Detailed information NTG0296591

Bioinformatically predicted

Overview

• Name: uvrB
• Type: Machinery gene
• Locus tag: EQH29_RS05635
• Genome accession: NZ_CP035251
• Coordinates: 1135918..1137906 (-)
• Length: 662 a.a.
• NCBI ID: WP_000607035.1
• Uniprot ID: C1C7L7
• Organism: Streptococcus pneumoniae strain TVO_1901935
• Function: homologous recombination (predicted from homology) Homologous recombination

Genomic Context

Location: 1130918..1142906

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
EQH29_RS05595 (EQH29_05930)	coaB	1131217..1131906 (+)	690	WP_000699494.1	phosphopantothenate--cysteine ligase	-
EQH29_RS05600 (EQH29_05935)	coaC	1131918..1132469 (+)	552	WP_001284128.1	phosphopantothenoylcysteine decarboxylase	-
EQH29_RS05605 (EQH29_05940)	-	1132453..1133016 (+)	564	WP_000747408.1	ECF transporter S component	-
EQH29_RS05610 (EQH29_05945)	-	1133298..1133825 (+)	528	WP_001097402.1	ECF transporter S component	-
EQH29_RS05615 (EQH29_05950)	-	1133837..1134352 (+)	516	WP_000159176.1	transcription repressor NadR	-
EQH29_RS05620 (EQH29_05955)	-	1134349..1134816 (-)	468	WP_000091534.1	8-oxo-dGTP diphosphatase	-
EQH29_RS05625 (EQH29_05960)	-	1134890..1135378 (-)	489	WP_000216018.1	GNAT family N-acetyltransferase	-
EQH29_RS05630 (EQH29_05965)	-	1135344..1135907 (-)	564	WP_000639832.1	GNAT family N-acetyltransferase	-
EQH29_RS05635 (EQH29_05970)	uvrB	1135918..1137906 (-)	1989	WP_000607035.1	excinuclease ABC subunit UvrB	Machinery gene
EQH29_RS05640 (EQH29_05975)	-	1137983..1138936 (-)	954	WP_000792117.1	CPBP family intramembrane glutamic endopeptidase	-
EQH29_RS05645 (EQH29_05980)	-	1139106..1141271 (+)	2166	WP_000726272.1	ABC transporter substrate-binding protein/permease	-
EQH29_RS05650 (EQH29_05985)	-	1141271..1142011 (+)	741	WP_001096313.1	amino acid ABC transporter ATP-binding protein	-

Sequence

Protein

• Length: 662 a.a.
• Molecular weight: 75737.77 Da
• Isoelectric Point: 4.5848

>NTDB_id=296591 EQH29_RS05635 WP_000607035.1 1135918..1137906(-) (uvrB) [Streptococcus pneumoniae strain TVO_1901935]
MINHITDNQFKLVSKYQPSGDQPQAIEQLVDNIEGGEKAQILMGATGTGKTYTMSQVISKVNKPTLVIAHNKTLAGQLYG
EFKEFFPENAVEYFVSYYDYYQPEAYVPSSDTYIEKDSSVNDEIDKLRHSATSALLERNDVIVVASVSCIYGLGSPKEYA
DSVVSLRPGLEISRDKLLNDLVDIQFERNDIDFQRGRFRVRGDVVEIFPASRDEHAFRVEFFGDEIDRIREVEALTGQVL
GEVDHLAIFPATHFVTNDDHMEVAVAKIQAELEEQLAVFEKEGKLLEAQRLKQRTEYDIEMLREMGYTNGVENYSRHMDG
RSEGEPPYTLLDFFPDDFLIMIDESHMTMGQIKGMYNGDRSRKEMLVNYGFRLPSALDNRPLRREEFESHVHQIVYVSAT
PGDYENEQTETVIEQIIRPTGLLDPEVEVRPTMGQIDDLLGEINARVEKNERTFITTLTKKMAEDLTDYFKEMGIKVKYM
HSDIKTLERTEIIRDLRLGVFDVLVGINLLREGIDVPEVSLVAILDADKEGFLRNERGLIQTIGRAARNSEGHVIMYADT
VTQSMQRAIDETARRRKIQMAYNEEHGIVPQTIKKEIRDLIAVTKAVAKEEDKEVDINSLNKQERKELVKKLEKQMQEAV
EVLDFELAAQIRDMMLEVKALD

Nucleotide

• Length: 1989 bp

>NTDB_id=296591 EQH29_RS05635 WP_000607035.1 1135918..1137906(-) (uvrB) [Streptococcus pneumoniae strain TVO_1901935]
ATGATCAATCACATTACAGATAATCAATTTAAACTAGTATCAAAATATCAACCATCAGGAGATCAACCCCAAGCTATCGA
GCAGTTGGTGGATAACATTGAGGGGGGAGAAAAAGCTCAGATTCTGATGGGGGCGACTGGAACAGGGAAGACCTATACTA
TGAGTCAGGTCATTTCTAAAGTCAATAAACCAACTCTGGTTATTGCCCACAATAAAACTCTGGCTGGTCAGCTCTATGGG
GAGTTTAAGGAATTTTTCCCTGAAAATGCAGTTGAGTATTTCGTATCCTACTATGATTATTACCAGCCAGAGGCCTATGT
CCCTTCTAGCGATACCTATATTGAGAAGGATAGTTCTGTCAATGACGAGATTGACAAGCTTCGCCACTCAGCTACCTCAG
CCCTTTTGGAGCGTAATGATGTTATTGTCGTGGCCTCAGTCTCTTGTATCTATGGTTTGGGTTCGCCCAAGGAATACGCT
GATAGTGTCGTTAGTCTCCGTCCTGGTCTAGAGATTTCTCGTGATAAACTCTTGAATGACTTGGTCGATATTCAGTTTGA
ACGTAATGATATTGATTTCCAACGCGGAAGATTTCGCGTTCGTGGGGATGTGGTAGAGATTTTCCCAGCTTCCCGAGATG
AACATGCCTTTCGAGTAGAATTTTTTGGAGACGAAATTGACCGTATCCGTGAGGTTGAGGCTCTGACAGGTCAGGTATTG
GGAGAGGTGGATCATTTGGCGATTTTCCCAGCTACTCACTTTGTGACCAATGACGACCATATGGAAGTTGCCGTTGCCAA
GATTCAAGCAGAATTAGAAGAGCAGTTAGCTGTCTTTGAGAAGGAAGGTAAATTGCTTGAAGCCCAGCGCTTGAAACAAC
GGACAGAGTACGATATCGAAATGCTGCGCGAGATGGGCTATACAAATGGGGTTGAAAATTATTCTCGCCACATGGATGGA
CGGAGCGAAGGAGAGCCTCCTTATACGCTTCTCGACTTTTTCCCAGATGATTTTTTGATTATGATTGACGAGAGTCATAT
GACTATGGGACAAATAAAAGGCATGTACAATGGAGACCGTTCGCGTAAGGAAATGCTAGTAAATTATGGTTTCCGTTTAC
CGTCTGCCTTGGACAATCGTCCTCTCCGTCGTGAGGAGTTTGAAAGCCATGTGCATCAGATTGTTTACGTATCAGCGACA
CCTGGTGACTATGAAAATGAACAGACTGAGACGGTGATTGAGCAAATCATTCGACCGACAGGGCTTTTGGATCCTGAGGT
GGAAGTCCGTCCGACTATGGGACAGATTGATGATCTCTTAGGTGAAATCAATGCCCGTGTTGAAAAGAATGAACGAACCT
TTATCACCACCTTGACCAAGAAAATGGCAGAGGACTTGACCGACTATTTCAAGGAAATGGGCATCAAGGTCAAGTACATG
CACTCGGATATCAAGACCTTGGAACGGACGGAGATTATCCGTGATCTCCGCTTGGGTGTCTTTGATGTCTTGGTTGGAAT
CAATCTCCTTCGTGAAGGGATTGACGTTCCTGAGGTTAGCTTGGTTGCCATTCTCGATGCTGACAAGGAAGGTTTCCTTC
GTAACGAGCGTGGACTCATCCAGACCATTGGGCGTGCCGCCCGTAACAGTGAAGGTCATGTCATCATGTATGCAGATACG
GTTACCCAGTCTATGCAACGTGCTATCGATGAAACTGCCCGCCGTCGGAAAATTCAGATGGCCTATAATGAAGAGCATGG
TATCGTACCACAGACAATCAAGAAAGAAATCCGTGACCTGATTGCCGTGACCAAGGCAGTTGCTAAGGAAGAGGACAAGG
AAGTCGACATCAATAGCCTCAACAAACAAGAGCGCAAAGAACTCGTCAAGAAACTAGAAAAACAAATGCAAGAAGCCGTC
GAAGTGCTTGACTTTGAACTGGCGGCTCAGATCCGTGATATGATGTTGGAAGTCAAGGCCTTGGATTAG

Domains

Predicted by InterProScan.

• UvrB/uvrC motif (UVR) (626-660)

• Type III restriction enzyme, res subunit (ResIII) (17-143)

• Ultra-violet resistance protein B (UvrB) (556-598)

• Helicase conserved C-terminal domain (Helicase_C) (443-549)

• UvrB interaction domain (UvrB_inter) (164-254)

3D structure

• AlphaFold DB: C1C7L7

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
uvrB	Streptococcus pneumoniae R6	99.849	100	0.998
uvrB	Streptococcus pneumoniae D39	99.849	100	0.998
uvrB	Streptococcus pneumoniae TIGR4	99.698	100	0.997