Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaH   Type   Regulator
Locus tag   DK181_RS04330 Genome accession   NZ_CP029490
Coordinates   894093..895478 (+) Length   461 a.a.
NCBI ID   WP_002961522.1    Uniprot ID   U2KIP2
Organism   Streptococcus sobrinus strain SL1     
Function   Required for optimal comC expression (predicted from homology)   
Competence regulation

Genomic Context

Location: 889093..900478
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  DK181_RS04315 (DK182_04315) phoU 889861..890514 (+) 654 WP_002961527.1 phosphate signaling complex protein PhoU -
  DK181_RS04320 (DK182_04320) - 890621..893164 (+) 2544 WP_002961526.1 M1 family metallopeptidase -
  DK181_RS04325 (DK182_04325) ciaR 893429..894103 (+) 675 WP_002961524.1 response regulator transcription factor Regulator
  DK181_RS04330 (DK182_04330) ciaH 894093..895478 (+) 1386 WP_002961522.1 sensor histidine kinase Regulator
  DK181_RS04335 (DK182_04335) rpsT 895593..895841 (-) 249 WP_019772096.1 30S ribosomal protein S20 -
  DK181_RS04340 (DK182_04340) coaA 895894..896814 (-) 921 WP_002961520.1 type I pantothenate kinase -
  DK181_RS04345 (DK182_04345) - 896879..897469 (+) 591 WP_019777495.1 class I SAM-dependent methyltransferase -
  DK181_RS04350 (DK182_04350) - 897466..898743 (+) 1278 WP_002963359.1 pyrimidine-nucleoside phosphorylase -
  DK181_RS04355 (DK182_04355) deoC 898751..899413 (+) 663 WP_002963360.1 deoxyribose-phosphate aldolase -
  DK181_RS04360 (DK182_04360) - 899400..899819 (+) 420 WP_002963361.1 cytidine deaminase -

Sequence

Protein


Download         Length: 461 a.a.        Molecular weight: 51957.18 Da        Isoelectric Point: 6.1942

>NTDB_id=293159 DK181_RS04330 WP_002961522.1 894093..895478(+) (ciaH) [Streptococcus sobrinus strain SL1]
MLNKLKKRIFSEGFSTFLHFLSVFTVIFLVMTILILQIMRIGIYSSVDDNLNKAVDSVDSYIYMNMYRASLYSAFGGKNN
SDLSVLTDGDEFLGNGTTLPGNANSTVNQSPNKSHVELNATIETIIYDKNGKVLNSSEIFSGLNKLKIDKSELGEVNEVS
VNGSFREKEHYRYKTVSVSDKQFPKVAYVTIAISVNQLDSANSRYQIIIITVMIIFWLLSVFASVYLANWSRKPILESYE
KQKNFVEDASHELRTPLTVLQNRLESLFRKPDETILDNYETVASSLEEVRNMRILTTNLLNLARRDDKLNPEIEEIEPNF
FDNIFENYSLIAEESGKVLSCSNQLRTSIKSDKTLIKQVMTILFDNAVKYTGDDGAIRITVSNSDRKLVITVADNGSGIS
EEDKSKIFDRFYRIDKARTRQTGGFGLGLSLAKQIVEALKGTIAVRDNTPTGTVFEIKLNT

Nucleotide


Download         Length: 1386 bp        

>NTDB_id=293159 DK181_RS04330 WP_002961522.1 894093..895478(+) (ciaH) [Streptococcus sobrinus strain SL1]
ATGTTAAATAAGTTAAAGAAGAGGATCTTTTCTGAAGGGTTCTCGACTTTTCTTCACTTCCTATCCGTTTTCACTGTTAT
TTTCCTAGTGATGACCATTCTGATTTTGCAAATTATGCGGATTGGAATCTACTCATCGGTTGACGATAATCTCAACAAGG
CTGTAGATAGTGTTGATTCTTATATCTACATGAATATGTACAGAGCTAGCCTTTATTCAGCCTTTGGCGGAAAAAATAAT
TCTGATTTATCTGTTTTAACCGATGGTGATGAATTTTTAGGAAACGGGACAACTTTGCCTGGTAATGCTAATTCAACGGT
GAATCAAAGTCCAAATAAATCTCATGTTGAATTGAATGCAACTATTGAAACCATTATATATGACAAGAATGGTAAGGTAC
TTAATAGCTCGGAAATATTTTCTGGTCTTAATAAGCTGAAAATTGATAAGAGTGAGCTAGGCGAGGTTAACGAGGTTAGT
GTTAACGGTAGCTTTCGTGAAAAGGAGCATTATCGGTATAAGACTGTCTCGGTGTCGGACAAGCAATTCCCAAAGGTTGC
TTATGTGACGATTGCTATTAGTGTTAACCAATTAGATAGTGCCAATTCTCGCTATCAAATTATTATCATTACGGTTATGA
TTATTTTCTGGCTCTTATCTGTCTTTGCCAGTGTTTATCTGGCTAATTGGTCGCGTAAGCCAATTCTTGAAAGTTATGAG
AAACAGAAGAATTTTGTAGAAGATGCCAGTCATGAGTTGAGGACGCCTCTAACGGTTCTCCAAAATCGTTTGGAAAGTCT
TTTTCGTAAGCCTGATGAGACCATTTTGGATAATTACGAGACTGTCGCCTCTAGTTTGGAAGAAGTTCGGAATATGCGGA
TTTTAACCACGAATCTTTTGAATCTGGCTAGACGTGATGACAAACTTAATCCAGAAATTGAAGAAATTGAACCTAATTTC
TTCGACAATATTTTTGAGAATTATAGTTTAATTGCTGAGGAAAGTGGCAAAGTCCTATCTTGTAGCAACCAATTAAGGAC
CTCAATCAAGTCGGATAAGACCTTGATTAAACAAGTTATGACTATCCTTTTTGATAATGCTGTTAAGTATACTGGAGATG
ACGGTGCTATAAGGATTACTGTTTCCAATAGTGATAGAAAGCTGGTTATTACTGTTGCGGATAATGGTTCGGGAATCAGT
GAAGAAGACAAATCGAAAATTTTCGATCGATTTTATCGGATTGACAAGGCGCGAACCCGGCAGACTGGTGGTTTTGGTCT
AGGACTATCCTTAGCTAAGCAGATTGTTGAAGCTTTGAAGGGGACTATTGCTGTTCGAGATAACACACCCACGGGTACTG
TTTTTGAAATTAAATTAAATACTTAA

Domains

Predicted by InterproScan.

His Kinase A (phospho-acceptor) domain (HisKA)

(242-306)

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c)

(352-459)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB U2KIP2

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaH Streptococcus mutans UA159

54.031

99.566

0.538
  ciaH Streptococcus pneumoniae Rx1

48.06

100

0.484
  ciaH Streptococcus pneumoniae D39

48.06

100

0.484
  ciaH Streptococcus pneumoniae R6

48.06

100

0.484
  ciaH Streptococcus pneumoniae TIGR4

48.06

100

0.484

Multiple sequence alignment