085_07030) vicK 1400155..1401507 (-) 1353 WP_002995609.1 cell wall metabolism sensor histidine kinase VicK Regulator
  MGAS28085_RS07035 (MGAS28085_07035) vicR 1401500..1402210 (-) 711 WP_002985645.1 response regulator YycF Regulator
  MGAS28085_RS07040 (MGAS28085_07040) - 1402372..1403406 (-) 1035 WP_011284595.1 DUF3114 domain-containing protein -
  MGAS28085_RS07045 (MGAS28085_07045) - 1403462..1404709 (-) 1248 WP_011284594.1 AMP-binding protein -
  MGAS28085_RS07050 (MGAS28085_07050) - 1404666..1405814 (-) 1149 WP_011284593.1 acetyl-CoA C-acyltransferase -
  MGAS28085_RS07055 (MGAS28085_07055) - 1406209..1406358 (-) 150 WP_002990686.1 hypothetical protein -

Sequence

Protein


Download         Length: 450 a.a.        Molecular weight: 51391.82 Da        Isoelectric Point: 5.4026

>NTDB_id=317819 MGAS28085_RS07030 WP_002995609.1 1400155..1401507(-) (vicK) [Streptococcus pyogenes strain MGAS28085]
MTRDIIGNLSTFELAILILLVFVAFYFIHLAVRDYRNARIIRMMSHKIRDLINGRYTDIIDEKADIELMELSDQLNDLSD
VFRLTHENLAQEKNRLASILAYMSDGVLATDRSGKIIMINETARKQLNLSKEEALKKNITDLLEGDTSYTYRDLVSKTPV
VTVNSRNDMGEFVSLRLRFALNRRESGFISGLVVVLHDTTEQEKEERERRLFVSNVSHELRTPLTSVKSYLEALDEGALK
EDIAPSFIKVSLDETNRMMRMISDLLNLSRIDNQVTQLAVEMTNFTAFITSILNRFDLVKNQHTGTGKVYEIVRDYPITS
VWIEIDNDKMTQVIENILNNAIKYSPDGGKITVRMKTTDTQLIISISDQGLGIPKTDLPLIFDRFYRVDKARSRAQGGTG
LGLAIAKEIIKQHHGFIWAKSDYGKGSTFTIVLPYEKDAAIYEEWEEDVD

Nucleotide


Download         Length: 1353 bp        

>NTDB_id=317819 MGAS28085_RS07030 WP_002995609.1 1400155..1401507(-) (vicK) [Streptococcus pyogenes strain MGAS28085]
ATGACTAGAGATATCATTGGAAACTTATCCACATTTGAATTAGCGATCCTTATCTTACTTGTTTTTGTTGCTTTTTACTT
TATCCATCTTGCGGTGCGTGATTACCGAAATGCACGTATTATTCGGATGATGAGCCATAAAATCCGAGACTTGATTAATG
GTCGCTATACTGATATAATCGACGAAAAAGCAGACATTGAGTTAATGGAGCTTTCAGACCAGTTAAATGACCTATCAGAT
GTTTTTCGCTTGACGCATGAAAATCTTGCCCAAGAAAAAAATCGCTTGGCAAGTATTTTGGCTTATATGTCAGATGGTGT
ACTTGCTACAGACCGGTCTGGTAAAATCATCATGATTAACGAGACAGCTCGCAAGCAATTAAATTTAAGTAAAGAAGAGG
CACTAAAGAAAAACATTACAGATTTGTTAGAAGGTGATACTTCATATACCTACCGTGATTTGGTATCTAAAACACCAGTG
GTAACTGTTAATAGCCGAAATGATATGGGTGAGTTTGTCTCATTACGCTTGCGCTTTGCGTTGAATAGGAGAGAGAGTGG
TTTTATTTCGGGCTTGGTTGTGGTGCTCCATGACACCACAGAACAAGAAAAAGAAGAACGTGAACGCCGTCTTTTTGTCT
CTAATGTAAGTCATGAATTAAGGACCCCTTTAACTTCGGTTAAATCCTACTTGGAGGCTCTTGATGAAGGTGCACTTAAA
GAAGATATTGCTCCAAGTTTCATAAAAGTTTCTCTTGATGAAACTAATCGGATGATGCGTATGATTTCAGATCTTTTAAA
CCTGTCTCGGATTGATAATCAAGTAACCCAATTAGCAGTAGAGATGACTAATTTTACTGCTTTTATAACTTCTATTTTAA
ACAGATTTGATTTGGTTAAAAATCAGCATACAGGTACAGGAAAAGTCTATGAAATTGTAAGAGATTACCCTATTACCTCT
GTCTGGATTGAAATTGATAATGATAAAATGACACAGGTTATCGAGAATATTTTGAACAATGCCATTAAGTATTCTCCAGA
TGGTGGAAAAATCACAGTCCGTATGAAAACAACAGATACCCAATTAATTATTTCCATTTCAGACCAAGGACTAGGTATCC
CTAAAACAGATTTGCCTCTTATTTTTGATCGGTTCTATCGTGTAGACAAGGCAAGAAGTCGTGCCCAAGGAGGGACCGGT
CTAGGCCTTGCCATTGCTAAAGAAATCATCAAGCAGCACCATGGCTTTATCTGGGCTAAGAGTGACTATGGTAAAGGATC
GACCTTTACTATTGTCTTGCCTTATGAAAAAGATGCAGCCATCTATGAAGAATGGGAGGAAGATGTAGACTAA

Domains

Predicted by InterproScan.

PAS fold (PAS)

(95-162)

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c)

(326-436)

His Kinase A (phospho-acceptor) domain (HisKA)

(209-273)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A4U7GC27

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  vicK Streptococcus mutans UA159

72.947

92

0.671
  micB Streptococcus pneumoniae Cp1015

67.765

94.444

0.64

Multiple sequence alignment