Detailed information NTG0295280

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: C7M54_RS10960
• Genome accession: NZ_CP029685
• Coordinates: 2092325..2093368 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain CMRSA-3
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2087325..2098368

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
C7M54_RS10930 (C7M54_10930)	-	2087743..2088999 (-)	1257	WP_001795438.1	aminopeptidase	-
C7M54_RS10935 (C7M54_10935)	-	2089002..2089202 (-)	201	WP_000180461.1	DUF1128 family protein	-
C7M54_RS10940 (C7M54_10940)	-	2089349..2089813 (+)	465	WP_000228665.1	low molecular weight protein-tyrosine-phosphatase	-
C7M54_RS10945 (C7M54_10945)	-	2089820..2090095 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
C7M54_RS10950 (C7M54_10950)	-	2090373..2091590 (+)	1218	WP_000037075.1	YihY/virulence factor BrkB family protein	-
C7M54_RS10955 (C7M54_10955)	vraR	2091706..2092335 (-)	630	WP_000153530.1	two-component system response regulator VraR	Regulator
C7M54_RS10960 (C7M54_10960)	vraS	2092325..2093368 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
C7M54_RS10965 (C7M54_10965)	liaF	2093365..2094066 (-)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
C7M54_RS10970 (C7M54_10970)	-	2094081..2094467 (-)	387	WP_001110179.1	hypothetical protein	-
C7M54_RS10975 (C7M54_10975)	map	2094684..2095442 (-)	759	WP_000636143.1	type I methionyl aminopeptidase	-
C7M54_RS10985 (C7M54_10985)	-	2096029..2097015 (+)	987	WP_000999713.1	aromatic acid exporter family protein	-
C7M54_RS10995 (C7M54_10995)	-	2097446..2097859 (-)	414	WP_001549145.1	hypothetical protein	-
C7M54_RS11000 (C7M54_11000)	-	2097888..2097998 (-)	111	WP_001790257.1	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=295280 C7M54_RS10960 WP_001017131.1 2092325..2093368(-) (vraS) [Staphylococcus aureus strain CMRSA-3]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=295280 C7M54_RS10960 WP_001017131.1 2092325..2093368(-) (vraS) [Staphylococcus aureus strain CMRSA-3]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTTTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
TATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGATAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1