Detailed information    

insolico Bioinformatically predicted

Overview

Name   comE/blpR   Type   Regulator
Locus tag   SEZ_RS07370 Genome accession   NC_011134
Coordinates   1569036..1569785 (-) Length   249 a.a.
NCBI ID   WP_012516119.1    Uniprot ID   B4U4E3
Organism   Streptococcus equi subsp. zooepidemicus MGCS10565     
Function   activate transcription of early competence genes; regulation of comX expression (predicted from homology)   
Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
IScluster/Tn 1570082..1576732 1569036..1569785 flank 297


Gene organization within MGE regions


Location: 1569036..1576732
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  SEZ_RS07370 (Sez_1527) comE/blpR 1569036..1569785 (-) 750 WP_012516119.1 response regulator transcription factor Regulator
  SEZ_RS07375 (Sez_1528) - 1570082..1571035 (-) 954 WP_012514856.1 IS30 family transposase -
  SEZ_RS07380 (Sez_1529) - 1571510..1571713 (-) 204 WP_012516120.1 TmhB bacteriocin enhancer peptide -
  SEZ_RS07385 (Sez_1530) - 1571730..1571987 (-) 258 WP_012516121.1 Blp family class II bacteriocin -
  SEZ_RS07390 (Sez_1531) rlmD 1572308..1573675 (-) 1368 WP_012516122.1 23S rRNA (uracil(1939)-C(5))-methyltransferase RlmD -
  SEZ_RS07395 (Sez_1532) - 1573672..1574640 (-) 969 WP_012516123.1 helix-hairpin-helix domain-containing protein -
  SEZ_RS09730 - 1574761..1574919 (-) 159 WP_228275460.1 DUF4368 domain-containing protein -
  SEZ_RS07405 (Sez_1534) - 1575390..1576732 (+) 1343 WP_165626751.1 IS3 family transposase -

Sequence

Protein


Download         Length: 249 a.a.        Molecular weight: 29208.64 Da        Isoelectric Point: 8.4569

>NTDB_id=31385 SEZ_RS07370 WP_012516119.1 1569036..1569785(-) (comE/blpR) [Streptococcus equi subsp. zooepidemicus MGCS10565]
MRVVILEDDMIQQRYLEKLIKELEVKHQLLFQGLDCFGRSHQLLSAIKKNCGQQLFFLDIEIKNEDKKGLEVARQIRQIN
PDAMIVFVTTHSEFMPLAFQYQVSALDYIDKELPQTEFVQRVETALLYAVRQNSETIAESAFYFTSRYAQVQVPFNDILY
IETSSRAHRVNLYTKKERMQFTGTLTDILKQESRFLQCHRSFLINPRNVVRVDKIERVVYFRNGSSCLIARSKMNSVLTT
IENLHRGDN

Nucleotide


Download         Length: 750 bp        

>NTDB_id=31385 SEZ_RS07370 WP_012516119.1 1569036..1569785(-) (comE/blpR) [Streptococcus equi subsp. zooepidemicus MGCS10565]
GTGAGAGTAGTTATTTTAGAAGATGATATGATTCAGCAGAGATATTTAGAAAAGCTCATTAAAGAGCTTGAGGTTAAGCA
CCAGCTATTATTTCAAGGACTTGACTGTTTTGGAAGGTCTCACCAGCTATTAAGTGCTATCAAGAAGAACTGTGGTCAGC
AGCTATTCTTTTTAGATATTGAGATAAAAAATGAGGACAAAAAAGGGCTTGAGGTTGCTAGGCAAATTCGTCAGATAAAT
CCAGATGCGATGATTGTTTTTGTAACGACTCACTCGGAATTTATGCCCTTGGCTTTTCAGTATCAGGTATCTGCTTTGGA
CTATATCGATAAAGAGCTGCCCCAAACTGAGTTTGTTCAACGGGTAGAGACTGCTTTATTATATGCTGTGCGGCAAAATA
GTGAAACGATAGCGGAAAGTGCTTTTTATTTTACATCTCGTTATGCTCAGGTACAGGTGCCTTTTAATGATATCCTGTAT
ATTGAGACATCGTCACGAGCGCATCGTGTCAATTTGTATACAAAAAAGGAGAGAATGCAATTTACAGGGACTTTGACGGA
TATTTTGAAGCAAGAGTCTCGTTTTTTGCAATGTCATCGTTCTTTTTTGATTAATCCTAGGAATGTCGTTAGGGTAGATA
AGATTGAGCGAGTGGTTTATTTTCGAAATGGCTCTAGCTGCTTAATTGCTCGTAGTAAAATGAACAGTGTTTTAACAACA
ATTGAGAACCTACATAGAGGAGATAATTAA

Domains

Predicted by InterproScan.

LytTr DNA-binding domain (LytTR)

(151-237)

Response regulator receiver domain (Response_reg)

(3-122)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB B4U4E3

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comE/blpR Streptococcus mutans UA159

52.209

100

0.522
  comE/comE1 Streptococcus equinus JB1

40.586

95.984

0.39
  comE/comE2 Streptococcus equinus JB1

36.29

99.598

0.361

Multiple sequence alignment