Detailed information NTG0290892

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: DD555_RS10735
• Genome accession: NZ_CP029166
• Coordinates: 2064323..2065366 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain SVH7513
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2059323..2070366

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
DD555_RS10705 (DD555_10705)	-	2059741..2060997 (-)	1257	WP_001797521.1	aminopeptidase	-
DD555_RS10710 (DD555_10710)	-	2061000..2061200 (-)	201	WP_000180461.1	DUF1128 family protein	-
DD555_RS10715 (DD555_10715)	-	2061347..2061811 (+)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
DD555_RS10720 (DD555_10720)	-	2061818..2062093 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
DD555_RS10725 (DD555_10725)	-	2062371..2063588 (+)	1218	WP_000037075.1	YihY/virulence factor BrkB family protein	-
DD555_RS10730 (DD555_10730)	vraR	2063704..2064333 (-)	630	WP_000153530.1	two-component system response regulator VraR	Regulator
DD555_RS10735 (DD555_10735)	vraS	2064323..2065366 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
DD555_RS10740 (DD555_10740)	liaF	2065363..2066064 (-)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
DD555_RS10745 (DD555_10745)	-	2066079..2066465 (-)	387	WP_001110181.1	hypothetical protein	-
DD555_RS10750 (DD555_10750)	map	2066682..2067440 (-)	759	WP_000636142.1	type I methionyl aminopeptidase	-
DD555_RS10760 (DD555_10760)	-	2068027..2069013 (+)	987	WP_000999713.1	FUSC family protein	-
DD555_RS10770 (DD555_10770)	-	2069503..2069916 (-)	414	WP_001549145.1	hypothetical protein	-
DD555_RS10775 (DD555_10775)	-	2069945..2070055 (-)	111	WP_001790257.1	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=290892 DD555_RS10735 WP_001017131.1 2064323..2065366(-) (vraS) [Staphylococcus aureus strain SVH7513]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=290892 DD555_RS10735 WP_001017131.1 2064323..2065366(-) (vraS) [Staphylococcus aureus strain SVH7513]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTTTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
TATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGATAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1