Detailed information NTG0310331

Bioinformatically predicted

Overview

• Name: ciaH
• Type: Regulator
• Locus tag: ES298_RS03720
• Genome accession: NZ_CP038253
• Coordinates: 735223..736557 (+)
• Length: 444 a.a.
• NCBI ID: WP_000491795.1
• Uniprot ID: -
• Organism: Streptococcus pneumoniae strain TVO_1901929
• Function: repress competence development; post-transcriptional repression of CSP production (predicted from homology) Competence regulation

Genomic Context

Location: 730223..741557

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ES298_RS03705 (ES298_03895)	-	730482..733028 (+)	2547	WP_001149111.1	M1 family metallopeptidase	-
ES298_RS03710 (ES298_03900)	-	733107..734363 (-)	1257	WP_000530081.1	ISL3 family transposase	-
ES298_RS03715 (ES298_03905)	ciaR	734559..735233 (+)	675	WP_000590640.1	two-component system response regulator CiaR	Regulator
ES298_RS03720 (ES298_03910)	ciaH	735223..736557 (+)	1335	WP_000491795.1	two-component system sensor histidine kinase CiaH	Regulator
ES298_RS03725 (ES298_03915)	-	736591..736878 (-)	288	WP_001145225.1	DUF3270 domain-containing protein	-
ES298_RS03730 (ES298_03920)	-	737018..737947 (+)	930	WP_000411847.1	peptidase U32 family protein	-
ES298_RS03735 (ES298_03930)	-	738147..740597 (+)	2451	WP_000848697.1	bifunctional DnaQ family exonuclease/ATP-dependent helicase	-

Sequence

Protein

• Length: 444 a.a.
• Molecular weight: 50672.40 Da
• Isoelectric Point: 9.3547

>NTDB_id=310331 ES298_RS03720 WP_000491795.1 735223..736557(+) (ciaH) [Streptococcus pneumoniae strain TVO_1901929]
MFSKLKKTWYADDFSYFIRNFGVFTLIFSTMTLIILQVMHSSLYTSVDDKLHGLSENPQAVIQLAINRATEEIKDLENAR
ADASKVEIKPNVSSNTEVILFDKDFTQLLSGNRFLGLDKIKLEKKELGHIYQIQVFNSYGQEEIYRVILMETNISSVSTN
IKYAAVLINTSQLEQASQKHEQLIVVVMASFWILSLLASLYLARVSVRPLLESMQKQQSFVENASHELRTPLAVLQNRLE
TLFRKPEATIMDVSESIASSLEEVRNMRFLTTSLLNLARRDDGIKPELAEVPTSFFNTTFTNYEMIASENNRVFRFENRI
HRTIVTDQLLLKQLMTILFDNAVKYTEEDGEINFLISATDRNLYLLVSDNGIGISTEDKKKIFDRFYRVDKARTRQKGGF
GLGLSLAKQIVDALKGTVTVKDNKPKGTIFEVKIAIQTPSKKKK

Nucleotide

• Length: 1335 bp

>NTDB_id=310331 ES298_RS03720 WP_000491795.1 735223..736557(+) (ciaH) [Streptococcus pneumoniae strain TVO_1901929]
ATGTTCAGTAAACTTAAAAAAACATGGTATGCGGATGACTTTAGTTATTTTATCCGCAACTTCGGTGTCTTCACCCTGAT
TTTTTCTACAATGACTCTGATTATTTTACAAGTCATGCATTCGAGTCTTTATACTTCGGTGGACGATAAGCTTCATGGAC
TGAGTGAAAATCCTCAAGCAGTTATTCAGCTGGCTATAAATAGGGCAACAGAAGAGATTAAAGATTTAGAAAATGCTAGG
GCGGACGCTAGTAAAGTAGAAATAAAACCTAATGTCAGTTCCAATACGGAAGTCATTCTCTTTGATAAAGACTTTACTCA
ACTTCTTTCTGGAAATCGATTTTTGGGCTTGGATAAGATTAAGTTAGAAAAGAAAGAACTAGGACATATCTACCAGATTC
AGGTTTTTAATAGCTATGGGCAGGAAGAAATCTATCGTGTGATTTTGATGGAGACCAATATTAGTTCGGTTTCAACCAAT
ATCAAGTATGCTGCTGTCTTGATTAATACCAGTCAGTTGGAGCAGGCTAGTCAAAAGCATGAGCAATTGATTGTGGTCGT
GATGGCTAGTTTCTGGATTTTGTCTTTACTTGCCAGTCTCTATCTAGCTAGGGTCAGTGTTAGGCCCCTGCTTGAGAGTA
TGCAGAAGCAACAGTCTTTTGTGGAAAATGCCAGTCATGAGTTACGAACTCCACTCGCAGTTTTGCAAAATCGCTTAGAG
ACCCTTTTTCGTAAGCCAGAAGCTACCATTATGGATGTGAGCGAAAGCATTGCATCGAGTTTGGAAGAAGTCCGAAATAT
GCGTTTTTTAACGACAAGCTTGCTGAACTTAGCTCGGAGAGATGATGGGATTAAGCCGGAGCTTGCAGAAGTTCCAACTA
GCTTTTTTAATACAACTTTCACAAACTACGAGATGATTGCTTCGGAAAATAATCGTGTCTTCCGTTTTGAAAATCGTATC
CATCGAACAATTGTCACAGATCAGCTTCTTCTGAAACAACTGATGACCATTCTTTTCGATAATGCCGTCAAGTATACTGA
GGAGGATGGTGAAATTAATTTTCTTATCTCGGCGACCGATCGCAATCTTTATTTACTTGTTTCTGATAATGGAATCGGTA
TTTCGACAGAAGATAAAAAGAAAATTTTTGACCGTTTTTATCGAGTAGACAAAGCTAGAACCCGGCAAAAAGGTGGTTTT
GGTTTAGGATTATCCCTAGCCAAGCAAATTGTAGATGCTCTAAAAGGAACTGTTACTGTCAAAGATAATAAACCCAAGGG
AACAATCTTTGAAGTGAAGATTGCCATTCAGACACCATCTAAAAAGAAAAAATAA

Domains

Predicted by InterProScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (327-434)

• His Kinase A (phospho-acceptor) domain (HisKA) (217-283)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
ciaH	Streptococcus pneumoniae Rx1	99.775	100	0.998
ciaH	Streptococcus pneumoniae D39	99.775	100	0.998
ciaH	Streptococcus pneumoniae R6	99.775	100	0.998
ciaH	Streptococcus pneumoniae TIGR4	99.775	100	0.998
ciaH	Streptococcus mutans UA159	55.632	97.973	0.545