Detailed information NTG0309200

Bioinformatically predicted

Overview

• Name: hexA
• Type: Machinery gene
• Locus tag: E3C75_RS02310
• Genome accession: NZ_CP038020
• Coordinates: 426466..429024 (+)
• Length: 852 a.a.
• NCBI ID: WP_111679079.1
• Uniprot ID: -
• Organism: Streptococcus thermophilus strain ATCC 19258
• Function: DNA mismatch repair (predicted from homology) Homologous recombination

Genomic Context

Location: 421466..434024

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
E3C75_RS02280	-	422999..423184 (+)	186	WP_111679073.1	hypothetical protein	-
E3C75_RS02285	-	423250..423477 (+)	228	WP_223899748.1	hypothetical protein	-
E3C75_RS02290	prx	423958..424146 (+)	189	WP_111679075.1	hypothetical protein	Regulator
E3C75_RS02295	-	424527..425216 (+)	690	WP_197709066.1	DUF3800 domain-containing protein	-
E3C75_RS02300	argR	425686..426114 (+)	429	WP_024704313.1	arginine repressor	-
E3C75_RS02305	-	426114..426473 (+)	360	WP_064355739.1	YlbF family regulator	-
E3C75_RS02310	hexA	426466..429024 (+)	2559	WP_111679079.1	DNA mismatch repair protein MutS	Machinery gene
E3C75_RS02315	-	429058..429513 (-)	456	WP_084825708.1	DUF3021 domain-containing protein	-
E3C75_RS02320	brsR	429510..429947 (-)	438	WP_111679081.1	LytTR family DNA-binding domain-containing protein	Regulator
E3C75_RS02325	-	430126..430431 (+)	306	WP_084830425.1	hypothetical protein	-
E3C75_RS02330	hexB	430483..432426 (+)	1944	WP_011680601.1	DNA mismatch repair endonuclease MutL	Machinery gene
E3C75_RS02335	-	432557..432778 (+)	222	WP_011680602.1	hypothetical protein	-
E3C75_RS02340	ruvA	432930..433520 (+)	591	WP_111679083.1	Holliday junction branch migration protein RuvA	Machinery gene

Sequence

Protein

• Length: 852 a.a.
• Molecular weight: 95456.78 Da
• Isoelectric Point: 4.6973

>NTDB_id=309200 E3C75_RS02310 WP_111679079.1 426466..429024(+) (hexA) [Streptococcus thermophilus strain ATCC 19258]
MAKEKISPGMQQYLDIKENYPDAFLLFRMGDFYELFYDDAIKAAQILEISLTSRNKNADNPIPMAGVPYHSAQAYIDVLV
EMGYKVAIAEQMEDPKQAVGVVKREVVQVITPGTVVDSSKPDSANNFLVAIDKVGSRFGLSYMDVSTGEFFATELDDFSS
VCSEIQNLKAREVVVGYDLLETDEQVLVNQLNLLLSKEIEGYDDVHLIGNSLTDLESSVAGKLLQYVHRTQMRELSHLQK
AQHYEIKDYLQMSYATKSSLDLLENARTGKKHGSLFWLLDETKTAMGMRLLRTWIDRPLVNQATIIERQNIIQVFLDNFF
ERSDLTESLKGVYDIERLASRVSFGKANPKDLIQLGHTLAQVPVIKAILESFNDDALSGLLQELDALPELESLIRLAIDP
DAPATITEGGIIRDGFDETLDKYRKVMSEGTSWIADIEAKEREASGITTLKIDYNRKDGYYFHVTNSNLSLVPDHFFRKA
TLKNSERFGTAELAKIEGEMLEAREKSSTLEYDIFMRVREQVERYIDRLQSLAKAIATVDVLQSLAVTAEKNHYVRPVFN
DEHRIAIDRGRHAVVEKVMGVQEYIPNTITFDSQTNIQLITGPNMSGKSTYMRQLALSVVMAQMGAYVPADSVDLPIFDA
IYTRIGAADDLISGQSTFMVEMLEANQAIKRATPNSLIIFDELGRGTATYDGMALAQSIIEFIHDKVGAKTMFATHYHEL
TALSNSLTHLVNVHVATLEKDGEVTFLHKIVDGPADKSYGIHVAKIAGLPIDLLNRADTILTQLEGETVVIQPQEKVSSQ
EKPAIETHVNEQISLFGDFTENPVLQELRDLDIYNMTPMQVMMAVADLKQKL

Nucleotide

• Length: 2559 bp

>NTDB_id=309200 E3C75_RS02310 WP_111679079.1 426466..429024(+) (hexA) [Streptococcus thermophilus strain ATCC 19258]
ATGGCTAAGGAAAAAATATCTCCAGGAATGCAGCAGTATTTGGATATCAAGGAAAATTATCCAGATGCTTTTTTGCTGTT
TCGGATGGGGGATTTTTACGAATTATTTTACGATGATGCTATTAAGGCTGCCCAGATTTTAGAAATTAGCCTAACTAGCC
GTAATAAGAATGCAGATAATCCCATTCCTATGGCAGGTGTGCCTTATCATTCAGCTCAAGCATACATTGATGTTTTGGTT
GAGATGGGCTACAAGGTAGCCATTGCTGAGCAGATGGAGGATCCTAAGCAGGCTGTCGGTGTGGTAAAGCGTGAGGTTGT
TCAGGTTATCACACCAGGTACAGTGGTTGACAGCTCTAAACCTGATAGTGCCAACAATTTCTTGGTGGCCATTGACAAGG
TTGGAAGTCGTTTTGGTCTTTCCTATATGGATGTGTCAACGGGTGAATTTTTTGCGACGGAGTTAGATGATTTTAGTTCA
GTTTGTAGTGAAATTCAGAACCTTAAGGCGCGTGAAGTAGTGGTTGGATATGATCTACTTGAAACTGACGAACAAGTTTT
AGTGAACCAACTTAACCTACTTCTCTCCAAGGAAATAGAAGGTTACGATGATGTTCACTTGATTGGTAATAGCTTGACAG
ATTTGGAAAGCAGTGTGGCGGGTAAACTTCTCCAGTATGTTCATCGCACTCAGATGCGTGAGCTCAGTCATTTACAAAAA
GCTCAGCACTATGAGATAAAGGATTACTTGCAGATGTCCTATGCGACCAAGTCAAGCTTGGATTTACTGGAAAATGCTAG
AACGGGCAAGAAACACGGTTCTCTTTTCTGGCTCTTGGATGAAACCAAGACAGCCATGGGAATGCGTCTCTTGCGAACTT
GGATTGATCGTCCTTTAGTGAATCAAGCCACCATCATAGAGCGTCAGAATATTATCCAAGTTTTCTTGGACAATTTCTTT
GAACGTAGTGACTTGACCGAGAGTCTAAAAGGTGTTTACGATATTGAGCGTCTGGCCAGTCGTGTTTCCTTTGGCAAGGC
TAATCCTAAAGATTTGATTCAGCTAGGTCATACCTTAGCTCAGGTTCCGGTCATTAAGGCAATCTTGGAGTCCTTTAATG
ACGATGCCTTGTCAGGTCTTTTACAAGAGTTAGATGCTTTGCCAGAATTAGAGAGTTTGATTCGTTTGGCTATTGATCCT
GATGCTCCAGCAACAATTACAGAAGGTGGTATTATCCGTGATGGTTTTGATGAGACCTTGGACAAGTATCGCAAAGTGAT
GAGCGAGGGGACGTCATGGATTGCGGATATCGAAGCCAAAGAACGTGAAGCGTCTGGTATTACAACACTAAAAATTGATT
ATAACCGTAAAGATGGTTATTATTTCCATGTGACCAACTCTAACCTTAGCTTGGTTCCTGACCATTTCTTCCGTAAGGCG
ACACTGAAAAATTCGGAGCGTTTTGGAACTGCTGAGTTGGCTAAGATTGAAGGTGAAATGCTAGAAGCGCGTGAAAAATC
GTCAACCCTAGAGTATGATATTTTCATGCGTGTCCGTGAGCAAGTTGAACGCTATATCGACCGTTTGCAGTCTTTGGCTA
AGGCCATTGCGACAGTCGATGTGCTTCAGAGTTTGGCTGTTACAGCGGAGAAAAATCATTATGTTCGTCCTGTTTTTAAT
GATGAGCATCGTATCGCTATTGATCGGGGCCGTCATGCGGTGGTTGAGAAGGTTATGGGCGTTCAGGAATACATTCCAAA
TACGATTACCTTTGACAGTCAGACCAATATTCAGCTCATCACAGGACCAAATATGAGTGGTAAATCTACCTATATGCGGC
AGTTAGCCTTGTCAGTAGTTATGGCTCAAATGGGGGCTTACGTACCAGCAGATAGTGTTGATTTACCAATTTTTGACGCC
ATCTATACACGTATAGGTGCCGCAGATGACCTGATTTCAGGTCAGTCGACCTTCATGGTTGAGATGCTGGAGGCTAATCA
GGCCATTAAGCGAGCGACACCTAATTCCTTGATTATTTTTGATGAGTTGGGGCGTGGGACAGCCACTTATGATGGTATGG
CTTTGGCCCAGTCTATTATTGAGTTTATTCATGACAAGGTGGGGGCTAAGACCATGTTTGCTACCCATTATCATGAGTTG
ACTGCGCTATCAAACAGTTTGACACACCTTGTCAACGTCCATGTTGCGACACTTGAAAAGGATGGCGAAGTGACTTTCCT
CCACAAAATTGTCGATGGTCCAGCTGATAAATCTTATGGTATTCATGTAGCTAAAATTGCAGGTTTACCAATAGATTTAT
TGAACCGTGCTGACACCATATTGACACAATTAGAAGGAGAGACAGTTGTAATCCAACCTCAGGAAAAGGTATCGTCTCAA
GAAAAGCCTGCCATTGAAACGCATGTCAACGAGCAAATCTCTCTCTTTGGTGACTTTACTGAAAATCCAGTTCTTCAAGA
GTTGCGTGATTTGGACATTTACAACATGACACCGATGCAAGTCATGATGGCTGTAGCAGATTTAAAACAGAAACTATAA

Domains

Predicted by InterProScan.

• MutS domain I (MutS_I) (8-118)

• MutS family domain IV (MutS_IV) (415-505)

• MutS domain II (MutS_II) (126-239)

• MutS domain III (MutS_III) (256-546)

• MutS domain V (MutS_V) (599-785)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
hexA	Streptococcus pneumoniae R6	73.474	100	0.735
mutS	Pseudomonas stutzeri strain ATCC 17587	36.133	100	0.369