Detailed information    

insolico Bioinformatically predicted

Overview

Name   letA   Type   Regulator
Locus tag   EW646_RS22505 Genome accession   NZ_CP035770
Coordinates   4533009..4533599 (-) Length   196 a.a.
NCBI ID   WP_000633668.1    Uniprot ID   P0AGA7
Organism   Escherichia coli O145 strain RM8988-C1     
Function   regulate competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 4528009..4538599
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  EW646_RS22490 (EW646_23055) uhpT 4528649..4530040 (-) 1392 WP_000879194.1 hexose-6-phosphate:phosphate antiporter -
  EW646_RS22495 (EW646_23060) uhpC 4530178..4531497 (-) 1320 WP_001301991.1 MFS transporter family glucose-6-phosphate receptor UhpC -
  EW646_RS22500 (EW646_23065) uhpB 4531507..4533009 (-) 1503 WP_001358729.1 signal transduction histidine-protein kinase/phosphatase UhpB -
  EW646_RS22505 (EW646_23070) letA 4533009..4533599 (-) 591 WP_000633668.1 transcriptional regulator UhpA Regulator
  EW646_RS22510 (EW646_23075) - 4533761..4534864 (-) 1104 WP_001419235.1 hypothetical protein -
  EW646_RS22515 (EW646_23080) - 4535472..4535953 (-) 482 Protein_4465 hypothetical protein -
  EW646_RS22520 (EW646_23085) - 4536101..4536523 (-) 423 WP_180192625.1 hypothetical protein -
  EW646_RS22525 - 4536595..4536753 (-) 159 WP_180192624.1 hypothetical protein -
  EW646_RS22530 (EW646_23090) ilvN 4537016..4537306 (-) 291 WP_001181706.1 acetolactate synthase small subunit -

Sequence

Protein


Download         Length: 196 a.a.        Molecular weight: 20889.30 Da        Isoelectric Point: 5.9982

>NTDB_id=304841 EW646_RS22505 WP_000633668.1 4533009..4533599(-) (letA) [Escherichia coli O145 strain RM8988-C1]
MITVALIDDHLIVRSGFAQLLGLEPDLQVVAEFGSGREALAGLPGRGVQVCICDISMPDISGLELLSQLPKGMATIMLSV
HDSPALVEQALNAGARGFLSKRCSPDELIAAVHTVATGGCYLTPDIAIKLASGRQDPLTKRERQVAEKLAQGMAVKEIAA
ELGLSPKTVHVHRANLMEKLGVSNDVELARRMFDGW

Nucleotide


Download         Length: 591 bp        

>NTDB_id=304841 EW646_RS22505 WP_000633668.1 4533009..4533599(-) (letA) [Escherichia coli O145 strain RM8988-C1]
ATGATCACCGTTGCCCTTATAGACGATCACCTCATCGTCCGCTCCGGCTTTGCGCAGTTGCTGGGGCTGGAACCTGATTT
GCAAGTAGTTGCCGAGTTTGGTTCGGGGCGCGAGGCGCTGGCGGGGCTGCCGGGGCGCGGTGTGCAGGTGTGTATTTGCG
ATATCTCCATGCCCGATATCTCCGGTCTGGAGCTGCTAAGCCAGCTGCCGAAAGGTATGGCGACAATTATGCTCTCCGTT
CATGACAGTCCGGCGCTGGTTGAGCAGGCGCTTAACGCGGGGGCGCGTGGCTTTCTCTCCAAGCGTTGTAGCCCTGACGA
ACTGATTGCTGCGGTGCATACGGTTGCCACAGGCGGCTGTTATCTGACGCCGGATATTGCCATTAAACTGGCATCCGGTC
GCCAGGACCCACTAACCAAACGTGAACGGCAGGTGGCGGAAAAACTGGCGCAAGGAATGGCGGTGAAAGAGATTGCCGCC
GAACTGGGCTTGTCACCGAAAACGGTACACGTCCATCGCGCCAATCTGATGGAAAAACTGGGCGTCAGTAACGACGTTGA
ACTGGCGCGCCGTATGTTTGATGGCTGGTGA

Domains

Predicted by InterProScan.

Bacterial regulatory proteins, luxR family (GerE)

(136-191)

Response regulator receiver domain (Response_reg)

(4-112)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB P0AGA7

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  letA Legionella pneumophila str. Paris

38.5

100

0.393
  letA Legionella pneumophila strain ERS1305867

38.5

100

0.393
  degU Bacillus subtilis subsp. subtilis str. 168

33.184

100

0.378